29 completed. 29 Phase 2, 7 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 29 | Completed 29 |
| Phase 3 | 7 | Completed 7 |
| Phase 1 | 2 | Completed 2 |
Follow nitazoxanide: new trials by email Literature Review of nitazoxanide trials Research Report on nitazoxanide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nitazoxanide vs Metronidazole for Entamoeba Diarrhea in Children Nitazoxanide, Metronidazole - Entamoeba Histolytica Diarrhea | Phase 2 | Completed | University of Child Health Sciences and Children's Hospital, Lahore | 90 | 2024-04-02 | 2026-08-27 |
| Favipiravir +/- Nitazoxanide: Early Antivirals Combination Therapy in COVID-19 Favipiravir, Nitazoxanide, Nitazoxanide Placebo - Covid19 | Phase 2 | Completed | Coordinación de Investigación en Salud, Mexico | 120 | 2021-10-12 | 2023-03-24 |
| COVID-19 Prophylaxis South Africa (COVER HCW) Nitazoxanide, Sofosbuvir/Daclatasvir - Covid19, SARS-CoV Infection | Phase 2 | Completed | University of Witwatersrand, South Africa | 1950 | 2020-12-08 | 2022-06-07 |
| Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19 Paracetamol, Artesunate-amodiaquine, Pyronaridine-artesunate - COVID-19 | Phase 2 | Completed | Shin Poong Pharmaceutical Co. Ltd. | 192 | 2020-09-03 | 2025-07-28 |
| EAT-DUTA AndroCoV Trial Dutasteride 0.5 mg, Azithromycin, Nitazoxanide - Covid19 | Phase 2 / Phase 3 | Completed | Corpometria Institute | 138 | 2020-06-30 | 2021-01-28 |
| Effects of Early Use of Nitazoxanide in Patients With COVID-19 Nitazoxanide, Placebo - Covid19, Coronavirus | Phase 2 | Completed | Universidade Federal do Rio de Janeiro | 392 | 2020-06-08 | 2020-11-03 |
| Nitazoxanide Therapy for Patients With COVID-19 Pneumonia Nitazoxanide, Placebo - Covid19, Corona Virus Infection | Phase 2 | Completed | Universidade Federal do Rio de Janeiro | 500 | 2020-04-19 | 2021-07-22 |
| Study of Nitazoxanide Compared to Placebo in Subjects With HBeAG-Negative Chronic Hepatitis B Placebo Oral Tablet, Nitazoxanide - Chronic Hepatitis B | Phase 2 | Completed | Romark Laboratories L.C. | 51 | 2019-10-22 | 2023-11-07 |
| An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosis Nitazoxanide 500mg BID - Non-alcoholic Steatohepatitis, Fatty Liver | Phase 2 | Completed | Pinnacle Clinical Research, PLLC | 21 | 2018-12-04 | 2022-06-30 |
| NNITS-Nitazoxanide for Norovirus in Transplant Patients Study Nitazoxanide, Placebo - Gastroenteritis Norovirus | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 31 | 2018-10-15 | 2025-05-21 |
| Early Life Interventions for Childhood Growth and Development In Tanzania Azithromycin Oral Liquid Product, Nitazoxanide Oral Suspension, Nicotinamide - Malnutrition, Stunting | Phase 2 / Phase 3 | Completed | Haydom Lutheran Hospital | 1188 | 2017-09-05 | 2021-05-10 |
| A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis Nitazoxanide, Control - Tuberculosis | Phase 2 | Completed | Weill Medical College of Cornell University | 30 | 2016-02-01 | 2020-08-05 |
| Nitazoxanide Versus Placebo for the Treatment of Hospitalized Subjects With Severe Acute Respiratory Illness Nitazoxanide, Placebo - Severe Acute Respiratory Illness | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 260 | 2014-02-01 | 2018-08-01 |
| Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza Nitazoxanide, Placebo - Influenza | Phase 2 / Phase 3 | Completed | Romark Laboratories L.C. | 624 | 2010-12-01 | 2023-10-12 |
