28 completed, 4 active not recruiting, 4 terminated, 3 withdrawn. 41 Phase 2, 9 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 41 | Completed 28, Active not recruiting 4, Terminated 4, Withdrawn 3, Unknown 2 |
| Phase 1 | 9 | Completed 4, Withdrawn 2, Active not recruiting 1, Terminated 1, Unknown 1 |
Follow Pentostatin: new trials by email Literature Review of Pentostatin trials Research Report on Pentostatin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation e-ATG, Immunosuppression Only Conditioning, Reduced Intensity Conditioning - Lymphoproliferative Disorders, Autoimmune Lymphoproliferative | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 71 | 2018-09-04 | 2026-03-17 |
| Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease haploidentical stem cell transplant, Sirolimus, Alemtuzumab - Sickle Cell Disease | Phase 1 / Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 57 | 2017-04-06 | 2026-04-23 |
| Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure Alemtuzumab, Sirolimus, Cyclophosphamide - Sickle Cell Disease, Thalassemia | Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 56 | 2014-04-21 | 2026-08-18 |
| Trial of Pentostatin Plus Cyclophosphamide With Ofatumumab (PCO) in Older Patients With Chronic Lymphocytic Leukemia Pentostatin, Cyclophosphamide, Ofatumumab - Chronic Lymphocytic Leukemia | Phase 2 | Completed | Niguarda Hospital | 47 | 2011-09-01 | 2016-12-28 |
| SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma Pentostatin, Cyclophosphamide, SS1(dsFv)PE38 - lot 073I0809 - Mesothelioma, Adenocarcinoma of Lung | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 55 | 2011-05-11 | 2019-06-06 |
| Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia Pentostatin, Rituximab, Bendamustine - Hairy Cell Leukemia | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 69 | 2010-07-01 | 2026-10-15 |
| Velcade, Nipent, Rituxan (VNR) in Subjects With Relapsed Follicular, Marginal Zone, and Mantle Cell Lymphoma MTD of Velcade, Nipent and Rituxan established in Part 1 - Follicular Lymphoma, Marginal Zone Lymphoma | Phase 1 / Phase 2 | Withdrawn | Louisiana State University Health Sciences Center Shreveport | 2010-05-01 | 2020-09-01 | |
| Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Cyclophosphamide, Laboratory Biomarker Analysis, Ofatumumab - Chronic Lymphocytic Leukemia, Stage 0 Chronic Lymphocytic Leukemia | Phase 2 | Completed | Mayo Clinic | 82 | 2010-03-01 | 2018-09-18 |
| Neoadjuvant Combination Chemotherapy of DCS and DCF in Patients With Locally Advanced Gastric Adenocarcinoma DCS (docetaxel with cisplatin with TS-1), DCF (docetaxel with cisplatin with 5-FU) - Gastric Cancer | Phase 2 | Completed | Yonsei University | 6 | 2009-09-01 | 2024-12-27 |
| Pentostatin, Cyclophosphamide Plus Rituximab (PCR) for the Therapy of Poor-Prognosis Chronic Graft-Versus-Host Disease Pentostatin; Cyclophosphamide; Rituximab - Active Chronic Graft Versus Host Disease | Phase 2 | Withdrawn | University of Rochester | 2009-08-01 | 2013-10-16 | |
| Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma bevacizumab, pegfilgrastim, rituximab - Leukemia, Lymphoma | Phase 2 | Completed | Mayo Clinic | 68 | 2009-02-01 | 2017-06-15 |
| Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer cyclosporine, mycophenolate mofetil, pentostatin - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 / Phase 2 | Withdrawn | University of Nebraska | 2008-09-01 | 2023-08-14 | |
| Pentostatin, Alemtuzumab, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma alemtuzumab, rituximab, pentostatin - Leukemia, Lymphoma | Phase 2 | Completed | Mayo Clinic | 41 | 2008-07-01 | 2014-07-01 |
| Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia Cordycepin plus Pentostatin - Refractory TdT-Positive Leukemia | Phase 1 / Phase 2 | Unknown | OncoVista, Inc. | 44 | 2008-06-01 | 2009-01-09 |
| Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney Cancer Pentostatin, Sirolimus, Cyclophosphamide - Renal Cell Carcinoma, Graft-Versus-Host Disease | Phase 2 | Completed | National Cancer Institute (NCI) | 25 | 2008-03-01 | 2017-09-29 |
| Rituximab, Pentostatin, Cyclophosphamide, and Lenalidomide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Rituximab, Cyclophosphamide, Lenalidomide - Leukemia, Lymphoma | Phase 2 | Completed | Mayo Clinic | 45 | 2008-02-01 | 2020-01-27 |
| Phase II Trial of Pentostatin and Targeted Busulfan Pentostatin, Busulfan, Rituximab - Hematologic Malignancies | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 42 | 2007-07-01 | 2014-06-05 |
| Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic Syndromes Cyclosporine, Methotrexate, Photopheresis - Leukemia, Myelodysplastic Syndromes | Phase 2 | Completed | Eastern Cooperative Oncology Group | 17 | 2006-10-24 | 2023-06-28 |
| A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies extracorporeal photopheresis, Pentostatin, Total Body Irradiation - Hematologic Malignancies | Phase 2 | Completed | Yale University | 14 | 2006-07-01 | 2017-01-18 |
| Pentostatin and Alemtuzumab as a Preparative Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation Pentostatin, Alemtuzumab, Allogeneic hematopoietic stem cell transplantation - Leukemia, Lymphoma | Phase 2 | Terminated | University of Arizona | 14 | 2006-01-23 | 2017-03-31 |
Showing 20 of 41. Sign in to see all of them.
Leukemia, Lymphocytic, Chronic, B-Cell (19) · Lymphoma (16) · Leukemia (15) · Graft vs Host Disease (10) · Lymphoma, B-Cell, Marginal Zone (7) · Lymphoma, Follicular (7) · Hodgkin Disease (5) · Lymphoma, Non-Hodgkin (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Leukemia, Myeloid, Acute (4) · Lymphoma, Mantle-Cell (4) · Myelodysplastic Syndromes (4) · Carcinoma, Renal Cell (3) · Hematologic Neoplasms (3) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (3)
M.D. Anderson Cancer Center (4) · Mayo Clinic (4) · National Cancer Institute (NCI) (4) · Eastern Cooperative Oncology Group (3) · Memorial Sloan Kettering Cancer Center (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Ohio State University Comprehensive Cancer Center (2) · University of Nebraska (2) · Alliance for Clinical Trials in Oncology (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Astex Pharmaceuticals, Inc. (1) · Fred Hutchinson Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Heidelberg University (1) · Hoag Memorial Hospital Presbyterian (1)
United States (37) · Italy (2) · South Korea (1)
Renier Brentjens, MD, PhD (2) · Tait D. Shanafelt, MD (2) · Agostino Cortelezzi, MD (1) · Alessandro Rambaldi, MD (1) · Andrew D. Zelenetz, MD, PhD (1) · Andrew M Yeager, MD (1) · Anthony D Ho, Ph.D., Prof. (1) · Antonino Mazzone, MD (1) · Armando Santoro, MD (1) · Brenda Sandmaier (1) · Clive S. Zent, MD (1) · Courtney F Joseph, M.D. (1) · Craig Hofmeister, MD (1) · Daneil J DeAngelo, MD, PhD. (1) · Daniel H Fowler, M.D. (1)
PMID 36240296, PMID 42133908, PMID 12663715, PMID 16520464, PMID 17514743, PMID 19443659, PMID 19654407, PMID 19745067, PMID 19925875, PMID 20187101, PMID 20541024, PMID 22383800, PMID 23588536, PMID 24431228, PMID 24723493, PMID 26071480, PMID 26294723, PMID 27570087, PMID 33225826, PMID 40010689, PMID 41060318, PMID 41871072
P30CA015083 (3), U10CA021115 (2), P01CA078902 (1), P30CA008748 (1), P30CA015704 (1), P30CA036727 (1), R21CA106177 (1), U01HL069294 (1), U10CA031946 (1)