24 completed. 24 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 24 | Completed 24 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 1 | Completed 1 |
Follow LV: new trials by email Literature Review of LV trials Research Report on LV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of SGN-LIV1A Plus Pembrolizumab for Patients With Locally-Advanced or Metastatic Triple-Negative Breast Cancer ladiratuzumab vedotin, Pembrolizumab - Triple Negative Breast Neoplasms | Phase 1 / Phase 2 | Completed | Seagen Inc. | 185 | 2018-02-27 | 2025-12-12 |
| Study of Nanoliposomal Irinotecan (Nal-IRI)-Containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma nal-IRI, 5 fluorouracil, Leucovorin - Pancreatic Cancer | Phase 2 | Completed | Ipsen | 56 | 2015-10-19 | 2022-10-10 |
| Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer 5-Fluorouracil, Leucovorin, Irinotecan - Colon Cancer | Phase 2 | Completed | UNC Lineberger Comprehensive Cancer Center | 100 | 2014-05-06 | 2025-05-18 |
| Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer oxaliplatin, leucovorin calcium, irinotecan hydrochloride - Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas | Phase 2 | Completed | Yale University | 46 | 2014-03-25 | 2026-03-06 |
| Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer metformin hydrochloride, oxaliplatin, leucovorin calcium - Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas | Phase 2 | Completed | Case Comprehensive Cancer Center | 50 | 2013-02-21 | 2021-08-10 |
| Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab panitumumab, irinotecan hydrochloride, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 16 | 2013-02-01 | 2025-02-05 |
| Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer aflibercept, oxaliplatin, leucovorin - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 56 | 2012-11-14 | 2025-02-05 |
| Phase II Trial Evaluating OS With Therasphere® + 2nd-Line FOLFOX in Pancreatic Liver Mets FOLFOX7 (Folinic acid, 5-Fluorouracil, and Oxaliplatin), TheraSpheres - Liver Cancer, Pancreatic Cancer | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 9 | 2012-04-01 | 2017-03-03 |
| Individual Dosage Selection of Irinotecan (CPT-11) Based on UGT1A1 Genotype in Metastatic Colorectal Cancer Patients Irinotecan Injection [Camptosar], 5-fluorouracil, Leucovorin - Metastatic Colorectal Cancer | Phase 2 / Phase 3 | Completed | The Affiliated Hospital of the Chinese Academy of Military Medical Sciences | 583 | 2012-03-08 | 2017-03-30 |
| Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer fluorouracil, leucovorin calcium, oxaliplatin - Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction | Phase 1 / Phase 2 | Completed | City of Hope Medical Center | 6 | 2012-02-01 | 2017-05-31 |
| Study of S-1 Plus LV for Advanced Gastric Cancer S-1, LV - Gastric Cancer | Phase 2 | Completed | Sun Yat-sen University | 39 | 2011-07-01 | 2014-03-18 |
| Bevacizumab and Combination Chemotherapy Before Surgery in Treating Patients With Locally Advanced Esophageal or Stomach Cancer bevacizumab, oxaliplatin, leucovorin calcium - Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction | Phase 2 | Completed | Fox Chase Cancer Center | 20 | 2011-04-27 | 2022-09-07 |
| Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer oxaliplatin, leucovorin calcium, fluorouracil - Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Stomach | Phase 2 | Completed | National Cancer Institute (NCI) | 124 | 2009-09-01 | 2016-01-25 |
| Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment fluorouracil, leucovorin calcium, vorinostat - Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | Phase 2 | Completed | Roswell Park Cancer Institute | 58 | 2009-07-01 | 2014-06-23 |
| Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 148 | 2009-03-01 | 2017-01-27 |
| Irinotecan/Oxaliplatin/5-Fluorouracil/Leucovorin/Cetuximab As First Line Treatment In Colorectal Cancer Irinotecan, Leukovorin, Oxaliplatin - Metastatic Colorectal Cancer | Phase 2 | Completed | University Hospital of Crete | 30 | 2007-07-01 | 2015-09-28 |
| Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL) L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone - Recurrent Childhood Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Completed | Children's Oncology Group | 134 | 2005-02-01 | 2017-12-12 |
| Study of FOLFIRI Plus Bevacizumab in Colorectal Cancer Patients 5-Fluorouracil, Bevacizumab, Leucovorin - Colorectal Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 49 | 2005-01-01 | 2011-10-21 |
| Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer cetuximab, bevacizumab, oxaliplatin - Adenocarcinoma of the Rectum, Mucinous Adenocarcinoma of the Colon | Phase 2 | Completed | National Cancer Institute (NCI) | 66 | 2004-11-01 | 2015-07-27 |
| Combination of CPT-11 and LoHP vs Combination of 5-FU, Leucovorin and LoHP as 1st Line Treatment in Gastric Patients Irinotecan, Oxaliplatin, Fluorouracil - Gastric Cancer | Phase 2 | Completed | Hellenic Oncology Research Group | 110 | 2004-07-01 | 2009-09-28 |
Showing 20 of 24. Sign in to see all of them.
Stomach Neoplasms (6) · Colonic Neoplasms (5) · Colorectal Neoplasms (4) · Pancreatic Neoplasms (4) · Rectal Neoplasms (4) · Adenocarcinoma Of Esophagus (2) · Esophageal Neoplasms (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Dendritic Cell Sarcoma, Interdigitating (1) · Diarrhea (1) · Esophageal Squamous Cell Carcinoma (1) · Liver Neoplasms (1) · Lymphoma, Large B-Cell, Diffuse (1)
National Cancer Institute (NCI) (5) · Children's Oncology Group (2) · John Hays (2) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · Fox Chase Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Hellenic Oncology Research Group (1) · Ipsen (1) · M.D. Anderson Cancer Center (1) · Roswell Park Cancer Institute (1) · Seagen Inc. (1) · Sun Yat-sen University (1) · The Affiliated Hospital of the Chinese Academy of Military Medical Sciences (1)
United States (20) · Australia (3) · Canada (2) · China (2) · Greece (2) · Puerto Rico (2) · Spain (2) · Germany (1) · South Korea (1)
John Hays, MD (2) · Allyson Ocean (1) · Crystal Denlinger (1) · David Bajor, MD (1) · David Ebb (1) · David I. Rosenthal, MD (1) · Deirdre Cohen (1) · Elizabeth Raetz, MD (1) · Hanna Sannoff, MD (1) · Ioannis Boukovinas, MD (1) · Jian-Ming Xu, M.D. (1) · Jill Lacy, MD (1) · John Souglakos, MD (1) · Kristel Apolinario, PharmD (1)
PMID 21208843, PMID 23293700, PMID 24077846, PMID 27913881, PMID 28419486, PMID 30117142, PMID 30525443, PMID 30957229, PMID 32154021, PMID 33957442, PMID 34162404, PMID 34750990, PMID 38900452
U10CA098543 (4), 2015 (1), 2017 (1), N01CM00038 (1), N01CM00070 (1), N01CM00071 (1), N01CM62201 (1), N01CM62204 (1), P30CA006927 (1), P30CA016087 (1), P30CA016359 (1), U10CA023318 (1), U10CA031946 (1), U10CA180886 (1)