27 completed, 4 recruiting, 1 unknown, 1 withdrawn. 7 Phase 1, 6 Phase 3, 4 Phase 4.
By phase and status
Follow Oral semaglutide: new trials by email Literature Review of Oral semaglutide trials Research Report on Oral semaglutide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)
Oral semaglutide, Sitagliptin - Type 2 Diabetes, Heart Failure | | Completed | Brigham and Women's Hospital | 25664 | 2026-01-24 | 2026-09-21 |
A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 Diabetes
Oral semaglutide - Type 2 Diabetes | Phase 3 | Completed | Novo Nordisk A/S | 267 | 2025-12-01 | 2026-08-13 |
Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)
Liraglutide, Oral Semaglutide, Semaglutide - Obesity | Phase 1 | Recruiting | Novo Nordisk A/S | 71 | 2025-11-07 | 2026-07-21 |
A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma
Oral semaglutide, Placebo - Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma | Phase 4 | Recruiting | Glostrup University Hospital, Copenhagen | 126 | 2025-01-01 | 2025-01-24 |
Emulation of the SOUL Diabetes Trial in Healthcare Claims
Oral semaglutide, Sitagliptin - Diabetes Mellitus, Type 2 | | Completed | Brigham and Women's Hospital | 43650 | 2024-10-24 | 2025-05-25 |
Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes
Oral semaglutide, Empagliflozin 10 mg - Type 2 Diabetes Mellitus (T2DM) | Phase 4 | Recruiting | University Medical Centre Ljubljana | 90 | 2024-10-01 | 2026-04-30 |
SEMA-CardioDiab HUNGARY: A Research Study to Understand the Effects of Oral Semaglutide on Blood Sugar Levels, Weight, and Cardiovascular Risk in People With Type 2 Diabetes Patients in Hungary
Oral Semaglutide - Type 2 Diabetes | | Completed | Novo Nordisk A/S | 243 | 2024-09-30 | 2026-08-13 |
GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH
oral semaglutide, Mixed Meal Tolerance Test (MMTT) - Genetic Predisposition, Metabolic Diseases | Phase 4 | Recruiting | Massachusetts General Hospital | 125 | 2024-03-12 | 2026-07-08 |
Oral vs. Subcutaneous Semaglutide in Type 2 Diabetes Mellitus
Oral semaglutide, subcutaneous semaglutide - Diabetes Mellitus Type 2 | | Completed | University of Palermo | 212 | 2024-01-01 | 2025-07-17 |
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Israel, as Part of Local Clinical Practice
Oral semaglutide - Diabetes Mellitus, Type 2 | | Completed | Novo Nordisk A/S | 155 | 2023-03-09 | 2025-10-06 |
A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes in India
Oral semaglutide - Diabetes Mellitus, Type 2 | | Completed | Novo Nordisk A/S | 388 | 2023-02-24 | 2024-09-19 |
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice
Oral Semaglutide - Diabetes Mellitus, Type 2 | | Withdrawn | Novo Nordisk A/S | | 2022-09-30 | 2022-09-29 |
Efficacy of Oral Semaglutide in Overweight or Obesity
oral semaglutide - Obesity, Weight Loss | Phase 4 | Unknown | Asian Institute of Gastroenterology, India | 116 | 2022-07-10 | 2022-07-20 |
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Saudi Arabia, as Part of Local Clinical Practice
Oral semaglutide - Diabetes Mellitus, Type 2 | | Completed | Novo Nordisk A/S | 194 | 2022-04-25 | 2025-09-24 |
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice
Oral semaglutide - Diabetes Mellitus, Type 2 | | Completed | Novo Nordisk A/S | 458 | 2022-04-01 | 2025-09-24 |
Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)
Oral semaglutide, Placebo (semaglutide) - Obesity, Overweight | Phase 3 | Completed | Novo Nordisk A/S | 667 | 2021-09-13 | 2026-05-07 |
A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets
Oral semaglutide - Diabetes Mellitus, Type 2 | Phase 1 | Completed | Novo Nordisk A/S | 14 | 2021-09-10 | 2025-03-11 |
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in the United Kingdom, as Part of Local Clinical Practice
Oral semaglutide - Diabetes Mellitus, Type 2 | | Completed | Novo Nordisk A/S | 336 | 2021-05-12 | 2025-09-24 |
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Japan, as Part of Local Clinical Practice
Oral semaglutide - Diabetes Mellitus, Type 2 | | Completed | Novo Nordisk A/S | 650 | 2021-04-30 | 2025-09-24 |
Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes
Oral semaglutide - Diabetes Mellitus, Type 2 | Phase 3 | Completed | Novo Nordisk A/S | 1606 | 2021-01-15 | 2025-12-09 |
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Conditions studied
Diabetes Mellitus, Type 2 (28) · Obesity (3) · Genetic Predisposition to Disease (1) · Glaucoma (1) · Glaucoma, Open-Angle (1) · Heart Failure (1) · Insulin Resistance (1) · Metabolic Diseases (1) · Overweight (1) · Weight Loss (1)
Sponsors
Novo Nordisk A/S (26) · Brigham and Women's Hospital (2) · Asian Institute of Gastroenterology, India (1) · Glostrup University Hospital, Copenhagen (1) · Massachusetts General Hospital (1) · University Medical Centre Ljubljana (1) · University of Palermo (1)
Countries
United States (8) · Germany (5) · Taiwan (4) · Canada (3) · China (3) · Czechia (3) · Denmark (3) · Hungary (3) · India (3) · Japan (3) · United Kingdom (3) · Algeria (2) · Australia (2) · Israel (2) · Italy (2)
Top investigators
Shirley Wang, PhD, ScM (2) · Anand V Kulkarni, MD DM (1) · Anudeep Katrevula, MD DM (1) · Josephine Li, MD (1) · Nitin Jagtap, MD DNB (1)
Results publications
PMID 39535683, PMID 36932262, PMID 37385279, PMID 38240875, PMID 38468125, PMID 38711208, PMID 38808476, PMID 38861137, PMID 38985161, PMID 38985162, PMID 39052163, PMID 39316289, PMID 40128506, PMID 41066034, PMID 41229720, PMID 41986942, PMID 42592768
NIH funding
2019 (4), 2018 (3), K23DK131345 (1)