275 completed, 50 terminated, 44 unknown, 28 active not recruiting. 221 Phase 2, 124 Phase 3, 90 Phase 1, 20 Not applicable, 3 Phase 4.
Follow Leucovorin Calcium: new trials by email Literature Review of Leucovorin Calcium trials Research Report on Leucovorin Calcium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of ONO-4578 Versus Placebo in Combination With Nivolumab and Chemotherapy in Participants With Gastric Cancer, Esophagogastric Junction Cancer, or Esophageal Adenocarcinoma ONO-4578, Placebo, Nivolumab - Gastric Cancer, Esophagogastric Junction Cancer | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 600 | 2027-02-01 | 2026-09-14 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Not yet recruiting | SWOG Cancer Research Network | 90 | 2026-10-14 | 2026-10-13 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| A Placebo-controlled Trial of Folinic Acid in Children With ASD Folinic Acid, Placebo - Autism Spectrum Disorder | Phase 2 | Recruiting | Prof. Adi Aran | 150 | 2026-06-23 | 2026-06-22 |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 35 | 2026-02-16 | 2026-08-19 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Colorectal Adenocarcinoma, Stage III Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 24 | 2025-06-23 | 2026-09-09 |
| FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery Balstilimab, Biospecimen Collection, Botensilimab - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 26 | 2025-05-20 | 2026-06-29 |
| A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome | Phase 1 | Recruiting | Children's Oncology Group | 36 | 2025-02-04 | 2026-08-25 |
| A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene. PF-07985045, Gemcitabine, Nab-paclitaxel - Carcinoma, Pancreatic Ductal, Colorectal Neoplasms | Phase 1 | Terminated | Pfizer | 30 | 2024-12-10 | 2026-05-22 |
| A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation. PF-07934040, Gemcitabine, Nab-paclitaxel - Carcinoma, Pancreatic Ductal, Colorectal Neoplasms | Phase 1 | Active not recruiting | Pfizer | 64 | 2024-06-27 | 2026-10-13 |
| Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) Binimetinib, Biopsy Procedure, Biospecimen Collection - Advanced Biliary Tract Carcinoma, Advanced Gallbladder Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 17 | 2024-02-09 | 2026-10-19 |
| Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer Atezolizumab, Biospecimen Collection, Capecitabine - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 2 | 2023-12-06 | 2026-07-01 |
| Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis Aldesleukin, Biopsy Procedure, Biospecimen Collection - Clinical Stage IV Gastric Cancer AJCC v8, Gastric Adenocarcinoma | Phase 1 | Active not recruiting | Mayo Clinic | 15 | 2023-11-29 | 2026-07-01 |
| Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma Biospecimen Collection, Computed Tomography, Endoscopic Ultrasound - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 99 | 2023-11-21 | 2026-10-01 |
| FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer Balstilimab, Bevacizumab, Biospecimen Collection - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 / Phase 2 | Active not recruiting | City of Hope Medical Center | 20 | 2023-05-03 | 2026-09-01 |
| Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma Biospecimen Collection, Computed Tomography, Core Biopsy - Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 56 | 2023-03-07 | 2026-05-22 |
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Colonic Neoplasms (149) · Colorectal Neoplasms (149) · Rectal Neoplasms (147) · Lymphoma (41) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (40) · Leukemia (34) · Stomach Neoplasms (32) · Pancreatic Neoplasms (31) · Burkitt Lymphoma (28) · Neoplasm Metastasis (26) · Adenocarcinoma Of Esophagus (22) · HIV Infections (22) · Acquired Immunodeficiency Syndrome (21) · Esophageal Neoplasms (20) · Lymphoma, Non-Hodgkin (13)
National Cancer Institute (NCI) (63) · Children's Oncology Group (27) · Alliance for Clinical Trials in Oncology (24) · Memorial Sloan Kettering Cancer Center (20) · National Institute of Allergy and Infectious Diseases (NIAID) (16) · City of Hope Medical Center (14) · European Organisation for Research and Treatment of Cancer - EORTC (14) · SWOG Cancer Research Network (13) · GERCOR - Multidisciplinary Oncology Cooperative Group (11) · Federation Francophone de Cancerologie Digestive (10) · UNICANCER (8) · Eastern Cooperative Oncology Group (7) · Mayo Clinic (7) · Medical Research Council (7) · Roswell Park Cancer Institute (7)
United States (314) · Canada (59) · France (52) · Puerto Rico (40) · Australia (31) · United Kingdom (29) · Switzerland (25) · Germany (24) · Italy (23) · Belgium (19) · Netherlands (19) · New Zealand (14) · Austria (12) · Portugal (8) · Sweden (8)
Feinberg J (5) · Leonard B. Saltz, MD (5) · Marwan Fakih (5) · Henry C. Pitot, MD (4) · Nancy E. Kemeny, MD (4) · Tanya Trippett, MD (4) · Aimery de Gramont, MD (3) · Al B. Benson, MD, FACP (3) · Bach Ardalan, MD (3) · Claus-Henning Koehne, MD (3) · Heinz-Josef Lenz (3) · Howard S. Hochster, MD (3) · Luft B (3) · Michel Ducreux, MD, PhD (3) · Steven R. Alberts, MD (3)
PMID 31268130, PMID 21997132, PMID 33356421, PMID 37890117, PMID 39121442, PMID 23007406, PMID 23233662, PMID 26590194, PMID 28006055, PMID 29284596, PMID 31811950, PMID 32085892, PMID 33242441, PMID 36306483, PMID 36603187, PMID 38315963, PMID 38446568, PMID 40315406, PMID 41671463, PMID 42085640, PMID 10442378, PMID 10499612, PMID 10550154, PMID 11098486, PMID 11426549, PMID 11600602, PMID 11913730, PMID 12047964, PMID 12204666, PMID 12239143, PMID 12782596, PMID 12860947, PMID 12963697, PMID 14665611, PMID 15042678, PMID 15353542, PMID 15470715, PMID 15558814, PMID 15637138, PMID 15646530, PMID 15659500, PMID 15677624, PMID 15774775, PMID 15939923, PMID 16009951, PMID 16009952, PMID 16009958, PMID 16105981, PMID 16110021, PMID 16230673
U10CA098543 (19), U10CA031946 (14), U10CA180886 (14), U10CA032102 (13), P30CA033572 (8), U10CA021115 (8), U10CA180821 (7), U10CA180820 (6), U10CA180888 (6), P30CA015083 (5), U10CA012027 (5), P30CA008748 (4), P30CA014089 (4), P30CA016672 (4), P30CA036727 (4)