23 completed, 20 unknown, 5 withdrawn, 4 recruiting. 60 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 60 | Completed 23, Unknown 20, Withdrawn 5, Recruiting 4, Terminated 4, Not yet recruiting 2, Active not recruiting 1, Suspended 1 |
Follow Hydroxychloroquine: new trials by email Literature Review of Hydroxychloroquine trials Research Report on Hydroxychloroquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| Utilization of a Microdevice for Psoriasis and Atopic Dermatitis In situ cutaneous microdevice, Triamcinolone, 5-Fluorouracil - Psoriasis, Atopic Dermatitis | Phase 4 | Not yet recruiting | University of California, San Francisco | 10 | 2026-08-01 | 2026-06-03 |
| Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy? Oral prednisolone and SoC, Gut-directed budesonide and SoC, Mycophenolate mofetil (MMF) and SoC - IgA Nephropathy, Renal Insufficiency, Chronic | Phase 4 | Recruiting | Christian Medical College, Vellore, India | 585 | 2025-02-15 | 2025-07-14 |
| Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine-pyrimethamine-amodiaquine - Malaria,Falciparum, Anemia in Children | Phase 4 | Completed | Liverpool School of Tropical Medicine | 788 | 2024-10-14 | 2026-07-30 |
| Hydroxychloroquine as a Steroid-sparing Agent in Extrapulmonary Sarcoidosis Hydroxychloroquine, Placebo - Sarcoidosis, Pulmonary | Phase 4 | Recruiting | Hospices Civils de Lyon | 140 | 2024-07-30 | 2026-09-17 |
| Comparing Chemoprevention Drugs for School-based Malaria Control Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine pyrimethamine - Malaria,Falciparum, Anemia in Children | Phase 4 | Completed | University of Maryland, Baltimore | 646 | 2023-02-13 | 2023-08-07 |
| Multi-omics Studies on the Efficacy of Telitacicept in Chinese SLE Patients Telitacicept, Hydroxychloroquine, Prednisone - Systemic Lupus Erythematosus | Phase 4 | Unknown | Fen Li | 30 | 2022-12-31 | 2024-01-17 |
| Hydroxychloroquine in Mild Graves' Orbitopathy Hydroxychloroquine - Graves Ophthalmopathy | Phase 4 | Active not recruiting | National Taiwan University Hospital | 108 | 2022-03-21 | 2026-11-02 |
| The Efficacy and Safety of Iguratimod (IGU) in the Treatment of Primary Sjögren's Syndrome Iguratimod Tablets, Hydroxychloroquine Sulfate Tablets - Primary Sjögren's Syndrome | Phase 4 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 78 | 2022-01-14 | 2024-10-16 |
| The Clinical Efficacy of Immunomodulators in RA Patients Iguratimod, Methotrexate, Adalimumab Injection - Arthritis, Rheumatoid | Phase 4 | Recruiting | Qilu Hospital of Shandong University | 400 | 2021-12-22 | 2022-11-29 |
| Hydroxychloroquine in ANCA Vasculitis Evaluation Hydroxychloroquine, Placebo - ANCA Associated Vasculitis, Microscopic Polyangiitis | Phase 4 | Terminated | Guy's and St Thomas' NHS Foundation Trust | 43 | 2020-12-17 | 2026-04-29 |
| Ivermectin Role in Covid-19 Clinical Trial ivermectin, hydroxychloroquine, Placebo - Covid19 | Phase 4 | Completed | Elaraby Hospital | 300 | 2020-12-06 | 2021-02-09 |
| A Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Spontaneous Abortion With Antiphospholipid Syndrome Hydroxychloroquine Sulfate Tablets - Antiphospholipid Syndrome, Recurrent Miscarriage | Phase 4 | Unknown | Shanghai First Maternity and Infant Hospital | 384 | 2020-12-01 | 2020-11-10 |
| Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 Doxycycline Tablets, Rivaroxaban 15Mg Tab, Hydroxychloroquine and Azithromycin - COVID-19 | Phase 4 | Unknown | Yaounde Central Hospital | 200 | 2020-10-05 | 2021-01-20 |
| Hydroxychloroquine in SARS-CoV-2 (COVID-19) Pneumonia Trial Hydroxychloroquine - SARS-CoV-2 Pneumonia, COVID-19 | Phase 4 | Withdrawn | Kootenai Health | 2020-10-01 | 2021-02-05 | |
