13 completed, 7 terminated, 1 unknown, 1 withdrawn. 13 Phase 2, 6 Phase 3, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 10, Terminated 2, Withdrawn 1 |
| Phase 3 | 6 | Terminated 5, Unknown 1 |
| Phase 1 | 5 | Completed 5 |
Follow paclitaxel poliglumex: new trials by email Literature Review of paclitaxel poliglumex trials Research Report on paclitaxel poliglumex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation PPX (CT2103), Temozolomide - Glioblastoma Multiforme | Phase 2 | Completed | Brown University | 63 | 2011-09-01 | 2020-02-17 |
| Neoadjuvant Doxorubicin, Polyglutamate Paclitaxel, Capecitabine and Metronomic Chemotherapy in Breast Cancer doxorubicin, paclitaxel poliglumex, capecitabine, cyclophosphamide, methotrexate - Breast Cancer | Phase 2 | Withdrawn | University of Southern California | 2009-02-01 | 2017-05-02 | |
| A Phase I/II Study of Radiation Therapy, Paclitaxel Poliglumex and Cetuximab in Advanced Head and Neck Cancer paclitaxel poliglumex, cetuximab, radiation therapy (IMRT or 3D-CRT) - Carcinoma, Squamous Cell | Phase 1 / Phase 2 | Completed | State University of New York - Upstate Medical University | 53 | 2008-03-01 | 2021-11-08 |
| A Pilot Study of PPX in Women With Metastatic Colorectal Cancer Paclitaxel Poliglumex - Advanced Colorectal Cancer | Phase 1 | Completed | University of Southern California | 15 | 2008-01-01 | 2014-02-06 |
| Carboplatin With Either Paclitaxel Poliglumex or Paclitaxel in Treating Women With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer carboplatin, paclitaxel, paclitaxel poliglumex - Lung Cancer | Phase 3 | Terminated | CTI BioPharma | 450 | 2007-08-01 | 2020-10-05 |
| Neoadjuvant Paclitaxel Poliglumex, Cisplatin and Radiation for Esophageal Cancer: A Phase II Trial (CTI#X64001) PPX with cisplatin and radiation - Esophageal Cancer | Phase 2 | Completed | Brown University | 40 | 2007-08-01 | 2020-02-17 |
| Paclitaxel Poliglumex and Estradiol in Treating Patients With Stage IV Prostate Cancer transdermal estradiol, paclitaxel poliglumex - Prostate Cancer | Phase 2 | Terminated | OHSU Knight Cancer Institute | 21 | 2007-02-01 | 2017-04-28 |
| Phase II Study of Combination of Paclitaxel Poliglumex and Alimta for Advanced Non-small Cell Lung Cancer (NSCLC) paclitaxel poliglumex, pemetrexed - Advanced Non-small Cell Lung Cancer | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 14 | 2006-10-01 | 2014-01-09 |
| A Phase II Study of Radiation Therapy, Paclitaxel Poliglumex, and Carboplatin in Stage III Non-Small Cell Lung Cancer Paclitaxel poliglumex, Carboplatin, External beam radiation therapy - Carcinoma, Non-Small-Cell Lung | Phase 2 | Terminated | Washington University School of Medicine | 10 | 2006-04-01 | 2016-12-12 |
| Paclitaxel Poliglumex and Capecitabine in Treating Patients With Metastatic Breast Cancer capecitabine, paclitaxel poliglumex - Breast Cancer | Phase 2 | Completed | Alliance for Clinical Trials in Oncology | 48 | 2006-02-01 | 2016-12-06 |
| CT-2103 in Combination With Gemcitabine in Metastatic Breast Cancer CT-2103, Gemcitabine - Metastatic Breast Cancer, Breast Cancer | Phase 1 | Completed | M.D. Anderson Cancer Center | 13 | 2005-12-01 | 2013-02-13 |
| A Survival Study for Women With Advanced Lung Cancer Who Have Not Previously Received Chemotherapy. paclitaxel, paclitaxel poliglumex - NSCLC | Phase 3 | Terminated | CTI BioPharma | 600 | 2005-12-01 | 2020-11-24 |
