66 completed, 18 active not recruiting, 14 terminated, 12 unknown. 69 Phase 2, 29 Phase 3, 12 Phase 1, 11 Phase 4, 9 Not applicable.
Follow Leuprolide Acetate: new trials by email Literature Review of Leuprolide Acetate trials Research Report on Leuprolide Acetate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial Abiraterone Acetate, Biospecimen Collection, Leuprolide Acetate - Recurrent Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 202 | 2026-08-04 | 2026-09-18 |
| Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer Biopsy, Bone Scan, Computed Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Active not recruiting | Roswell Park Cancer Institute | 3 | 2024-12-19 | 2026-08-07 |
| Adjuvant Rezvilutamide in Combination With Androgen Deprivation Therapy in Androgen Receptor-positive, High-risk Salivary Duct Carcinoma Rezvilutamide, Leuprolide Acetate - Salivary Gland Neoplasm Duct | Phase 2 | Recruiting | Peking University First Hospital | 37 | 2024-10-10 | 2025-09-23 |
| Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors Biospecimen Collection, Chest Radiography, Computed Tomography - Adult Ovarian Granulosa Cell Tumor | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 17 | 2024-02-08 | 2026-07-28 |
| A Neoadjuvant Study of Abiraterone Acetate, Leuprolide Acetate, and Belzutifan in Men With Regional Prostate Cancer Neoadjuvant treatment - Prostate Cancer | Phase 2 | Withdrawn | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2024-01-01 | 2024-03-18 | |
| Testing the Anti-cancer Drug Darolutamide in Patients With Testosterone-Driven Salivary Gland Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Salivary Gland Carcinoma, Metastatic Salivary Gland Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 21 | 2023-07-20 | 2026-07-31 |
| Kisspeptin Administration Subcutaneously to Patients With IHH kisspeptin 112-121, leuprolide acetate - Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 36 | 2023-02-03 | 2026-07-13 |
| Randomized Study to Evaluate MACE in Patients With Prostate Cancer Treated With Relugolix or Leuprolide Acetate Relugolix, Leuprolide Acetate - Prostate Cancer | Phase 3 | Completed | Sumitomo Pharma America, Inc. | 387 | 2023-01-28 | 2026-06-15 |
| RElugolix VErsus LeUprolide Cardiac Trial Radiation therapy, Leuprolide, Relugolix - Biochemically Recurrent Prostate Carcinoma, Localized Prostate Carcinoma | Phase 2 | Active not recruiting | Emory University | 94 | 2022-06-06 | 2026-02-12 |
| Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer Leuprolide acetate, Goserelin acetate, Triptorelin acetate - Prostate Cancer | Phase 2 | Unknown | Fudan University | 160 | 2022-04-01 | 2022-03-16 |
| A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy Enzalutamide, Rucaparib camsylate, Placebo - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 61 | 2021-10-14 | 2026-02-05 |
| Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer Abiraterone Acetate, Bicalutamide, Degarelix - Castration-Sensitive Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 70 | 2021-05-04 | 2026-01-28 |
| Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer Abiraterone Acetate, Apalutamide, Leuprolide Acetate - Metastatic Prostate Adenocarcinoma, Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation | Phase 2 | Active not recruiting | Jonsson Comprehensive Cancer Center | 28 | 2021-03-17 | 2026-02-05 |
| Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study Darolutamide, Goserelin Acetate, Leuprolide Acetate - Prostate Carcinoma | Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 27 | 2021-03-01 | 2026-07-28 |
| Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the Treatment of Biochemically Recurrent Prostate Cancer, RESTART Study Apalutamide, Degarelix, Leuprolide Acetate - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2020-11-24 | 2021-01-20 | |
| Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging 3-Dimensional Conformal Radiation Therapy, Apalutamide, Computed Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 804 | 2020-10-08 | 2026-08-19 |
| Real-life Study of Patients After 3-months of Leuprorelin 5mg Implant in Prostate Cancer Leuprolide Acetate - Prostate Cancer | Withdrawn | RECORDATI GROUP | 2020-03-01 | 2024-10-31 | ||
| Neurobiology of Bulimia Nervosa Estradiol, Micronized progesterone, Leuprolide Acetate - Bulimia Nervosa | Phase 2 | Completed | University of North Carolina, Chapel Hill | 10 | 2020-02-24 | 2022-07-26 |
| Comparison Between Two Different Protocols in Polycystic Ovary Symdrome Women Undergoing Intra-cytoplasmic Injection Cetrorelix, Leuprolide Acetate - Polycystic Ovary Syndrome | Phase 4 | Unknown | Assiut University | 150 | 2019-12-07 | 2020-03-25 |
| REGN2810 Followed by Chemoimmunotherapy for Newly Metastatic Hormone-sensitive Prostate Cancer REGN2810, Degarelix, Leuprolide Acetate - Prostate Cancer Metastatic | Phase 2 | Active not recruiting | Mark Stein | 26 | 2019-05-16 | 2025-04-25 |
Showing 20 of 125. Sign in to see all of them.
