5 completed, 1 active not recruiting, 1 recruiting, 1 terminated. 4 Not applicable, 4 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 2, Recruiting 1, Terminated 1 |
| Phase 3 | 4 | Completed 3, Active not recruiting 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow Methylcobalamin: new trials by email Literature Review of Methylcobalamin trials Research Report on Methylcobalamin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patients Mecobalamin IV Injection, Mecobalamin Tablets - Vitamin B12 Deficiency, Renal Failure , Chronic | Not applicable | Completed | Jinnah Hospital | 60 | 2026-02-22 | 2026-08-24 |
| Combination Gerotherapeutic Interventions for Healthspan Improvement Rapamycin, Naltrexone, Metformin - Healthspan Improvement, Aging | Phase 3 | Active not recruiting | AgelessRx | 30 | 2025-07-23 | 2026-03-16 |
| Effect of Methylcobalamin and Cyanocobalamin Consumption on Vitamin B12 Nutritional Status Methylcobalamin, Cyanocobalamin group, Control group - Vitamin B12 Nutritional Deficiency | Not applicable | Recruiting | Fundació Eurecat | 54 | 2023-09-09 | 2024-10-30 |
| Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients methylcobalamin, Folic Acid, Placebo for methylcobalamin - Post Operative Cognitive Dysfunction | Not applicable | Terminated | Xijing Hospital | 40 | 2019-01-10 | 2021-08-04 |
| A Randomized Controlled Trial of Mecobalamin Injection and Tablet Treatment Efficacy on Mild to Moderate Diabetic Peripheral Neuropathy methylcobalamin - Diabetic Neuropathies | Phase 2 | Unknown | Peking University Third Hospital | 30 | 2017-12-25 | 2020-05-04 |
| Clinical Trial of Ultra-high Dose Methylcobalamin for ALS methylcobalamin, saline solution - Amyotrophic Lateral Sclerosis | Phase 3 | Completed | Eisai Co., Ltd. | 130 | 2017-11-01 | 2025-03-26 |
| Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial Inactive lozenge, Methylcobalamin - Vitamin B12 Deficiency | Not applicable | Completed | University of West London | 50 | 2012-03-01 | 2014-05-20 |
| Trial of Methyl B12 on Behavioral and Metabolic Measures in Children With Autism Methyl B12, Placebo - Autistic Disorder | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 57 | 2010-01-01 | 2017-02-24 |
| Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism methylcobalamin, saline placebo - Autistic Disorder | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 30 | 2005-07-01 | 2019-10-09 |
Autistic Disorder (2) · Vitamin B 12 Deficiency (2) · Amyotrophic Lateral Sclerosis (1) · Cardiovascular Diseases (1) · Child Development Disorders, Pervasive (1) · Diabetic Neuropathies (1) · Hyperhomocysteinemia (1) · Motor Neuron Disease (1) · Renal Insufficiency (1) · Renal Insufficiency, Chronic (1)
University of California, San Francisco (2) · AgelessRx (1) · Eisai Co., Ltd. (1) · Fundació Eurecat (1) · Jinnah Hospital (1) · Peking University Third Hospital (1) · University of West London (1) · Xijing Hospital (1)
United States (3) · China (2) · Japan (1) · Pakistan (1) · Spain (1) · United Kingdom (1)
Amalia A Tsiami, PhD (1) · Antoni Caimari, PhD (1) · David C Chappell, PhD (1) · Jenell Decker, MD (1) · Lize Xiong, M.D., Ph.D. (1) · Mukarram Hussain (1) · Robert L Hendren, D.O. (1) · Robert L. Hendren, DO (1) · Ryuji Kaji, MD (1) · Shafiq Cheema, MBBS, MD (1) · Stefanie Morgan, PhD (1)
PMID 25982504, PMID 26889605, PMID 30578206, PMID 34282267, PMID 35532908, PMID 9843082