2 completed, 1 not yet recruiting, 1 terminated, 1 withdrawn. 5 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 2, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
Follow milk-thistle extract: new trials by email Literature Review of milk-thistle extract trials Research Report on milk-thistle extract
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Misocholic Tablets for Non-Viral Elevated Liver Enzymes Misocholic Tab, Placebo, Silymarin (Silybum marianum) - Alcohol-Related Liver Disease, Drug-Induced Liver Injury | Phase 3 | Not yet recruiting | Hanoi Medical University | 60 | 2026-09-15 | 2026-09-22 |
| Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin Milk Thistle (MT), Lactobacillus Gasseri (LAC), Exercise (EX) - Obesity | Phase 3 | Completed | Kyle Flack | 42 | 2021-02-24 | 2023-07-28 |
| Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma Silymarin, Placebo, chemotherapy - Upper GI Cancer, Cisplatin Adverse Reaction | Phase 2 / Phase 3 | Completed | Tehran University of Medical Sciences | 30 | 2013-08-01 | 2015-05-13 |
| Randomized Controlled Trial of Silymarin in Asthma Oral Silymarin, Oral Silymarin, maintenance dose, Placebo - Atopic Asthma | Phase 2 / Phase 3 | Withdrawn | Vanderbilt University | 2010-09-01 | 2014-02-24 | |
| Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis Silymarin, Lactose monohydrate - Acute Hepatitis A, Acute Hepatitis B | Phase 2 / Phase 3 | Terminated | University of Maryland, Baltimore | 70 | 2008-10-01 | 2021-04-23 |
Asthma (1) · Chemical and Drug Induced Liver Injury (1) · Gastrointestinal Neoplasms (1) · Hepatitis (1) · Motor Activity (1) · Non-alcoholic Fatty Liver Disease (1) · Obesity (1) · Weight Loss (1)
Hanoi Medical University (1) · Kyle Flack (1) · Tehran University of Medical Sciences (1) · University of Maryland, Baltimore (1) · Vanderbilt University (1)
United States (2) · Egypt (1) · Iran (1) · Vietnam (1)
George T Strickland, MD, PhD, (1) · Mohamed Hashem, MD (1) · Samer El-Kamary, MD, MPH (1) · Simin Dashti-Khavidaki, Dr (1) · Tina V. Hartert, MD, MPH (1)