| Paclitaxel, Polyglutamate Paclitaxel, or Observation in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Peritoneal Cancer, or Fallopian Tube Cancer Clinical Observation, Laboratory Biomarker Analysis, Paclitaxel - Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma | Phase 3 | Unknown | GOG Foundation | 1157 | 2005-03-21 | 2021-09-30 |
| Efficacy and Safety Study of Xyotax to Treat Prostate Cancer Paclitaxel polyglumex (Xyotax) - Prostatic Neoplasms | Phase 2 | Completed | The Methodist Hospital Research Institute | 29 | 2005-03-01 | 2016-03-17 |
| Study of Xyotax (CT-2103) in Patients With Metastatic Breast Cancer CT-2103 (Xyotax) - Breast Cancer, Metastatic Breast Cancer | Phase 2 | Completed | Dana-Farber Cancer Institute | 45 | 2004-10-01 | 2007-12-21 |
| Polyglutamate Paclitaxel and Carboplatin in Treating Patients With Ovarian Epithelial, Peritoneal, or Fallopian Tube Cancer Carboplatin, Paclitaxel Poliglumex, Pharmacological Study - Fallopian Tube Carcinoma, Malignant Ovarian Mixed Epithelial Tumor | Phase 1 | Completed | Gynecologic Oncology Group | 32 | 2003-04-01 | 2015-05-08 |
| Phase II CT-2103/Carboplatin in Ovarian Cancer CT-2103 (poly(L)glutamate-paclitaxel), carboplatin - Ovarian Neoplasm | Phase 2 | Completed | CTI BioPharma | 82 | 2003-02-01 | 2008-09-22 |
| Polyglutamate Paclitaxel Plus Carboplatin Compared With Paclitaxel Plus Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer carboplatin, paclitaxel, paclitaxel poliglumex - Lung Cancer | Phase 3 | Terminated | CTI BioPharma | 2003-01-01 | 2020-10-05 | |
| Polyglutamate Paclitaxel Compared With Gemcitabine or Vinorelbine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer gemcitabine hydrochloride, paclitaxel poliglumex, vinorelbine tartrate - Lung Cancer | Phase 3 | Terminated | CTI BioPharma | 2003-01-01 | 2020-10-05 | |
| Polyglutamate Paclitaxel Compared With Docetaxel in Treating Patients With Progressive Non-Small Cell Lung Cancer docetaxel, paclitaxel poliglumex - Lung Cancer | Phase 3 | Terminated | CTI BioPharma | 350 | 2003-01-01 | 2020-10-05 |
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Carcinoma, Non-Small-Cell Lung (6) · Breast Neoplasms (4) · Lung Neoplasms (4) · Ovarian Neoplasms (4) · Fallopian Tube Neoplasms (3) · Brenner Tumor (2) · Prostatic Neoplasms (2) · Brain Neoplasms (1) · Breast Neoplasms, Male (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Squamous Cell (1) · Esophageal Neoplasms (1) · Glioblastoma (1) · Head and Neck Neoplasms (1)
CTI BioPharma (6) · Brown University (2) · Gynecologic Oncology Group (2) · University of Southern California (2) · Alliance for Clinical Trials in Oncology (1) · Dana-Farber Cancer Institute (1) · Dartmouth-Hitchcock Medical Center (1) · GOG Foundation (1) · M.D. Anderson Cancer Center (1) · Memorial Sloan Kettering Cancer Center (1) · OHSU Knight Cancer Institute (1) · State University of New York - Upstate Medical University (1) · The Methodist Hospital Research Institute (1) · Washington University School of Medicine (1)
United States (21) · Canada (2) · Argentina (1) · Bulgaria (1) · Hungary (1) · Mexico (1) · Poland (1) · Romania (1) · Russia (1) · Ukraine (1) · United Kingdom (1)
Howard Safran, MD (2) · Agustin Garcia, MD (1) · Brenda Garrison (1) · Edith A. Perez, MD (1) · Fred B. Oldham, MD (1) · James R Rigas, MD (1) · Larry J Copeland (1) · Lawrence N. Shulman, MD (1) · Marjorie Green, MD (1) · Mark Morgan (1) · Meghann Smith (1) · Melinda Bomar (1) · Paul Sabbatini (1) · Paul Sabbatini, MD (1) · Ramaswamy Govindan, M.D. (1)
PMID 18520802, PMID 18594318, PMID 23388562, PMID 35759733
U10CA027469 (3), U10CA180868 (1)