| Efficacy of Nitazoxanide in the Treatment of Chronic Hepatitis C Virus (HCV) Pegylated interferon alfa-2a, Nitazoxanide, Ribavirin - Chronic Hepatitis c | Phase 2 / Phase 3 | Completed | Cairo University | 100 | 2010-12-01 | 2013-05-03 |
| Study of the Impact of Nitazoxanide on Chronic Hepatitis Patients Placebo, Nitazoxanide - Hepatitis C | Phase 2 / Phase 3 | Completed | National Liver Institute, Egypt | 200 | 2010-09-01 | 2014-09-30 |
| A Safety and Tolerability Study of Nitazoxanide in HIV-HCV Treatment Failures Nitazoxanide With Pegylated Interferon And Ribavirin - Hepatitis C Infection, HIV Infection | Phase 1 / Phase 2 | Completed | National Institutes of Health Clinical Center (CC) | 8 | 2010-08-01 | 2021-10-05 |
| Nitazoxanide Plus Ribavirin and Peginterferon for Therapy of Treatment Naive HCV Genotype 1 and HIV Coinfected Subjects Nitazoxanide (NTZ), Pegylated interferon alfa-2a (PEG), Ribavirin (RBV) - HIV Infection, Hepatitis C Infection | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 68 | 2010-01-01 | 2021-11-04 |
| Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Hepatitis C Patients Nitazoxanide, Placebo, Peginterferon alfa-2a - Chronic Hepatitis C | Phase 2 | Completed | Romark Laboratories L.C. | 112 | 2008-03-01 | 2014-02-10 |
| Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin for the Treatment of Hepatitis C Nitazoxanide, Placebo, Peginterferon alfa-2a - Chronic Hepatitis C | Phase 2 | Completed | Romark Laboratories L.C. | 64 | 2007-07-01 | 2014-05-08 |
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Hepatitis C, Chronic (8) · COVID-19 (6) · HIV Infections (4) · Hepatitis C (4) · AIDS-Related Opportunistic Infections (2) · Coronavirus Infections (2) · Cryptosporidiosis (2) · Rotavirus Infections (2) · Adenoviridae Infections (1) · Caliciviridae Infections (1) · Fatty Liver (1) · Gastroenteritis (1) · Growth Disorders (1) · Hepatitis B, Chronic (1) · Influenza, Human (1)
Romark Laboratories L.C. (11) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Universidade Federal do Rio de Janeiro (2) · Cairo University (1) · Coordinación de Investigación en Salud, Mexico (1) · Corpometria Institute (1) · Haydom Lutheran Hospital (1) · National Institutes of Health Clinical Center (CC) (1) · National Liver Institute, Egypt (1) · Pinnacle Clinical Research, PLLC (1) · Shin Poong Pharmaceutical Co. Ltd. (1) · University of Child Health Sciences and Children's Hospital, Lahore (1) · University of Witwatersrand, South Africa (1) · Weill Medical College of Cornell University (1)
United States (9) · Egypt (7) · Brazil (3) · South Africa (3) · Mexico (2) · Haiti (1) · Pakistan (1) · Puerto Rico (1) · Singapore (1) · Tanzania (1) · Thailand (1)
Asem Elfert, MD (4) · Yehia El-Gohary, MD (3) · Arthur Berman, DO (2) · Ira Jacobson, MD (2) · Mona Abu-Zekry, MD (2) · Norman Gitlin, MD (2) · Patricia RM Rocco, MD, PhD (2) · Stephen Harrison, MD (2) · Ahmed Aijaz, MD (1) · Aijaz Ahmed, MD (1) · Alejandra Ramirez Venegas, M.D. (1) · Andy Goren, MD (1) · Arnold L Lentnek, M.D. (1) · Arturo Galindo Fraga, M.D. (1)
PMID 16829296, PMID 23890273, PMID 24852376, PMID 29982218, PMID 30753384, PMID 32071052, PMID 33602926, PMID 34473343, PMID 34582462, PMID 35492335, PMID 35869526, PMID 36963502, PMID 37261117, PMID 37382971, PMID 39032770, PMID 40385586, PMID 41232946, PMID 42177030, PMID 42309304