6 completed, 2 terminated, 1 active not recruiting, 1 recruiting. 7 Phase 1, 4 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 3, Terminated 2, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors Anti-CD40 Agonist Monoclonal Antibody CDX-1140, Poly ICLC, Radiation Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 | Active not recruiting | University of Southern California | 14 | 2023-01-09 | 2026-06-18 |
| CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer PLD Chemotherapy, CDX-1140, CDX-301 - HER2-negative Breast Cancer, Metastatic Breast Cancer | Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 30 | 2022-04-20 | 2026-06-17 |
| FLT3 Ligand, CD40 Agonist Antibody, and Stereotactic Radiotherapy FLT3 Ligand (CDX-301), anti-CD40 antibody (CDX-1140), SBRT - Non Small Cell Lung Cancer, Lung Cancer | Phase 1 / Phase 2 | Terminated | Albert Einstein College of Medicine | 5 | 2021-01-01 | 2024-02-28 |
| A Vaccine (CDX-1401) With or Without a Biologic Drug (CDX-301) for the Treatment of Patients With Stage IIB-IV Melanoma DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Recombinant Flt3 Ligand - Cutaneous Melanoma, Melanoma | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2014-04-09 | 2021-11-16 |
| Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer recombinant CD40-ligand, recombinant flt3 ligand - Kidney Cancer, Melanoma (Skin) | Phase 1 | Completed | National Cancer Institute (NCI) | 2001-03-01 | 2015-04-30 | |
| flt3L in Treating Patients With Acute Myeloid Leukemia recombinant flt3 ligand - Leukemia | Phase 3 | Completed | Eastern Cooperative Oncology Group | 2000-07-01 | 2013-06-24 | |
| Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer filgrastim, recombinant flt3 ligand, recombinant human thrombopoietin - Breast Cancer, Leukemia | Phase 1 / Phase 2 | Completed | Northwestern University | 1999-11-01 | 2012-06-06 | |
| Peripheral Stem Cell Transplantation to Prevent Neutropenia in Patients Receiving Chemotherapy for Relapsed or Refractory Non-Hodgkin's Lymphoma epoetin alfa, filgrastim, recombinant flt3 ligand - Lymphoma, Neutropenia | Phase 1 | Terminated | Northwestern University | 3 | 1999-09-01 | 2012-06-01 |
| Flt3L in Treating Patients With Metastatic Colorectal Cancer recombinant flt3 ligand - Colorectal Cancer, Metastatic Cancer | Phase 1 | Completed | Duke University | 1998-06-01 | 2013-03-05 | |
| flt3L With or Without Vaccine Therapy in Treating Patients With Metastatic Melanoma or Renal Cell Cancer flt3 ligand, gp100 antigen, MART-1 antigen - Stage IV Melanoma, Stage IV Renal Cell Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 1998-02-01 | 2024-03-04 |
Melanoma (4) · Breast Neoplasms (3) · Burkitt Lymphoma (2) · Carcinoma, Renal Cell (2) · Leukemia (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Lymphoma (2) · Lymphoma, B-Cell, Marginal Zone (2) · Lymphoma, Follicular (2) · Lymphoma, Large B-Cell, Diffuse (2) · Lymphoma, Large-Cell, Immunoblastic (2) · Lymphoma, Mantle-Cell (2) · Lymphoma, Non-Hodgkin (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Bone Neoplasms (1)
National Cancer Institute (NCI) (3) · Northwestern University (2) · Albert Einstein College of Medicine (1) · Duke University (1) · Eastern Cooperative Oncology Group (1) · University of Southern California (1) · University of Texas Southwestern Medical Center (1)
United States (10)
Jane N. Winter, MD (2) · Fumito Ito, MD (1) · Jacob M. Rowe, MD (1) · John E. Godwin, MD, MS (1) · Michael A. Morse, MD (1) · Nina Bhardwaj (1) · Patrick Hwu (1) · Patrick Hwu, MD (1) · Richard A. Larson, MD (1) · Sangeetha Reddy (1)
K08CA267189 (1), P30CA015704 (1), U01CA154967 (1)