Prostatic Neoplasms (79) · Breast Neoplasms (7) · Neoplasms (5) · Leiomyoma (4) · Infertility (3) · Polycystic Ovary Syndrome (3) · Alzheimer Disease (2) · Depression, Postpartum (2) · Obesity (2) · Acanthosis Nigricans (1) · Adenocarcinoma (1) · Amenorrhea (1) · Breast Neoplasms, Male (1) · Bulimia (1) · Bulimia Nervosa (1)
M.D. Anderson Cancer Center (8) · National Cancer Institute (NCI) (8) · Mayo Clinic (5) · University of Colorado, Denver (4) · City of Hope Medical Center (3) · NCIC Clinical Trials Group (3) · SWOG Cancer Research Network (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · University Magna Graecia (3) · University of Washington (3) · Abbott (2) · Alliance for Clinical Trials in Oncology (2) · Dana-Farber Cancer Institute (2) · ECOG-ACRIN Cancer Research Group (2) · Eastern Cooperative Oncology Group (2)
United States (94) · Canada (13) · Italy (7) · United Kingdom (7) · China (6) · France (5) · Austria (4) · Finland (4) · Slovakia (4) · South Korea (4) · Spain (4) · Australia (3) · Belgium (3) · Brazil (3) · Czechia (3)
Christopher Logothetis (3) · Fulvio Zullo, MD,PhD (3) · Kenneth Pienta, MD (2) · Richard L. Bowen, MD (2) · Roberta Venturella, MD (2) · A. O. Sartor, MD (1) · Alan L Ho (1) · Alicia K Morgans (1) · Amar Kishan (1) · Ana M. Aparicio, MD (1) · Angela Smith, M.D. (1) · Anthony V. D'Amico, MD, PhD (1) · Antonios Likourezos, M.P.H., M.A. (1) · Arpit Rao, MD (1)
PMID 38421243, PMID 10663329, PMID 17194907, PMID 17405995, PMID 17405996, PMID 18037582, PMID 18291508, PMID 19167733, PMID 20435244, PMID 20818327, PMID 21601197, PMID 21751904, PMID 22006050, PMID 22056152, PMID 22282904, PMID 22344198, PMID 22723326, PMID 22931259, PMID 24354113, PMID 25242417, PMID 25385669, PMID 25691677, PMID 25732157, PMID 25847934, PMID 26014295, PMID 29457758, PMID 29631362, PMID 30811282, PMID 31668850, PMID 31899823, PMID 33002429, PMID 33002431, PMID 33390282, PMID 33496795, PMID 34385241, PMID 34481017, PMID 35587650, PMID 35780048, PMID 35810050, PMID 36782063, PMID 37119051, PMID 37372414, PMID 37713020, PMID 37851874, PMID 37922910, PMID 38320143, PMID 38320501, PMID 38421252, PMID 38494380, PMID 38583574
P30CA015083 (4), U10CA032102 (3), P30CA016672 (2), P30CA033572 (2), U10CA180820 (2), U10CA180868 (2), 2016 (1), 2017 (1), 2023 (1), N01CM00039 (1), N01CM62201 (1), N01CM62202 (1), N01CM62205 (1), N01CM62206 (1), P30CA008748 (1)