5 completed, 2 active not recruiting, 2 terminated, 2 withdrawn. 13 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 5, Active not recruiting 2, Terminated 2, Withdrawn 2, Recruiting 1, Unknown 1 |
| Phase 2 | 9 | Completed 4, Withdrawn 2, Active not recruiting 1, Terminated 1, Unknown 1 |
Follow Pentostatin: new trials by email Literature Review of Pentostatin trials Research Report on Pentostatin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia Anti-Thymocyte Globulin, Biospecimen Collection, Bone Marrow Aspirate - Recurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2024-11-15 | 2026-01-05 |
| A Blood Stem Cell Transplant for Sickle Cell Disease Cyclophosphamide, Pentostatin, Rabbit anti-thymocyte globulin - Sickle Cell Disease, Sickle Cell Disorder | Phase 1 | Active not recruiting | City of Hope Medical Center | 3 | 2019-01-04 | 2026-03-05 |
| Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease haploidentical stem cell transplant, Sirolimus, Alemtuzumab - Sickle Cell Disease | Phase 1 / Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 57 | 2017-04-06 | 2026-04-23 |
| Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma Bendamustine, Pentostatin, Ofatumumab - Chronic Lymphocytic Leukemia, B-Cell Non-Hodgkin's Lymphoma | Phase 1 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 10 | 2011-05-25 | 2025-04-29 |
| SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma Pentostatin, Cyclophosphamide, SS1(dsFv)PE38 - lot 073I0809 - Mesothelioma, Adenocarcinoma of Lung | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 55 | 2011-05-11 | 2019-06-06 |
| Velcade, Nipent, Rituxan (VNR) in Subjects With Relapsed Follicular, Marginal Zone, and Mantle Cell Lymphoma MTD of Velcade, Nipent and Rituxan established in Part 1 - Follicular Lymphoma, Marginal Zone Lymphoma | Phase 1 / Phase 2 | Withdrawn | Louisiana State University Health Sciences Center Shreveport | 2010-05-01 | 2020-09-01 | |
| Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer cyclosporine, mycophenolate mofetil, pentostatin - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 / Phase 2 | Withdrawn | University of Nebraska | 2008-09-01 | 2023-08-14 | |
| Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia Cordycepin plus Pentostatin - Refractory TdT-Positive Leukemia | Phase 1 / Phase 2 | Unknown | OncoVista, Inc. | 44 | 2008-06-01 | 2009-01-09 |
| Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer filgrastim, pegfilgrastim, rituximab - Leukemia, Lymphoma | Phase 1 / Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 50 | 2005-07-01 | 2016-05-12 |
| Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD pentostatin for injection - Acute Graft Versus Host Disease | Phase 1 / Phase 2 | Terminated | Astex Pharmaceuticals, Inc. | 36 | 2002-01-30 | 2024-08-02 |
| Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT Pentostatin, Tacrolimus, Methotrexate - Leukemia, Lymphoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 150 | 2000-09-01 | 2015-04-28 |
| Pentostatin Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Kidney Cancer filgrastim, cyclosporine, pentostatin - Kidney Cancer | Phase 1 / Phase 2 | Completed | Jonsson Comprehensive Cancer Center | 4 | 2000-09-01 | 2013-01-08 |
| Chemotherapy With Cordycepin Plus Pentostatin in Treating Patients With Refractory Acute Lymphocytic or Chronic Myelogenous Leukemia Cordycepin, Deoxycoformycin - Leukemia | Phase 1 | Completed | Boston Medical Center | 14 | 1997-12-01 | 2012-06-13 |
Leukemia (5) · Lymphoma (5) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Lymphoma, B-Cell, Marginal Zone (3) · Lymphoma, Follicular (3) · Lymphoma, Mantle-Cell (3) · Anemia, Aplastic (2) · Anemia, Sickle Cell (2) · Blast Crisis (2) · Graft vs Host Disease (2) · Lymphoma, Non-Hodgkin (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Adenocarcinoma of Lung (1) · Carcinoma, Renal Cell (1) · Congenital Abnormalities (1)
City of Hope Medical Center (2) · Astex Pharmaceuticals, Inc. (1) · Boston Medical Center (1) · Jonsson Comprehensive Cancer Center (1) · Louisiana State University Health Sciences Center Shreveport (1) · M.D. Anderson Cancer Center (1) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · OncoVista, Inc. (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Nebraska (1)
United States (12)
Andrew D. Zelenetz, MD, PhD (1) · Courtney F Joseph, M.D. (1) · Daneil J DeAngelo, MD, PhD. (1) · Francesco Turturro, MD (1) · Gary J. Schiller, MD (1) · Jo Fili, MD (1) · Joseph Rosenthal, MD (1) · Marcos de Lima, MD (1) · Raffit Hassan, M.D. (1) · Renier Brentjens, MD, PhD (1) · Robert Bociek, MD (1) · Ryotaro Nakamura (1) · Swaminathan Padmanabhan, MD (1) · Timothy J. Ernst, MD (1)
PMID 19654407, PMID 33225826, PMID 36240296, PMID 41871072, PMID 42133908
P30CA033572 (1), P30CA036727 (1)