4 recruiting, 3 active not recruiting, 3 terminated, 2 suspended. 7 Phase 2, 4 Phase 3, 3 Not applicable, 3 Phase 1.
Follow this drug Literature Review of Image guided radiation therapy trials Research Report on Image guided radiation therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer Daily adaptive radiation therapy, Image guided radiation therapy - Squamous Cell Cancer of Head and Neck (SCCHN) | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2025-10-15 | 2026-03-04 |
| Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer Best Practice, Biospecimen Collection, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | NRG Oncology | 98 | 2025-06-23 | 2026-08-17 |
| Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer Biospecimen Collection, Cemiplimab, Computed Tomography - Eyelid Squamous Cell Carcinoma, Recurrent Eyelid Squamous Cell Carcinoma | Phase 3 | Suspended | National Cancer Institute (NCI) | 420 | 2025-02-18 | 2026-10-20 |
| Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial Biopsy, Biospecimen Collection, Computed Tomography - Prostate Adenocarcinoma | Phase 2 | Recruiting | Sean Sachdev | 50 | 2024-09-06 | 2026-06-05 |
| Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases Computed Tomography, Image Guided Radiation Therapy, Positron Emission Tomography - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 1 | Suspended | City of Hope Medical Center | 24 | 2024-08-25 | 2026-10-20 |
| Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer Biospecimen Collection, Carboplatin, Chest Radiography - Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma | Phase 2 | Withdrawn | ECOG-ACRIN Cancer Research Group | 2024-04-12 | 2024-07-25 | |
| Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer Carboplatin, Cisplatin, Computed Tomography - Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 474 | 2023-07-12 | 2026-08-17 |
| De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer Biopsy Procedure, Biospecimen Collection, Cisplatin - Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 / Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 384 | 2019-10-09 | 2026-07-02 |
| Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery Carboplatin, Cisplatin, Docetaxel - Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7, Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7 | Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 82 | 2019-03-12 | 2026-09-14 |
| Nab-paclitaxel and Gemcitabine Hydrochloride Followed by Radiation Therapy Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery Fluorouracil, Gemcitabine, Image Guided Radiation Therapy - Pancreatic Adenocarcinoma, Resectable Pancreatic Carcinoma | Phase 2 | Completed | OHSU Knight Cancer Institute | 20 | 2016-01-21 | 2023-09-06 |
| Radiation Therapy vs. Observation Following Gemcitabine and Cisplatin for Inoperable Localized Liver Cancer Image Guided Radiation Therapy - Stage III Intrahepatic Cholangiocarcinoma, Stage IVA Intrahepatic Cholangiocarcinoma | Phase 3 | Terminated | NRG Oncology | 1 | 2014-09-29 | 2026-07-13 |
| Trametinib, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery 3-Dimensional Conformal Radiation Therapy, Carboplatin, Image Guided Radiation Therapy - Recurrent Lung Non-Small Cell Carcinoma, Stage III Lung Non-Small Cell Cancer AJCC v7 | Phase 1 | Terminated | National Cancer Institute (NCI) | 16 | 2013-10-28 | 2023-05-06 |
| Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer Image Guided Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Recurrent Lung Non-Small Cell Carcinoma, Stage II Non-Small Cell Lung Cancer AJCC v7 | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 146 | 2012-09-17 | 2026-09-16 |
| Hypofractionated Radiation Therapy in Prostate Cancer Intensity modulated radiation therapy, Volumetric modulated arc therapy, Image guided radiation therapy - Malignant Neoplasm of Prostate, Local Disease | Not applicable | Unknown | Thomas Zilli | 170 | 2012-09-01 | 2020-05-19 |
| Development of Real-time Image-guided Radiotherapy Image guided radiation therapy - Breast Cancer, Lung Cancer | Not applicable | Terminated | Fox Chase Cancer Center | 159 | 2012-05-17 | 2020-03-02 |
Squamous Cell Carcinoma of Head and Neck (3) · Carcinoma (2) · Carcinoma, Non-Small-Cell Lung (2) · Hypopharyngeal Neoplasms (2) · Laryngeal Neoplasms (2) · Lung Neoplasms (2) · Mouth Neoplasms (2) · Oropharyngeal Neoplasms (2) · Breast Neoplasms (1) · Carcinoma, Squamous Cell (1) · Cholangiocarcinoma (1) · Nasopharyngeal Carcinoma (1) · Neoplasm Metastasis (1) · Prostatic Neoplasms (1) · Skin Neoplasms (1)
NRG Oncology (3) · National Cancer Institute (NCI) (3) · ECOG-ACRIN Cancer Research Group (2) · City of Hope Medical Center (1) · Fox Chase Cancer Center (1) · M.D. Anderson Cancer Center (1) · OHSU Knight Cancer Institute (1) · Sean Sachdev (1) · Thomas Zilli (1) · University Health Network, Toronto (1)
United States (12) · Canada (5) · Australia (1) · Belgium (1) · Finland (1) · Israel (1) · Netherlands (1) · Portugal (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1)
Charles B Simone (1) · David M Brizel (1) · Gina Vaccaro (1) · Heath D Skinner (1) · Nabil F Saba (1) · Neil D Gross (1) · Sean Sachdev (1) · Steven H Lin (1) · Sue S Yom (1) · Theodore Hong (1) · Thomas Zilli, Dr (1) · Yi-Jen Chen (1) · Zhongxing Liao (1)
PMID 26503201, PMID 35080076, PMID 39615497, PMID 41137728
U10CA180868 (4), U10CA180820 (2), P01CA021239 (1), P30CA016672 (1), P30CA033572 (1), P30CA060553 (1), P50CA070907 (1), U01CA062461 (1), U19CA021239 (1), UG1CA189867 (1), UM1CA186688 (1), UM1CA186712 (1)