6 completed, 5 terminated, 3 unknown, 2 active not recruiting. 13 Not applicable, 5 Phase 2, 1 Phase 1, 1 Phase 3.
Follow Intraoperative Radiotherapy: new trials by email Literature Review of Intraoperative Radiotherapy trials Research Report on Intraoperative Radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer External Beam Radiation Therapy, Intraoperative Radiation Therapy, Pembrolizumab - Head and Neck Carcinoma of Unknown Primary, Locally Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 45 | 2022-05-12 | 2026-07-24 |
| Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation. Intraoperative Radiotherapy, Oncoplastic partial mastectomy - IORT-Intra-Operative Radiation Therapy | Not applicable | Terminated | Saint John's Cancer Institute | 5 | 2021-12-16 | 2025-12-31 |
| Intraoperative Radiotherapy in Patients With Brain Metastases Intraoperative radiotherapy - Brain Metastases | Not applicable | Recruiting | Parc de Salut Mar | 25 | 2021-05-05 | 2025-06-06 |
| Comparison Between IORT and Postoperative Radiotherapy in Breast Conserving Surgery intraoperative radiotherapy, postoperative radiotherapy - Quality of Life | Not applicable | Terminated | Xiangyun Zong | 80 | 2021-03-01 | 2025-06-02 |
| IORT on Borderline Resectable Pancreatic Cancer Intraoperative radiotherapy - Borderline Resectable Pancreatic Cancer | Phase 2 | Suspended | Universita di Verona | 100 | 2019-10-01 | 2024-05-07 |
| Intraoperative Electron Radiotherapy for Low-risk Early Breast Cancer intraoperative radiotherapy, whole breast irradiation - Breast Cancer | Not applicable | Suspended | University Hospital Heidelberg | 101 | 2019-10-01 | 2026-05-05 |
| Xoft® Intraoperative Radiotherapy (IORT) for Patients With Early-Stage Breast Cancer Intraoperative radiotherapy - Breast Cancer, Breast Cancer, Invasive Ductal | Terminated | University of Louisville | 10 | 2019-09-10 | 2023-05-12 | |
| Focal Intraoperative Radiotherapy of Brain Metastases Intraoperative Radiotherapy - Brain Metastases, Adult, Central Nervous System Metastases | Phase 2 | Terminated | AC Camargo Cancer Center | 10 | 2019-05-02 | 2023-07-27 |
| Intraoperative Radiotherapy After the Resection of Brain Metastases Intraoperative Radiotherapy - Brain Metastases | Not applicable | Unknown | Universitätsmedizin Mannheim | 50 | 2017-03-28 | 2022-06-03 |
| Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme Standard surgery, Intraoperative radiotherapy, Radiochemotherapy - Glioblastoma | Phase 3 | Active not recruiting | Universitätsmedizin Mannheim | 314 | 2016-12-09 | 2025-10-14 |
| Intra-operative Radiotherapy For Women With Ductal Carcinoma in Situ Breast Cancer Intraoperative Radiotherapy - Breast Neoplasms | Not applicable | Unknown | Liao Ning | 222 | 2014-10-01 | 2015-03-17 |
| Comparison of Intra-operative Radiotherapy With Post-operative Radiotherapy for Women With Ductal Carcinoma in Situ Intraoperative Radiotherapy, Whole breast radiation - Breast Neoplasms | Not applicable | Unknown | Liao Ning | 74 | 2014-06-01 | 2015-03-17 |
| Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery Intraoperative Radiation Therapy, Laboratory Biomarker Analysis - Stage IA Breast Cancer, Stage IIA Breast Cancer | Not applicable | Active not recruiting | University of California, San Francisco | 1259 | 2012-05-18 | 2026-03-18 |
