8 terminated. 8 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Terminated 8 |
| Phase 2 | 2 | Terminated 2 |
Follow entinostat: new trials by email Literature Review of entinostat trials Research Report on entinostat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT) Brachyury-TRICOM, Entinostat, M7824 - Breast Cancer, Triple Negative Breast Cancer | Phase 1 | Terminated | National Cancer Institute (NCI) | 1 | 2021-05-04 | 2022-01-11 |
| Olaparib and Entinostat in Patients With Recurrent, Platinum-Refractory, Resistant Ovarian, Primary Peritoneal, Fallopian Tube Cancers Entinostat, Olaparib - Fallopian Tube Cancer, Fallopian Tube Carcinosarcoma | Phase 1 | Terminated | Vanderbilt-Ingram Cancer Center | 3 | 2020-10-01 | 2022-04-04 |
| Combination of Entinostat and Enzalutamide in Advanced Prostate Cancer Entinostat, Enzalutamide - Prostate Adenocarcinoma | Phase 1 | Terminated | George Washington University | 6 | 2019-05-01 | 2021-08-02 |
| Atezolizumab in Combination With Entinostat and Bevacizumab in Patients With Advanced Renal Cell Carcinoma Atezolizumab, Bevacizumab, Entinostat - Metastatic Cancer, Renal Cancer | Phase 1 / Phase 2 | Terminated | Roberto Pili | 31 | 2017-06-29 | 2025-03-20 |
| Azacitidine and Entinostat in Treating Patients With Newly Diagnosed Stage IA-IIIA Non-Small Lung Cancer Undergoing Surgery Azacitidine, Entinostat, Laboratory Biomarker Analysis - Stage IA Non-Small Cell Lung Carcinoma, Stage IB Non-Small Cell Lung Carcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 40 | 2013-06-01 | 2016-11-18 |
| Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia entinostat, imatinib mesylate, laboratory biomarker analysis - Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 2 | 2010-10-01 | 2017-08-08 |
| Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia entinostat, sorafenib tosylate, pharmacological study - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 44 | 2010-06-01 | 2013-09-19 |
| A Phase I, Multicenter, Open Label Study on the Effects of SNDX-275 on Expression of Biomarkers in Subjects With Newly Diagnosed Breast Cancer SNDX-275 - Breast Cancer | Phase 1 | Terminated | Syndax Pharmaceuticals | 1 | 2008-06-01 | 2022-06-06 |
Breast Neoplasms (2) · Blast Crisis (1) · Carcinoma, Non-Small-Cell Lung (1) · Congenital Abnormalities (1) · Endometrial Neoplasms (1) · Fallopian Tube Neoplasms (1) · Kidney Neoplasms (1) · Leukemia, Basophilic, Acute (1) · Leukemia, Eosinophilic, Acute (1) · Leukemia, Erythroblastic, Acute (1) · Leukemia, Megakaryoblastic, Acute (1) · Leukemia, Monocytic, Acute (1) · Leukemia, Myeloid, Acute (1) · Leukemia, Myelomonocytic, Acute (1) · Neoplasm Metastasis (1)
National Cancer Institute (NCI) (4) · George Washington University (1) · Roberto Pili (1) · Syndax Pharmaceuticals (1) · Vanderbilt-Ingram Cancer Center (1)
United States (8)
Alex Adjei (1) · Andrew Baildam, MD (1) · Fatima H Karzai, M.D. (1) · Jianquig Lin, MD (1) · Marta Crispens, MD (1) · Monet Bowling, MD (1) · Montaser Shaheen (1) · Nabil Adra, MD (1) · Patrick Brown (1)
P30CA118100 (1), R21CA161561 (1), U01CA070095 (1)