19 completed, 3 recruiting, 2 withdrawn, 1 not yet recruiting. 16 Phase 2, 5 Not applicable, 5 Phase 3, 3 Phase 1, 1 Phase 4.
Follow milk-thistle extract: new trials by email Literature Review of milk-thistle extract trials Research Report on milk-thistle extract
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Misocholic Tablets for Non-Viral Elevated Liver Enzymes Misocholic Tab, Placebo, Silymarin (Silybum marianum) - Alcohol-Related Liver Disease, Drug-Induced Liver Injury | Phase 3 | Not yet recruiting | Hanoi Medical University | 60 | 2026-09-15 | 2026-09-22 |
| Effect of the Combined Application of Cynara Scolymus, Silybum Marianum, Curcuma Longa, and Glycyrrhiza Glabra in Improving Metabolic Associated Fatty Liver Disease : a Randomized Clinical Trial Combination of cynara scolymus, silybum marianum, curcuma longa, and glycyrrhiza glabra, Placebo maltodextrin - Metabolic-associated Fatty Liver Disease (MAFLD) | Phase 2 | Recruiting | Li Lab,MD | 100 | 2025-03-01 | 2025-04-23 |
| Beneficial Effect of Silymarin in Ulcerative Colitis Silymarin, Mesalamine, Azathioprine - Ulcerative Colitis | Phase 2 | Recruiting | Tanta University | 44 | 2025-02-01 | 2025-03-05 |
| Milk Thistle Clinical Trial in Pediatric NAFLD Milk thistle (MT), Placebo, Lifestyle Modification - Non-Alcoholic Fatty Liver Disease (NAFLD) | Phase 2 | Recruiting | University Hospitals Cleveland Medical Center | 20 | 2024-12-19 | 2026-01-27 |
| Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases Silymarin, Placebo - Rheumatoid Arthritis, Psoriatic Arthritis | Not applicable | Unknown | Phramongkutklao College of Medicine and Hospital | 72 | 2024-02-01 | 2024-02-26 |
| Silymarin Effects on Fatty Liver in Type 2 Diabetics Silymarin (Silybum marianum) - Type 2 Diabetes, Fatty Liver | Not applicable | Completed | University of Mosul | 120 | 2024-01-02 | 2026-10-13 |
| Impact of Silymarin Adjunct Therapy on Proteinuria in Type 2 Diabetic Patients on RAS Inhibitors Silymarin, Placebo - Type 2 Diabetes Mellitus | Phase 2 | Completed | Lahore General Hospital | 70 | 2022-02-25 | 2024-05-22 |
| Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin Milk Thistle (MT), Lactobacillus Gasseri (LAC), Exercise (EX) - Obesity | Phase 3 | Completed | Kyle Flack | 42 | 2021-02-24 | 2023-07-28 |
| Milk Thistle in Body Dysmorphic Disorder Milk Thistle, Placebo - Body Dysmorphic Disorder | Phase 2 | Withdrawn | University of Chicago | 2016-10-01 | 2022-12-28 | |
| Relative Bioavailability of Two Different Milk Thistle Formulations Product B® IsaGenesis®, IsaGenesis® - Healthy | Not applicable | Completed | University of Florida | 12 | 2015-09-01 | 2018-06-19 |
| Management of Decompensated HCV Cirrhotic Patients Sofosbuvir 400mg (Sovaldi) + Daclatasvir 60 mg (Daklinza) + Ribavirin 200 mg (Rebetol), vitamin K (Phytomenadione) 10 mg+ furosemide and spironolactone (Lasilactone) 50 mg + milk thistle (Silymarin) 140 mg + Albumin infusion - Decompensated Cirrhosis | Not applicable | Completed | Zagazig University | 80 | 2015-06-01 | 2018-12-05 |
| Milk Thistle in Trichotillomania in Children and Adults Milk Thistle, Placebo - Trichotillomania, Hair Pulling Disorder | Phase 2 | Completed | University of Chicago | 22 | 2015-03-01 | 2020-11-20 |
| Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk Aloe vera with cactus, Cranberry, Green tea extract - Hyperoxaluria | Not applicable | Completed | University of Wisconsin, Madison | 45 | 2015-02-01 | 2016-10-27 |
