6 recruiting, 4 active not recruiting, 3 completed, 2 not yet recruiting. 15 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Recruiting 6, Active not recruiting 4, Completed 3, Not yet recruiting 2 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
Follow Hydroxydaunomycin: new trials by email Literature Review of Hydroxydaunomycin trials Research Report on Hydroxydaunomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk Wall Biospecimen Collection, Computed Tomography, Doxorubicin - Resectable Liposarcoma, Resectable Soft Tissue Sarcoma | Phase 3 | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 228 | 2026-12-01 | 2026-09-16 |
| Testing the Addition of a New Anti-Cancer Drug, Glofitamab to Usual Chemotherapy for Burkitt and Double Hit Lymphoma Biospecimen Collection, Bone Marrow Biopsy, Carboplatin - Recurrent Burkitt Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements | Phase 2 / Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 271 | 2026-10-30 | 2026-08-19 |
| A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) Bone Scan, Carboplatin, Computed Tomography - Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor | Phase 3 | Recruiting | Children's Oncology Group | 1656 | 2025-04-15 | 2026-08-25 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
| Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas Biospecimen Collection, Diagnostic Imaging Testing, Doxorubicin - Metastatic Dedifferentiated Liposarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 365 | 2024-09-11 | 2026-11-06 |
| Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Ganglioneuroblastoma, Nodular, Neuroblastoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 478 | 2024-04-19 | 2026-10-30 |
| Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer Biospecimen Collection, Cyclophosphamide, Doxorubicin - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 3680 | 2023-11-27 | 2026-11-06 |
| Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer Biospecimen Collection, Carboplatin, Cyclophosphamide - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 3 | Recruiting | SWOG Cancer Research Network | 2400 | 2023-09-15 | 2025-11-05 |
| Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery Biospecimen Collection, Carboplatin, Cisplatin - Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm | Phase 3 | Active not recruiting | Children's Oncology Group | 537 | 2018-05-24 | 2026-09-14 |
| Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Calaspargase Pegol, Cyclophosphamide - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 352 | 2017-08-08 | 2026-10-05 |
| Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Cyclophosphamide, Doxorubicin, Doxorubicin Hydrochloride - Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 312 | 2014-12-12 | 2026-10-22 |
| Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Bortezomib, Cyclophosphamide, Cytarabine - Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 847 | 2014-10-04 | 2026-10-21 |
| Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Doxorubicin, Doxorubicin Hydrochloride, Ifosfamide - Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma | Phase 2 / Phase 3 | Completed | National Cancer Institute (NCI) | 140 | 2014-08-12 | 2026-06-17 |
| Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Cyclophosphamide, Docetaxel, Doxorubicin - HER2/Neu Positive, Progesterone Receptor Positive | Phase 3 | Completed | National Cancer Institute (NCI) | 3270 | 2011-02-08 | 2025-07-14 |
| Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma Doxorubicin, Bleomycin, Vinblastine - Lymphoma | Phase 3 | Completed | Eastern Cooperative Oncology Group | 854 | 1999-06-17 | 2023-06-29 |
Burkitt Lymphoma (2) · Histiocytoma, Malignant Fibrous (2) · Liposarcoma (2) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (2) · Breast Neoplasms (1) · Chondrosarcoma, Extraskeletal Myxoid (1) · Chondrosarcoma, Mesenchymal (1) · Dermatofibrosarcoma (1) · Fibrolamellar hepatocellular carcinoma (1) · Fibrosarcoma (1) · Ganglioneuroblastoma (1) · Granuloma, Plasma Cell (1) · Hepatoblastoma (1) · Histiocytoma, Angiomatoid Fibrous (1) · Hodgkin Disease (1)
National Cancer Institute (NCI) (8) · Children's Oncology Group (4) · Eastern Cooperative Oncology Group (1) · Ohio State University Comprehensive Cancer Center (1) · SWOG Cancer Research Network (1)
United States (14) · Canada (11) · Puerto Rico (9) · Australia (5) · New Zealand (5) · Saudi Arabia (2) · Austria (1) · Belgium (1) · Chile (1) · Czechia (1) · Finland (1) · France (1) · Germany (1) · Hong Kong (1) · Ireland (1)
Aaron R Weiss (1) · Andrea Biondi (1) · David A Liebner (1) · David T Teachey (1) · Elizabeth A Mullen (1) · Erin F Cobain (1) · Gregory M Tiao (1) · Kris Ann P Schultz (1) · Kristie A Blum (1) · Lewis B Silverman (1) · Louis Fehrenbacher (1) · Priyanka Sharma (1) · Sandra J. Horning, MD (1) · Sara M Federico (1) · Seth M Pollack (1)
PMID 23182987, PMID 23356491, PMID 23386127, PMID 25897153, PMID 31821109, PMID 32702309, PMID 32827353, PMID 34515544, PMID 35271306, PMID 36603187, PMID 36669140, PMID 37523624, PMID 38457359, PMID 41213254, PMID 42208702
U10CA180886 (8), U10CA098543 (3), U10CA180888 (2), 2017 (1), U10CA012027 (1), U10CA021115 (1), U10CA180820 (1), U10CA180821 (1), U10CA180830 (1), U10CA180868 (1)