10 completed, 2 recruiting, 1 active not recruiting, 1 unknown. 7 Phase 2, 5 Phase 1, 3 Not applicable, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 3, Recruiting 2, Active not recruiting 1, Unknown 1 |
| Phase 1 | 5 | Completed 4, Unknown 1 |
| Not applicable | 3 | Completed 3 |
| Early Phase 1 | 1 | Completed 1 |
Follow Equol: new trials by email Literature Review of Equol trials Research Report on Equol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Equol and Vascular Function in Women With Chronic Kidney Disease Equol, Placebo - Chronic Kidney Disease (Stage 3-4), Vascular Function | Phase 2 | Recruiting | University of Colorado, Denver | 74 | 2026-02-19 | 2026-06-02 |
| Genistein, Equol, Cognitive Function and Mood: Acute. (GECFAMa) Genistein, Equol, Maltodextrin (Placebo) - Cognition, Mood | Not applicable | Completed | University of Reading | 53 | 2024-11-14 | 2026-08-07 |
| Genistein, Equol, Cognitive Function and Mood: Twelve-week. (GECFAMc) Equol, Genistein, Maltodextrin - Cognition, Mood | Not applicable | Completed | University of Reading | 51 | 2024-11-01 | 2026-08-03 |
| Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers S-equol, Placebo - Arterial Stiffness, White Matter Lesions | Phase 2 | Active not recruiting | Akira Sekikawa | 369 | 2023-06-29 | 2026-08-20 |
| Acute Equol Supplementation and Vascular Function in Women With and Without CKD S-equol, Placebo - Chronic Kidney Diseases, Vascular Function | Phase 2 | Recruiting | University of Colorado, Denver | 38 | 2023-03-07 | 2025-09-30 |
| A Nutritional Supplement on Vasomotor Symptoms in Women Placebo, S-equol - Menopause | Not applicable | Completed | Pharmavite LLC | 118 | 2019-03-27 | 2024-04-04 |
| S-Equol in Alzheimer's Disease 2 Trial S-equol and Placebo, Placebo and S-equol - Alzheimer Disease | Phase 1 / Phase 2 | Completed | Russell Swerdlow | 40 | 2017-05-05 | 2024-07-25 |
| S-equol in Women With Triple Negative Breast Cancer S-equol - Breast Cancer | Early Phase 1 | Completed | The University of Texas Health Science Center at San Antonio | 39 | 2015-04-15 | 2020-07-22 |
| S-Equol in Alzheimer's Disease (SEAD) Trial S -Equol, Placebo - Alzheimer's Disease | Phase 1 | Completed | Russell Swerdlow, MD | 15 | 2014-07-01 | 2016-08-16 |
| A Novel Combination Oral Agent to Treat Acne Vulgaris Doxycycline and S-equol, Doxycycline - ACNE VULGARIS | Phase 1 / Phase 2 | Unknown | Nexgen Dermatologics, Inc. | 60 | 2010-11-01 | 2011-02-23 |
| Efficacy and Safety of S-equol on Vasomotor Symptoms in Menopausal Patients Placebo, S-equol - Menopause | Phase 2 | Completed | Ausio Pharmaceuticals, LLC | 169 | 2010-06-01 | 2014-04-08 |
| Efficacy and Safety of S-Equol on Men With Benign Prostatic Hyperplasia S-equol, Placebo - Benign Prostatic Hyperplasia | Phase 2 | Completed | Ausio Pharmaceuticals, LLC | 116 | 2009-06-01 | 2017-05-19 |
| Multi-Dose Safety and Pharmacokinetic Study of S-Equol in Healthy Volunteers S-equol, Placebo - Healthy | Phase 1 | Completed | Ausio Pharmaceuticals, LLC | 41 | 2008-12-01 | 2012-07-12 |
| Safety and Pharmacokinetic Study of S-Equol in Healthy Volunteers S-equol, Placebo - Healthy | Phase 1 | Completed | Ausio Pharmaceuticals, LLC | 60 | 2008-09-01 | 2012-01-20 |
Alzheimer Disease (3) · Renal Insufficiency, Chronic (2) · Acne Vulgaris (1) · Breast Neoplasms (1) · Bronchiolitis Obliterans Syndrome (1) · Cognitive Dysfunction (1) · Dementia (1) · Prostatic Hyperplasia (1)
Ausio Pharmaceuticals, LLC (4) · University of Colorado, Denver (2) · University of Reading (2) · Akira Sekikawa (1) · Nexgen Dermatologics, Inc. (1) · Pharmavite LLC (1) · Russell Swerdlow (1) · Russell Swerdlow, MD (1) · The University of Texas Health Science Center at San Antonio (1)
United States (12) · United Kingdom (2) · Australia (1) · India (1)
Claire Williams, PhD (2) · Daniel Lamport, PhD (2) · Luke R Till, MSc (2) · Akira Sekikawa, MD, PhD, PhD (1) · Donald Bergner, MD (1) · Elizabeth Bianchi, MD (1) · Joshua M Berlin, MD (1) · Kate Lathrop, MD (1) · Michael A Thomas, MD (1) · Russell H Swerdlow, MD (1) · Russell Swerdlow, MD (1)
R01AG074971 (1)