| Single Fraction Intraoperative Radiotherapy Intraoperative Radiotherapy - Invasive Ductal and Invasive Lobular Breast Carcinoma, Stage 0 Breast Carcinoma | Not applicable | Completed | St. Joseph Hospital of Orange | 250 | 2012-02-01 | 2022-05-11 |
| Kypho-IORT: Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases intraoperative radiotherapy - Tumors | Phase 2 | Completed | Universitätsmedizin Mannheim | 18 | 2011-01-01 | 2022-07-22 |
| Prospective Phase II Study of Intraoperative Radiotherapy (IORT) in Elderly Patients with Small Breast Cancer intraoperative radiotherapy - Breast Neoplasms, Breast Diseases | Not applicable | Completed | Universitätsmedizin Mannheim | 591 | 2011-01-01 | 2025-03-30 |
| Intraoperative Radiotherapy for Early Stage Breast Cancer Intraoperative Radiotherapy - Breast Cancer | Not applicable | Completed | Hoag Memorial Hospital Presbyterian | 200 | 2010-06-01 | 2024-10-15 |
| Targeted Intra-Operative Radiotherapy for the Management of Ductal Carcinoma In-Situ of the Breast Intraoperative radiotherapy - Breast Cancer | Not applicable | Terminated | University of Southern California | 36 | 2007-10-01 | 2025-11-06 |
| A Prospective Single Arm Study of Intraoperative Radiotherapy for Locally Advanced or Recurrent Rectal Cancer intraoperative radiotherapy - Malignant Rectal Neoplasm, Recurrent Tumor | Phase 2 | Completed | Peter MacCallum Cancer Centre, Australia | 32 | 2004-07-01 | 2025-05-31 |
| Randomized Trial on Intraoperative Radiotherapy Full Dose Vs External Radiotherapy external fractionated radiotherapy, intraoperative radiotherapy - Carcinoma Breast | Not applicable | Completed | European Institute of Oncology | 1305 | 2000-11-01 | 2013-05-08 |
Showing 20 of 21. Sign in to see all of them.
Breast Neoplasms (10) · Brain Neoplasms (3) · Neoplasms (2) · Breast Carcinoma In Situ (1) · Breast Diseases (1) · Carcinoma (1) · Carcinoma, Ductal, Breast (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Lobular (1) · Glioblastoma (1) · Neoplasm Recurrence, Local (1) · Pancreatic Neoplasms (1) · Rectal Neoplasms (1) · Recurrence (1) · Sarcoma (1)
Universitätsmedizin Mannheim (4) · Liao Ning (2) · AC Camargo Cancer Center (1) · European Institute of Oncology (1) · Hoag Memorial Hospital Presbyterian (1) · Ohio State University Comprehensive Cancer Center (1) · Parc de Salut Mar (1) · Peter MacCallum Cancer Centre, Australia (1) · Radiation Therapy Oncology Group (1) · Saint John's Cancer Institute (1) · St. Joseph Hospital of Orange (1) · Universita di Verona (1) · University Hospital Heidelberg (1) · University of California, San Francisco (1) · University of Louisville (1)
United States (9) · Germany (5) · China (4) · Brazil (2) · Canada (2) · Italy (2) · Spain (2) · Australia (1) · South Korea (1) · United Kingdom (1)
Liao Ning, MD,PhD (2) · Douglas G Castro, MD (1) · Dukagjin M Blakaj, MD, PhD (1) · Frank A. Giordano, MD (1) · Heather Macdonald, MD (1) · Janie L Weng Grumley, MD (1) · Kevin Petrecca, MD (1) · Lawrence Wagman, M.D. (1) · Michael Alvarado, MD (1) · Peter V Chen, MD (1) · Peter W. T. Pisters, MD (1) · Sam Ngan (1) · Sperk Elena, MD (1) · Stefanie Brehmer, MD (1)
PMID 29528443, PMID 16934611, PMID 22569123, PMID 24006012, PMID 24225155, PMID 24635869, PMID 25614945, PMID 28069018, PMID 28962909, PMID 29800971, PMID 30094718, PMID 31654248, PMID 32487184, PMID 33183307, PMID 33593311, PMID 33845035, PMID 34459500, PMID 41345599, PMID 42372746