9 completed, 3 unknown, 1 withdrawn. 5 Phase 2, 4 Not applicable, 3 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Unknown 2 |
| Not applicable | 4 | Completed 3, Unknown 1 |
| Phase 4 | 3 | Completed 2, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow Alphagan: new trials by email Literature Review of Alphagan trials Research Report on Alphagan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Brimonidine for Intraoperative Hemostasis Brimonidine Topical - Dermatochalasis of Eyelid, Ptosis, Eyelid | Phase 4 | Withdrawn | University of Louisville | 2022-05-26 | 2025-01-15 | |
| The Effect of Brimonidine Brimonidine, Tropicamide, Phenylephrine Ophthalmic Product - Intraocular Pressure | Phase 4 | Completed | Wake Forest University Health Sciences | 13 | 2019-07-20 | 2024-02-01 |
| The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients Alphagan, Phenylephrine, Tropicamide - Intraocular Pressure | Phase 1 | Completed | Wake Forest University Health Sciences | 5 | 2016-09-01 | 2018-08-09 |
| The Effect of Topical Treatment With Combigan Compared to Timolol and Brimonidine on Pupil Diameter Combigan (Combination of Brimonidine and Timolol), Timolol - Healthy | Phase 2 | Unknown | Carmel Medical Center | 25 | 2015-10-01 | 2015-10-14 |
| A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension Fixed-Combination Bimatoprost/Brimonidine, Bimatoprost Ophthalmic Solution 0.01%, Vehicle Ophthalmic Solution - Glaucoma, Ocular Hypertension | Phase 2 | Completed | Allergan | 112 | 2013-06-01 | 2015-01-26 |
| Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection Timolol, Brimonidine, Acetazolamide - Intraocular Pressure Change in Intravitreal Injection | Not applicable | Completed | Mashhad University of Medical Sciences | 70 | 2012-02-01 | 2014-05-16 |
| Effect of Alphagan and Xalatan Eye Drops on Corneal Temperature Brimonidine, Latanoprost, Placebo - Primary Vascular Dysregulation | Not applicable | Completed | University Hospital, Basel, Switzerland | 40 | 2011-06-01 | 2013-12-11 |
| Intraocular Pressure (IOP) Lowering Efficacy of Transdermal Brimonidine Therapy Brimonidine, Placebo Lotion - Glaucoma | Phase 2 | Unknown | Nanduri, Padma, M.D., FACS | 22 | 2011-04-01 | 2011-05-02 |
| Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs YAG laser peripheral iridotomy - Glaucoma, Narrow Angle | Not applicable | Unknown | Universidade Federal do Paraná | 50 | 2010-11-01 | 2011-08-16 |
| Transconjunctival Needling Revision Versus Medical Treatment Transconjunctival needling revision, Medical treatment - Primary Open Angle Glaucoma | Phase 2 | Completed | University of Sao Paulo General Hospital | 40 | 2010-05-01 | 2013-06-27 |
| Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma brimonidine 0.15% - Glaucoma | Not applicable | Completed | Massachusetts Eye and Ear Infirmary | 46 | 2010-03-01 | 2017-04-04 |
| Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab Acetazolamide, Brimonidine tartarate, Anterior chamber paracentesis - Age Related Macular Degeneration, Diabetic Retinopathy | Phase 2 | Completed | University of Sao Paulo | 56 | 2008-06-01 | 2009-03-19 |
| Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) Istalol and Optive, Alphagan - Ocular Hypertension, Open-Angle Glaucoma | Phase 4 | Completed | Bp Consulting, Inc | 40 | 2008-06-01 | 2008-12-04 |
Glaucoma (4) · Glaucoma, Open-Angle (2) · Ocular Hypertension (2) · Blepharoptosis (1) · Diabetic Retinopathy (1) · Ectropion (1) · Entropion (1) · Glaucoma, Angle-Closure (1) · Low Tension Glaucoma (1) · Macular Degeneration (1) · Mydriasis (1)
Wake Forest University Health Sciences (2) · Allergan (1) · Bp Consulting, Inc (1) · Carmel Medical Center (1) · Mashhad University of Medical Sciences (1) · Massachusetts Eye and Ear Infirmary (1) · Nanduri, Padma, M.D., FACS (1) · Universidade Federal do Paraná (1) · University Hospital, Basel, Switzerland (1) · University of Louisville (1) · University of Sao Paulo (1) · University of Sao Paulo General Hospital (1)
United States (7) · Brazil (2) · Iran (1) · Israel (1) · Switzerland (1)
Keith Walter, MD (2) · Bianka Y Katayama, MD (1) · Christopher Compton, MD (1) · Jason Bacharach, M.D (1) · Josef Flammer, MD (1) · Louis R Pasquale, MD (1) · Lucas Shiokawa, MD (1) · Marco A Bonini-Filho, MD (1) · Michael Boone, MD (1) · Nasser Shoeibi, M.D. (1) · Orna Geyer, MD (1) · Padma Nanduri, MD (1) · Remo Susanna Jr., MD (1) · Ricardo Suzuki, MD (1)