13 completed, 10 unknown, 9 recruiting, 4 active not recruiting. 48 Phase 2, 3 Phase 3, 2 Phase 1.
Follow Hyperthermic Intraperitoneal Chemotherapy: new trials by email Literature Review of Hyperthermic Intraperitoneal Chemotherapy trials Research Report on Hyperthermic Intraperitoneal Chemotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HIPEC Priming Followed by Serplulimab Plus SOX/XELOX in Locally Advanced Gastric Cancer Hyperthermic Intraperitoneal Chemotherapy, Serplulimab, S-1 - Locally Advanced Gastric Cancer, Gastric Adenocarcinoma | Phase 2 | Recruiting | Shanghai Changzheng Hospital | 48 | 2026-07-13 | 2026-10-22 |
| Heated Versus Aerosol-based Laparoscopic Chemotherapy for Cancer That Has Spread to the Peritoneum (Abdominal Lining) Heated intra-peritoneal chemotherapy, Aerosolized intra-peritoneal chemotherapy - Peritoneal (Metastatic) Cancer, Peritoneal Carcinomatosis | Phase 2 | Recruiting | Patrick Wagner, MD, FACS | 200 | 2026-01-05 | 2026-02-27 |
| A Prospective, Phase II Clinical Study of HIPEC Combined With NIPS and Tislelizumab Conversion Therapy for Gastric Cancer With Peritoneal Metastasis With Positive Cytology Alone or PCI Score ≤10 HIPEC, NIPS, Paclitaxel Injection, S-1, tislelizumab - Gastric Cancer Peritoneal Metastases | Phase 2 | Not yet recruiting | Hebei Medical University | 30 | 2025-12-12 | 2025-12-26 |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for Gastric Cancer at High Risk of Peritoneal Recurrence Biopsy Procedure, Biospecimen Collection, Cisplatin - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Enrolling by invitation | Mayo Clinic | 16 | 2025-12-03 | 2026-07-01 |
| INTERACT Stomach-II intraperitoneal chemotherapy - Peritoneal Metastases From Gastric Cancer | Phase 2 | Recruiting | Erasmus Medical Center | 55 | 2025-10-01 | 2026-10-21 |
| The Safety and Effectiveness of Hyperthermic Intraperitoneal Chemotherapy Combined With Intravenous Chemotherapy for Peritoneal Metastatic Pancreatic Cancer, a Phase II Clinical Trial Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cisplatin + Systemic AG Chemotherapy - Hyperthermic Intraperitoneal Chemotherapy, Peritoneal Metastatic Pancreatic Cancer | Phase 2 | Recruiting | Shanghai Zhongshan Hospital | 90 | 2025-04-03 | 2025-04-27 |
| A Clinical Study Evaluating the Efficacy of Systemic Chemotherapy and Immune Checkpoint Inhibitors Combined With Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer Patients With Peritoneal Metastasis HIPEC, SOX, Immune Checkpoint Inhibitors - Gastric Cancer | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 34 | 2025-02-15 | 2025-04-11 |
| Secondary Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for PARP Inhibitors Resistance Patients Secondary cytoreduction, Hyperthermic intraperitoneal chemotherapy - Ovarian Cancer | Phase 2 | Not yet recruiting | Fudan University | 94 | 2024-08-31 | 2024-08-09 |
| The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM HIPEC, Systemic therapy - Gastric Cancer, Metastatic | Phase 2 | Active not recruiting | The First Affiliated Hospital with Nanjing Medical University | 50 | 2024-05-31 | 2025-07-16 |
| Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Nab-paclitaxel - Metastatic Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 2 | Active not recruiting | Mayo Clinic | 40 | 2024-02-15 | 2026-10-15 |
| Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study Cisplatin, Computed Tomography, Gastrectomy - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Recruiting | Mayo Clinic | 40 | 2023-04-20 | 2026-04-08 |
| HIPEC Combined Gastrectomy in Patients With Advanced Gastric Cancer Received Neoadjuvant Chemotherapy HIPEC - Gastric Cancer, Peritoneal Metastases | Phase 2 / Phase 3 | Not yet recruiting | Zhixin Cao | 200 | 2023-01-01 | 2022-12-06 |
| Intraperitoneal Chemotherapy Guided by the Detection of DNA in Peritoneal Lavage Fluid in Patients With Gastric Cancer Intraperitoneal chemotherapy, Adjuvant systemic chemotherapy - Gastric Cancer | Phase 2 | Unknown | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 68 | 2022-06-28 | 2022-08-11 |
