5 completed, 2 recruiting, 2 terminated, 2 withdrawn. 4 Phase 1, 3 Not applicable, 2 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 2, Recruiting 1, Withdrawn 1 |
| Not applicable | 3 | Completed 2, Not yet recruiting 1 |
| Phase 4 | 2 | Terminated 2 |
| Phase 2 | 1 | Recruiting 1 |
Follow Hyperglycemic clamp: new trials by email Literature Review of Hyperglycemic clamp trials Research Report on Hyperglycemic clamp
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alpelisib Challenge Test (ACT) Alpelisib 300 mg, Alpelisib Challenge Test (ACT): Mixed Meal Tolerance Test (MMTT) after taking alpelisib, Hyperglycemic clamp - Insulin Resistance, Type 2 Diabetes | Phase 1 | Recruiting | Columbia University | 15 | 2026-09-02 | 2026-09-03 |
| Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes Hyperglycemic clamp - Type 1 Diabetes Mellitus | Not applicable | Not yet recruiting | University of California, San Diego | 20 | 2025-02-01 | 2024-12-10 |
| The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction Caloric Restriction, Hyperglycemic clamp - Type2diabetes | Phase 2 | Recruiting | Adrian Vella | 20 | 2022-12-15 | 2026-05-28 |
| Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp Hyperglycemic Clamp, Kisspeptin-10, Placebo - Metabolic Disease | Phase 1 | Withdrawn | Massachusetts General Hospital | 2022-06-03 | 2024-08-14 | |
| Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Hyperinsulinemic Euglycemic Clamp and 2H20, Hyperglycemic Clamp, Oral Glucose Tolerance Test - McCune-Albright Syndrome, Fibrous Dysplasia | Withdrawn | Yale University | 2018-08-07 | 2019-09-04 | ||
| Regulation of Insulin Secretion by the GLP-1 Receptor Exendin (9-39), Dexamethasone, Hyperglycemic Clamp - Insulin Secretion | Phase 4 | Terminated | VA Office of Research and Development | 6 | 2018-07-01 | 2024-12-12 |
| Type 2 Diabetes and the Brain in Adolescents Hyperglycemic clamp, Hyperinsulinemic Euglycemic clamp - Type 2 Diabetes Mellitus, Obesity | Not applicable | Completed | Nemours Children's Clinic | 18 | 2017-12-05 | 2019-09-09 |
| Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes Oral Glucose Tolerance Test, Hyperglycemic Clamp, Isoglycemic Intravenous Glucose Test - IGT - Impaired Glucose Tolerance, T2D | Completed | Yale University | 100 | 2017-03-01 | 2023-02-23 | |
| GLP-1 Effects on Insulin and Glucagon in PTDM Glucagon-like peptide-1 (GLP-1), Isotonic saline, Hyperglycemic clamp - Post-transplant Diabetes Mellitus | Not applicable | Completed | Oslo University Hospital | 24 | 2014-10-01 | 2016-03-31 |
| The Role of Endocannabinoids in Insulin Production and Action Nabilone, CP-945,598, hyperglycemic clamp - Healthy Volunteers | Phase 1 | Completed | National Institute on Aging (NIA) | 45 | 2012-01-05 | 2026-10-13 |
| Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis Sildenafil, Placebo, Hyperglycemic clamp - Impaired Glucose Tolerance | Phase 4 | Terminated | Vanderbilt University | 78 | 2011-08-01 | 2017-04-17 |
| The Reduced Insulinotropic Effect of a Continuous Infusion Relative to a Bolus Injection of GIP GIP Bolus, GIP Clamp, Oral glucose tolerance test (OGTT) - Type 2 Diabetes | Phase 1 | Completed | Diabeteszentrum Bad Lauterberg im Harz | 30 | 2004-05-01 | 2016-02-04 |
Insulin Resistance (5) · Diabetes Mellitus, Type 2 (3) · Glucose Intolerance (3) · Diabetes Mellitus (2) · Obesity (2) · Diabetes Mellitus, Type 1 (1) · Fatty Liver (1) · Fibrous Dysplasia of Bone (1) · Fibrous Dysplasia, Polyostotic (1) · Hyperglycemia (1) · Hyperinsulinism (1) · Metabolic Diseases (1) · Overweight (1) · Pediatric Obesity (1)
Yale University (2) · Adrian Vella (1) · Columbia University (1) · Diabeteszentrum Bad Lauterberg im Harz (1) · Massachusetts General Hospital (1) · National Institute on Aging (NIA) (1) · Nemours Children's Clinic (1) · Oslo University Hospital (1) · University of California, San Diego (1) · VA Office of Research and Development (1) · Vanderbilt University (1)
United States (10) · Norway (1)
Adrian Vella (1) · Cemre Robinson, MD (1) · Chee W Chia, M.D. (1) · David D'Alessio, MD (1) · Joshua R Cook, MD, PhD (1) · Lydia Snyder, MD (1) · Margaret Lippincott (1) · Michael A. Nauck, Prof. (1) · Nancy J Brown, MD (1) · Robert Thomas, MD, PhD (1) · Sonia Caprio, MD (1)
K23DK140614 (1), R01DK111038 (1)