7 completed, 4 withdrawn, 2 not yet recruiting, 2 unknown. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 7, Withdrawn 4, Not yet recruiting 2, Unknown 2, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Evaluation of Lifitegrast Ophthalmic Solution 5.0% in Dry Eye Disease Using In Vivo Confocal Microscopy Lifitegrast Ophthalmic Solution 5.0% (Xiidra) - Dry Eye | Phase 4 | Not yet recruiting | Toyos Clinic | 30 | 2026-04-01 | 2026-05-01 |
| This is a Single Center, Open-label Prospective Study to Evaluate the Effect of Xiidra® (Lifitegrast Ophthalmic Solution 5.0%) on Tear Film Biomarkers in Dry Eye (Xiidra®) Lifitegrast Ophthalmic Solution 5.0% - Ocular Surface Disease, Dry Eye Syndrome (DES) | Phase 4 | Not yet recruiting | Pittsburgh Research Institute | 36 | 2026-03-01 | 2026-03-24 |
| A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment Vevye®, Xiidra® - Dry Eye Disease | Phase 4 | Completed | Hoffmann-La Roche | 378 | 2025-07-09 | 2026-07-27 |
| Lifitegrast 5% for the Treatment of Dry Eye In Habitual Soft Contact Lens Wearers Lifitegrast 5% Ophthalmic Solution, Lifitegrast Ophthalmic Solution Vehicle - Dry Eye | Phase 4 | Completed | State University of New York College of Optometry | 32 | 2022-09-22 | 2025-01-14 |
| The Effect of Xiidra on Comfort and Dryness in Symptomatic Contact Lens Wearers Xiidra - Dry Eye | Phase 4 | Completed | University of Waterloo | 45 | 2021-07-07 | 2025-05-04 |
| Ocular Inflammation in Cataract Patients and Response to Treatment With Xiidra Lifitegrast 5% Ophthalmic Solution - Dry Eye | Phase 4 | Withdrawn | Bucci Laser Vision Institute | 2021-05-31 | 2023-07-27 | |
| The Chronology of Lifitegrast Effect on Anterior Surface Rehabilitation (CLEAR) Study Lifitegrast 5% Ophthalmic Solution - Dry Eye | Phase 4 | Completed | Research Insight LLC | 100 | 2021-03-17 | 2021-10-12 |
| Treatment Regimens in Meibomian Gland Dysfunction Lifitegrast Ophthalmic, Systane Free, Lipiflow - Dry Eye Syndromes | Phase 4 | Completed | Tauber Eye Center | 60 | 2021-03-02 | 2023-04-12 |
| Effect of Lifitegrast 5% on Tear Film Markers Lifitegrast 5% Ophthalmic Solution - Dry Eye, Dry Eye Syndromes | Phase 4 | Withdrawn | Weill Medical College of Cornell University | 2021-03-01 | 2021-02-16 | |
| Efficacy of Xiidra in Dry Eye Disease After Collagen Cross Linking Xiidra 5% Ophthalmic Solution - Corneal Disease | Phase 4 | Unknown | Benha University | 40 | 2021-02-01 | 2021-09-16 |
| Xiidra vs. Xiidra + Dextenza Treatment for Dry Eye Disease Lifitegrast 5% Ophthalmic Solution, Dexamethasone Intracanalicular Insert, 0.4mg with Lifitegrast 5% Ophthalmic Solution - Dry Eye Syndromes | Phase 4 | Terminated | Eye Surgeons of Indiana | 5 | 2020-08-01 | 2026-10-27 |
| Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days nanomicellular cyclosporine 0.09%, Lifitegrast - Dry Eye | Phase 4 | Unknown | Toyos Clinic | 100 | 2020-02-01 | 2022-10-20 |
| Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease Lifitegrast - Ocular Discomfort, Ocular Inflammation | Phase 4 | Withdrawn | University of Alabama at Birmingham | 2019-01-01 | 2019-05-17 | |
| Use of 5.0% Lifitegrast Ophthalmic Solution for the Treatment of Dry Eye Disease in Contact Lens Wearers Lifitegrast - Contact Lens Dry Eye | Phase 4 | Withdrawn | University of Alabama at Birmingham | 2018-11-01 | 2018-10-25 | |
| Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness Lifitegrast - Contact Lens, Contact Lens Discomfort | Phase 4 | Completed | EV Clinical Trials | 21 | 2016-12-16 | 2018-09-28 |
| Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms Lifitegrast - Dry Eye | Phase 4 | Completed | Lifelong Vision Foundation | 30 | 2016-12-12 | 2018-03-19 |
Dry Eye Syndromes (16) · Keratoconjunctivitis Sicca (2) · Cataract (1) · Corneal Diseases (1) · Xerophthalmia (1)
Toyos Clinic (2) · University of Alabama at Birmingham (2) · Benha University (1) · Bucci Laser Vision Institute (1) · EV Clinical Trials (1) · Eye Surgeons of Indiana (1) · Hoffmann-La Roche (1) · Lifelong Vision Foundation (1) · Pittsburgh Research Institute (1) · Research Insight LLC (1) · State University of New York College of Optometry (1) · Tauber Eye Center (1) · University of Waterloo (1) · Weill Medical College of Cornell University (1)
United States (13) · Canada (1) · United Arab Emirates (1)
Christopher Starr, MD (1) · Damon Dierker, OD, FAAO (1) · Danielle Iacono, OD (1) · Frank A Bucci, Jr., MD (1) · Jason J Nichols, OD PhD MPH (1) · Jay S Pepose, MD, PhD (1) · John Hovanesian, MD (1) · Kelly K Nichols, OD MPH PhD (1) · Leanne T Labriola, DO, MBA (1) · Lyndon Jones, PhD, FCOptom (1) · Melissa Toyos, MD (1) · Rolando Toyos, MD (1) · Tarek Elhamaky (1)