7 completed, 5 terminated, 1 withdrawn. 5 Phase 1, 4 Phase 2, 3 Not applicable, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Terminated 3, Completed 2 |
| Phase 2 | 4 | Completed 4 |
| Not applicable | 3 | Terminated 2, Completed 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
Follow EF5: new trials by email Literature Review of EF5 trials Research Report on EF5
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Imaging and Biomarkers of Hypoxia in Solid Tumors PET Scan, EF5, Carbogen - Neoplasms | Phase 1 | Terminated | Stanford University | 28 | 2010-12-01 | 2017-11-06 |
| Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers Dichloroacetate, EF5 - Head and Neck Cancer, Head and Neck Cancers | Phase 1 | Completed | Daniel T. Chang | 17 | 2010-08-01 | 2022-06-16 |
| To Evaluate the Characteristics of a Breast Cancer EF5, Partial or Total Mastectomy - Breast Cancer | Early Phase 1 | Withdrawn | Mark Dewhirst | 2010-01-01 | 2012-12-17 | |
| Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors EF5, conventional surgery, positron emission tomography - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 46 | 2005-06-01 | 2013-01-16 |
| EF5 in Finding Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Cervical, Endometrial, or Ovarian Epithelial Cancer EF5 - Primary Peritoneal Cavity Cancer, Stage I Endometrial Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2005-02-01 | 2013-01-16 |
| EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer EF5, motexafin lutetium, pharmacological study - Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix | Not applicable | Terminated | National Cancer Institute (NCI) | 30 | 2004-05-01 | 2013-01-16 |
| EF5 to Detect Tumor Hypoxia in Patients With Stage IIB, Stage IIIB, or Stage IVA Cervical Cancer EF5, immunohistochemistry staining method, biopsy - Cervical Cancer | Not applicable | Completed | Gynecologic Oncology Group | 2003-06-01 | 2013-06-24 | |
| EF5 Compared With Other Methods of Detecting Oxygen Levels in Tumor Cells of Patients With Head and Neck Cancer EF5, bioluminescence, flow cytometry - Head and Neck Cancer | Phase 2 | Completed | David M. Brizel, MD | 8 | 2002-08-01 | 2014-07-25 |
| EF5 in Assessing Tumor Response to Anticancer Therapy in Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer EF5, flow cytometry, immunohistochemistry staining method - Lung Cancer | Phase 2 | Completed | Duke University | 60 | 2002-05-01 | 2015-05-01 |
| EF5 in Measuring Tumor Hypoxia in Patients With Stage I-III Non-Small Cell Lung Cancer EF5, Laboratory Biomarker Analysis, Therapeutic Conventional Surgery - Stage IA Non-Small Cell Lung Carcinoma, Stage IB Non-Small Cell Lung Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 28 | 2002-05-01 | 2015-04-13 |
| EF5 to Evaluate Tumor Hypoxia in Patients With High-Grade Soft Tissue Sarcoma or Mouth Cancer EF5, diagnostic laboratory biomarker analysis, pharmacological study - Stage I Adult Soft Tissue Sarcoma, Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity | Not applicable | Terminated | National Cancer Institute (NCI) | 120 | 2001-08-01 | 2013-01-16 |
| EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or High Grade Soft Tissue Sarcoma EF5, flow cytometry, fluorescent antibody technique - Breast Cancer, Cervical Cancer | Phase 1 | Terminated | University Health Network, Toronto | 1999-12-01 | 2018-02-22 | |
| EF5 in Treating Patients With Solid Tumors EF5, therapeutic conventional surgery, biopsy - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 50 | 1998-03-01 | 2013-01-16 |
Carcinoma, Non-Small-Cell Lung (3) · Head and Neck Neoplasms (3) · Sarcoma (3) · Uterine Cervical Neoplasms (3) · Breast Carcinoma In Situ (2) · Breast Neoplasms (2) · Carcinoma, Ovarian Epithelial (2) · Salivary Gland Neoplasms (2) · Appendiceal Neoplasms (1) · Astrocytoma (1) · Bile Duct Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Lobular (1) · Choroid Plexus Neoplasms (1)
National Cancer Institute (NCI) (6) · Daniel T. Chang (1) · David M. Brizel, MD (1) · Duke University (1) · Gynecologic Oncology Group (1) · Mark Dewhirst (1) · Stanford University (1) · University Health Network, Toronto (1)
United States (12) · Canada (1)
Stephen Michael Hahn (4) · Anthony Fyles, MD (1) · Christina Chu (1) · Daniel T Chang (1) · David M. Brizel, MD (1) · Gillian M. Thomas, BSc, MD, FRCPC, FRCR (Hon) (1) · Mark W Dewhirst, DVM, PhD (1) · Michael J. Kelley, MD (1) · Michael Kelley (1)
P01CA087971 (1), P30CA014236 (1), R01CA040355 (1), R01CA075285 (1), R21CA091565 (1), R21CA099346 (1)