| Intraperitoneal Chemotherapy in Gastric Cancer With Peritoneal Carcinomatosis Intraperitoneal chemotherapy - Gastric Cancer, Peritoneal Carcinomatosis | Phase 2 | Unknown | Instituto do Cancer do Estado de São Paulo | 30 | 2022-06-01 | 2023-03-23 |
| Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma Atezolizumab, Bevacizumab, Biospecimen Collection - Peritoneal Malignant Mesothelioma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2022-03-22 | 2026-10-26 |
| HIPEC-AS in Patients With Peritoneal Metastasis of the Stomach or Esophagogastric Junction HIPEC, Paclitaxel-albumin, Tegafur-gimeracil-oteracil potassium - Stomach Neoplasms, Peritoneal Metastases | Phase 2 | Not yet recruiting | Xuefei.Wang | 157 | 2021-10-01 | 2021-10-27 |
| Trial Evaluating Feasibility and Quality of Life of Second Look Laparoscopy With Hyperthermic Intraperitoneal Chemotherapy Second look laparoscopy reassessment surgery (SLLRS), HIPEC with Carboplatin, FACT-O Quality of Life Questionnaire - Ovarian Epithelial Cancer Stage I, Ovarian Epithelial Cancer Stage II | Phase 2 | Completed | Wake Forest University Health Sciences | 10 | 2021-05-20 | 2026-08-10 |
| PHASE II EVALUATION OF CYTOREDUCTION SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (CRS/HIPEC) IN GASTRIC CANCER Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy - Gastric Adenocarcinoma | Phase 2 | Recruiting | Banner Health | 30 | 2021-04-16 | 2026-05-01 |
| Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial) HIPEC, intravenous chemotherapy - Hyperthermic Intraperitoneal Chemotherapy, Neoadjuvant Chemotherapy | Phase 2 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 80 | 2020-12-01 | 2022-02-18 |
| Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Locally Advanced Gastric Cancer D2 radical gastrectomy, SOX neoadjuvant or postoperative chemotherapy, Hyperthermic intraperitoneal chemotherapy (HIPEC) - Malignant Neoplasm of Stomach | Phase 2 | Unknown | Wuhan University | 100 | 2020-04-01 | 2020-04-14 |
Showing 20 of 48. Sign in to see all of them.
Stomach Neoplasms (16) · Peritoneal Neoplasms (12) · Ovarian Neoplasms (9) · Fallopian Tube Neoplasms (6) · Carcinoma, Ovarian Epithelial (5) · Colorectal Neoplasms (4) · Appendiceal Neoplasms (3) · Neoplasm Metastasis (3) · Carcinoma (2) · Mesothelioma (2) · Neoplasms (2) · Pancreatic Neoplasms (2) · Desmoplastic Small Round Cell Tumor (1) · Drug-Related Side Effects and Adverse Reactions (1) · Exploratory Behavior (1)
Wuhan University (4) · Mayo Clinic (3) · Wake Forest University Health Sciences (3) · Fudan University (2) · Hospices Civils de Lyon (2) · M.D. Anderson Cancer Center (2) · Albert Einstein College of Medicine (1) · Andrea Jewell (1) · Banner Health (1) · Bay Area Gynecology Oncology (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Catholic University of the Sacred Heart (1) · Erasmus Medical Center (1) · Guangdong Provincial Hospital of Traditional Chinese Medicine (1) · Hebei Medical University (1)
United States (16) · China (15) · Belgium (2) · Germany (2) · Netherlands (2) · Austria (1) · Brazil (1) · France (1) · Mexico (1) · South Korea (1) · Spain (1)
Aaron S Mansfield (1) · Andre Roncon Dias, MD, PhD (1) · Andrea Hayes-Jordan, MD (1) · Andrea Jewell, MD (1) · Anna Fagotti, MD, PhD (1) · Armando Sardi, M.D. (1) · Brian D Badgwell (1) · Cornelius A. Thiels, DO, MBA (1) · Dionisios Vrochides, MD PhD FACS (1) · Edward Levine (1) · Gabriella Ferrandina, MD (1) · Garrett Nash, MD, MPH (1) · Ida Paris, MD (1)
PMID 19169758, PMID 21424369, PMID 24378877, PMID 27633880, PMID 28273222, PMID 29263704, PMID 30131226, PMID 32556731, PMID 32667582, PMID 33198674, PMID 35262624, PMID 35712968, PMID 36608383, PMID 37596449, PMID 37673112, PMID 37690994, PMID 40115934, PMID 40953882
2009 (2), 2015 (1), 2016 (1), 2025 (1), P30CA012197 (1), U10CA180821 (1)