| Milk Thistle in Pathological Gambling Placebo, Milk Thistle - Pathological Gambling, Gambling Disorder | Phase 2 | Completed | University of Chicago | 55 | 2015-01-01 | 2026-07-07 |
| Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma Silymarin, Placebo, chemotherapy - Upper GI Cancer, Cisplatin Adverse Reaction | Phase 2 / Phase 3 | Completed | Tehran University of Medical Sciences | 30 | 2013-08-01 | 2015-05-13 |
| Evaluating the Renoprotective Effect of Milk Thistle Extract on Patients With Type II Diabetic Nephropathy placebo, Milk Thistle extract - Diabetic Nephropathy | Phase 2 | Completed | Shiraz University of Medical Sciences | 60 | 2010-10-01 | 2012-06-25 |
| Randomized Controlled Trial of Silymarin in Asthma Oral Silymarin, Oral Silymarin, maintenance dose, Placebo - Atopic Asthma | Phase 2 / Phase 3 | Withdrawn | Vanderbilt University | 2010-09-01 | 2014-02-24 | |
| Siliphos in Advanced Hepatocellular Carcinoma Silybin - Advanced Hepatocellular Carcinoma | Phase 1 | Completed | Abby Siegel | 3 | 2010-02-01 | 2013-11-25 |
| Safety, Metabolism, and Antioxidant Activity of Silymarin and Green Tea Extract in Patients With Chronic Hepatitis C silymarin, green tea extract (EGCG) - Chronic Hepatitis C, Oxidative Stress | Phase 1 | Completed | University of North Carolina, Chapel Hill | 28 | 2009-11-01 | 2017-04-18 |
| Comparative Effects of Milk Thistle Extract With Vitamin-E in Hemodialysis Patients Milk Thistle extract, vit E, vit E + Milk Thistle extract - Hemodialysis, End Stage Renal Disease | Phase 2 | Completed | Shiraz University of Medical Sciences | 80 | 2009-06-01 | 2011-01-24 |
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Diabetes Mellitus, Type 2 (3) · Hepatitis C, Chronic (3) · Non-alcoholic Fatty Liver Disease (3) · Fatty Liver (2) · Hepatitis (2) · Arthritis, Psoriatic (1) · Arthritis, Rheumatoid (1) · Asthma (1) · Body Dysmorphic Disorders (1) · Chemical and Drug Induced Liver Injury (1) · Colitis, Ulcerative (1) · Diabetes Mellitus (1) · Diabetic Nephropathies (1) · Gambling (1) · Gastrointestinal Neoplasms (1)
University of Chicago (3) · National Center for Complementary and Integrative Health (NCCIH) (2) · Shiraz University of Medical Sciences (2) · University of Maryland, Baltimore (2) · Abby Siegel (1) · Hanoi Medical University (1) · Kyle Flack (1) · Lahore General Hospital (1) · Li Lab,MD (1) · Madaus Inc (1) · National Institutes of Health Clinical Center (CC) (1) · Phramongkutklao College of Medicine and Hospital (1) · Tanta University (1) · Tehran University of Medical Sciences (1) · University Hospitals Cleveland Medical Center (1)
United States (14) · Iran (3) · Egypt (2) · China (1) · Iraq (1) · Pakistan (1) · Thailand (1) · Vietnam (1)
Jon E Grant, JD, MD, MPH (3) · Ghazal Vessal, PharmD, PhD (2) · Jamshid Roozbeh, MD (2) · K. Rajender Reddy, MD (2) · Michael Fried, MD (2) · Nezam Afdhal, MD (2) · Victor Navarro, MD (2) · Abby Siegel, MD, MS (1) · Amr S Hanafy, md (1) · Bahram Shahriari, MD (1) · Dalia R Mohammed ElAfify, Asst.Prof (1) · George T Strickland, MD, PhD (1) · George T Strickland, MD, PhD, (1) · Hussein A ElAmin Hammam, Professor (1) · John S Markowitz, Pharm.D. (1)
PMID 20127732, PMID 22770926, PMID 22797645, PMID 29273470, PMID 30758786, PMID 31536511, PMID 36082508, PMID 36130734, PMID 36508737, PMID 37916745, PMID 38478366, PMID 38674860, PMID 38879879
R21AT003892 (1)