| Comparative Therapeutic Efficacy and Safety of Different Antiviral and Anti Inflammatory Drugs in COVID-19 Patients. Remdesivir, Hydroxychloroquine, Tocilizumab - Covid19, Pneumonia | Phase 4 | Unknown | October 6 University | 150 | 2020-10-01 | 2021-03-17 |
| Rapid Development and Implementation of a Remote ECG-monitored Prospective Randomized Clinical Trial During a Pandemic: Hydroxychloroquine Prophylaxis in COVID-19 Household Contacts Hydroxychloroquine - Covid19, Hydroxychloroquine | Phase 4 | Completed | Bryn Mawr Hospital | 54 | 2020-05-27 | 2020-12-03 |
| Randomized Placebo-controlled Trial of Hydroxychloroquine in Outpatient Cases With Coronavirus Disease 2019 (COVID-19) Hydroxychloroquine, Placebo - COVID-19 | Phase 4 | Completed | Hospital Alemão Oswaldo Cruz | 1372 | 2020-05-12 | 2022-03-07 |
| Hydroxychloroquine Use in Hospitalized Patients With COVID-19: Impact on Progression to Severe or Critical Disease Hydroxychloroquine, Placebo - COVID-19 | Phase 4 | Unknown | WellStar Health System | 700 | 2020-05-07 | 2020-06-16 |
| Assessment of Efficacy and Safety of HCQ and Antibiotics Administrated to Patients COVID19(+) Hydroxychloroquine, Azithromycin - Patients With COVID19 | Phase 4 | Withdrawn | Abderrahmane Mami Hospital | 2020-05-05 | 2020-08-28 |
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COVID-19 (17) · Arthritis, Rheumatoid (12) · Coronavirus Infections (5) · Glomerulonephritis, IGA (3) · Cardiovascular Diseases (2) · Coronary Artery Disease (2) · Glomerulonephritis (2) · Lupus Erythematosus, Systemic (2) · Malaria, Falciparum (2) · Obesity (2) · Pneumonia (2) · Spondylitis, Ankylosing (2) · Abortion, Habitual (1) · Acute Coronary Syndrome (1) · Alopecia Areata (1)
Shahid Beheshti University of Medical Sciences (4) · Nanfang Hospital, Southern Medical University (2) · Qilu Hospital of Shandong University (2) · Radboud University Medical Center (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of Leeds (2) · Abderrahmane Mami Hospital (1) · Assiut University (1) · Brigham and Women's Hospital (1) · Bryn Mawr Hospital (1) · Christian Medical College, Vellore, India (1) · Duke University (1) · Elaraby Hospital (1) · Fen Li (1) · First Affiliated Hospital Xi'an Jiaotong University (1)
United States (12) · China (11) · Iran (4) · Brazil (3) · Egypt (3) · United Kingdom (3) · Finland (2) · France (2) · India (2) · Malawi (2) · Mexico (2) · Netherlands (2) · Argentina (1) · Cameroon (1) · Chile (1)
Seyed Sina Naghibi Irvani, MD, MPH, MBA (4) · Ilad Alavi Darazam, MD (2) · Jan Tack (2) · Mehran Lack, MD (2) · Minoosh Shabani, MD (2) · Mohammad Fathi, MD (2) · Mohammadreza Haji Esmaelie, MD (2) · Nader Markazi, MD (2) · Nasser Malekpour Alamdari, MD (2) · Sanaz Zargar Balaye Jam, MD (2) · Sasan Tavana, MD (2) · Shervin Shokouhi, MD (2) · Avni Thakore, MD (1) · Bart-Jan Kullberg, Prof., M.D. (1)
PMID 10649166, PMID 21417950, PMID 22508468, PMID 22730343, PMID 22753402, PMID 23908187, PMID 24254965, PMID 24356474, PMID 24907147, PMID 25274892, PMID 25617818, PMID 26197707, PMID 26421409, PMID 26429521, PMID 26606398, PMID 26847108, PMID 27006728, PMID 27028911, PMID 27188329, PMID 27483410, PMID 28376912, PMID 30295425, PMID 30796143, PMID 31197255, PMID 31590634, PMID 31732558, PMID 31849542, PMID 31996367, PMID 32503662, PMID 32513231, PMID 33082342, PMID 33486596, PMID 34031759, PMID 34037911, PMID 34263700, PMID 34273635, PMID 34493311, PMID 34496979, PMID 34535165, PMID 34764044, PMID 35262569, PMID 35378952, PMID 35788169, PMID 36450449, PMID 37024906, PMID 37448694, PMID 37591523, PMID 38299639, PMID 38487037, PMID 38915065
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