5 completed, 5 terminated, 4 unknown, 1 not yet recruiting. 13 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 5, Terminated 4, Unknown 3, Withdrawn 1 |
Follow Nasal High Flow: new trials by email Literature Review of Nasal High Flow trials Research Report on Nasal High Flow
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Upper Airway Morphology and Physiology During Graded Positive Pressure and Nasal High Flow: An MRI Study Nasal High Flow, Continuous Positive Airway Pressure - Chronic Obstructive Pulmonary Disease (COPD) | Not yet recruiting | Klinikum Dortmund Wirbelsäulenchirurgie | 20 | 2026-10-01 | 2026-10-21 | |
| Effects on Ventilation With NHF and Asymmetrical Nasal Cannulas AIRVO 2 - Chronic Obstructive Pulmonary Disease | Not applicable | Unknown | Kliniken Essen-Mitte | 20 | 2023-01-19 | 2023-12-01 |
| Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom Nasal High Flow - Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease | Not applicable | Unknown | Royal Free Hospital NHS Foundation Trust | 54 | 2022-03-28 | 2023-12-14 |
| ROX Index and ROX Vector to Predict Nasal High Flow / Continuous Positive Airway Pressure Failure in Neonates Nasal high flow, Continuous Positive Airway Pressure - Predictive Value of Tests | Unknown | Erebouni Medical Center | 100 | 2021-09-06 | 2021-09-24 | |
| RENOVATE Fibrosis:HFNC Versus NIPPV in Acute Respiratory Failure in Patients With Pulmonary Fibrosis High Flow Nasal Catheter, Noninvasive positive pressure ventilation (NIPPV) - Acute Respiratory Failure, Pulmonary Fibrosis | Not applicable | Terminated | Hospital do Coracao | 3 | 2020-12-10 | 2021-08-16 |
| RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF High Flow Nasal Cannula, Standard respiratory support - Care, Palliative, Respiratory Failure | Not applicable | Terminated | Hospital do Coracao | 3 | 2020-12-01 | 2021-08-16 |
| High-Flow Nasal Oxygen Cannula Compared to Non-Invasive Ventilation in Adult Patients With AcuTE Respiratory Failure High Flow Nasal Catheter, Noninvasive ventilation - Respiratory Insufficiency, Respiratory Failure | Not applicable | Completed | Hospital do Coracao | 1801 | 2019-11-01 | 2024-05-20 |
| Nasal High Flow Therapy in Surgical Patients with Unrecognized Obstructive Sleep Apnea Nasal High Flow, Usual Care - Obstructive Sleep Apnea, Sleep Disordered Breathing | Not applicable | Completed | University Health Network, Toronto | 22 | 2019-10-01 | 2025-01-13 |
| Nasal High Flow to Maintain the Benefits of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients Nasal high flow - Chronic Obstructive Pulmonary Disease | Not applicable | Terminated | ADIR Association | 2 | 2019-07-22 | 2023-11-15 |
| Sonographic Evaluation of Diaphragmatic Function Under Nasal High-flow (NHF) and Non-invasive Ventilation (NIV) in Respiratory Insufficiency Nasal high flow, NIV - Respiratory Insufficiency | Not applicable | Completed | Klinikum Emden | 35 | 2019-07-01 | 2025-07-03 |
| NHF vs NIV in Patients With Acute Exacerbation of COPD Nasal High Flow, Non-Invasive Ventilation - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Not applicable | Unknown | Evangelismos Hospital | 498 | 2018-04-15 | 2020-02-20 |
| Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Nasal high flow - Chronic Obstructive Pulmonary Disease | Not applicable | Completed | Temple University | 10 | 2017-07-20 | 2018-04-19 |
| Effects of Nasal High Flow Therapy on Ventilation and Gas Exchange in Healthy Newborns Nasal High Flow - Respiratory Support | Not applicable | Completed | Research Center of Maternal and Child Health Protection, Armenia | 20 | 2015-05-01 | 2019-10-31 |
| Assessment of the Tolerability of Dry Airflow in the Nasal Cavity During Sleep Nasal High Flow - Healthy Adults | Not applicable | Withdrawn | Johns Hopkins University | 2015-01-01 | 2017-08-08 | |
| Efficacy of High Flow Therapy in COPD At Home Nasal High Flow - COPD | Terminated | Johns Hopkins University | 8 | 2013-08-15 | 2017-08-08 | |
| Nasal High Flow at Acute Hart Failure Nasal high flow, Conventional nasal oxygen - Decompensated Heartfailure, Cardio-renal Syndrom | Not applicable | Terminated | University Hospital Regensburg | 46 | 2010-09-01 | 2019-09-26 |
Pulmonary Disease, Chronic Obstructive (7) · Respiratory Insufficiency (4) · Dyspnea (1) · Obesity Hypoventilation Syndrome (1) · Pulmonary Fibrosis (1) · Sleep Apnea Syndromes (1) · Sleep Apnea, Obstructive (1)
Hospital do Coracao (3) · Johns Hopkins University (2) · ADIR Association (1) · Erebouni Medical Center (1) · Evangelismos Hospital (1) · Kliniken Essen-Mitte (1) · Klinikum Dortmund Wirbelsäulenchirurgie (1) · Klinikum Emden (1) · Research Center of Maternal and Child Health Protection, Armenia (1) · Royal Free Hospital NHS Foundation Trust (1) · Temple University (1) · University Health Network, Toronto (1) · University Hospital Regensburg (1)
Germany (4) · Brazil (3) · United States (3) · Armenia (2) · Canada (1) · France (1) · Greece (1) · Hong Kong (1) · Malaysia (1) · Singapore (1) · United Kingdom (1)
Leticia Kawano-Dourado, MD (3) · Alexandre B Cavalcanti, MD (2) · Israel Maia, MD (2) · Jason Kirkness, PhD (2) · Antoine Cuvelier, MD, PhD, Prof (1) · Carlos R Carvalho, MD (1) · Fernando Zampieri, MD (1) · Frances Chung, MBBS FRCPC (1) · Francis-Edouard Gravier, Msc (1) · Georg Nilius (1) · Israel S Maia, MD (1) · Lara P Kretzer, MD (1) · Laurent Brochard, MD (1) · Maxime Patout, MD, Msc (1)
PMID 26339486, PMID 26947372, PMID 26976648, PMID 27015801, PMID 27668173, PMID 27815367, PMID 27997805, PMID 28104830, PMID 28794144, PMID 38046839, PMID 39111544, PMID 39657981, PMID 41734013