10 completed, 6 recruiting, 2 not yet recruiting, 2 unknown. 7 Phase 3, 7 Phase 4, 2 Not applicable, 2 Phase 1, 2 Phase 2.
Follow amoxicillin-clavulanate: new trials by email Literature Review of amoxicillin-clavulanate trials Research Report on amoxicillin-clavulanate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE) Shared decision-making, amoxicillin-clavulanate, Appendectomy - Acute Appendicitis | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 560 | 2026-10-01 | 2026-10-05 |
| Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media) Amoxicillin, Amoxicillin-Clavulanate, Amoxicillin Placebo - Acute Otitis Media (AOM) | Phase 4 | Recruiting | Nader Shaikh | 1100 | 2026-10-01 | 2026-10-20 |
| Non-antibiotic Management in Acute Uncomplicated Diverticulitis Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole - Acute Uncomplicated Diverticulitis | Phase 4 | Withdrawn | Montefiore Medical Center | 2026-07-01 | 2026-08-31 | |
| Efficacy of an Empirical Treatment With Amoxicillin-clavulanate (AC) Compared to the Combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the Outpatient Care of Chemotherapy-induced Fever in Adult Haematology Patients. amoxicillin-clavulanate, Amoxicillin-clavulanate ciprofloxacin - C15.378 | Phase 3 | Not yet recruiting | Versailles Hospital | 1526 | 2026-03-01 | 2026-03-19 |
| Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination Ledaborbactam etzadroxil, Ceftibuten, Ceftibuten-ledaborbactam etzadroxil - Healthy Volunteer, Pharmacokinetics | Phase 1 | Recruiting | Basilea Pharmaceutica | 96 | 2025-01-07 | 2026-07-09 |
| Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP Ampicillin for Injection, Ceftriaxone for Injection, Amoxicillin - Community Acquired Pneumonia in Children | Phase 4 | Recruiting | Medical College of Wisconsin | 236 | 2024-08-22 | 2026-03-02 |
| Effect of Tebipenem on Normal Human Intestinal Microbiota TBPM-PI-HBr, amoxicillin-clavulanate - Healthy Volunteers | Phase 1 | Completed | Spero Therapeutics | 30 | 2020-02-10 | 2021-05-04 |
| A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months OP0201, Placebo, Amoxicillin-clavulanate - Acute Otitis Media | Phase 2 | Completed | Novus Therapeutics, Inc | 103 | 2019-02-21 | 2020-08-18 |
| Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults Sulopenem, Sulopenem-Etzadroxil/Probenecid, Ertapenem - Complicated Urinary Tract Infections | Phase 3 | Completed | Iterum Therapeutics, International Limited | 1395 | 2018-09-18 | 2020-12-29 |
| Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI) Ertapenem, Sulopenem-Etzadroxil/Probenecid, Ciprofloxacin - Intra Abdominal Infections | Phase 3 | Completed | Iterum Therapeutics, International Limited | 674 | 2018-09-18 | 2020-12-01 |
| Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis anti-tuberculosis drug - Tuberculosis | Recruiting | Beijing Children's Hospital | 800 | 2018-07-01 | 2018-08-15 | |
| Trial to Evaluate Beta-Lactam Antimicrobial Therapy of Community Acquired Pneumonia in Children Amoxicillin, Amoxicillin-clavulanate, Cefdinir - Pneumonia | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 385 | 2016-12-02 | 2021-02-03 |
| Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem - Pharmacokinetics, Amoxicillin-clavulanate | Not applicable | Recruiting | University Hospital, Ghent | 300 | 2016-08-19 | 2026-09-21 |
| Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam - Community-acquired Pneumonia, Influenza, COVID-19 | Phase 3 | Recruiting | UMC Utrecht | 20000 | 2016-04-11 | 2024-07-12 |
| Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? Amoxicillin-clavulanate, Placebo - Sinusitis, Respiratory Tract Infections | Phase 3 | Completed | Nader Shaikh | 515 | 2016-02-01 | 2023-06-29 |
| Diverticulitis: Antibiotics or Close Observation? Amoxicillin-clavulanate - Diverticulitis | Phase 4 | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 533 | 2010-05-01 | 2012-10-29 |
| Acute Otitis Media (AOM) Therapy Trial in Young Children amoxicillin-clavulanate, Placebo - Acute Otitis Media | Phase 4 | Completed | University of Pittsburgh | 291 | 2006-11-01 | 2016-12-05 |
| Amoxicillin Clavulanate in Treatment of Acute Otitis Media amoxicillin-clavulanate, Placebo - Acute Otitis Media | Phase 4 | Unknown | University of Turku | 320 | 2006-03-01 | 2009-02-11 |
| Do Antibiotics Prevent Anal Fistulae Formation? Amoxicillin-Clavulanate, Placebo - Anal Fistula | Not applicable | Completed | Ankara University | 151 | 2005-09-01 | 2009-11-16 |
| Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis Clarithromycin, Amoxicillin - Acute Bacterial Sinusitis (ABS) | Phase 3 | Completed | Abbott | 437 | 2003-05-01 | 2008-03-27 |
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Otitis Media (4) · Community-Acquired Pneumonia (2) · Pneumonia (2) · Respiratory Tract Infections (2) · Abscess (1) · Acute Disease (1) · Appendicitis (1) · COVID-19 (1) · Diverticulitis (1) · Diverticulitis, Colonic (1) · Febrile Neutropenia (1) · Influenza, Human (1) · Intraabdominal Infections (1) · Lung Diseases (1) · Lymphoma, Follicular (1)
Iterum Therapeutics, International Limited (2) · Nader Shaikh (2) · Abbott (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ankara University (1) · Assistance Publique - Hôpitaux de Paris (1) · Basilea Pharmaceutica (1) · Beijing Children's Hospital (1) · Medical College of Wisconsin (1) · Montefiore Medical Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Novus Therapeutics, Inc (1) · Spero Therapeutics (1) · UMC Utrecht (1) · University Hospital, Ghent (1)
United States (11) · Hungary (4) · Estonia (3) · Finland (3) · France (3) · Belgium (2) · Canada (2) · Georgia (2) · Italy (2) · Latvia (2) · Netherlands (2) · Poland (2) · Romania (2) · Spain (2) · Australia (1)
A-Dong Shen, Master (1) · Aino Ruohola, MD, PhD (1) · Alejandro Hoberman, MD (1) · Annick de Jaeger, MD (1) · Colin McArthur, Dr (1) · Derek Angus, Prof (1) · Ellen R Wald, MD (1) · James Taylor, MD (1) · John Marshall, Prof (1) · Kamal Hamed, MD (1) · Lennie Derde, MD (1) · Marc Bonten, Prof (1) · Marie A Boermeester, MD, PhD, MSc (1) · Matti Uhari, Professor (1)
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