10 completed, 6 terminated, 3 active not recruiting. 19 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 10, Terminated 6, Active not recruiting 3 |
| Phase 2 | 5 | Completed 2, Terminated 2, Active not recruiting 1 |
Follow alovudine: new trials by email Literature Review of alovudine trials Research Report on alovudine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Androgen Deprivation, With or Without pTVG-AR, and With or Without T-Cell Checkpoint Blockade, in Patients With Newly Diagnosed, High-Risk Prostate Cancer Degarelix, pTVG-AR, Nivolumab - Prostate Cancer | Phase 1 / Phase 2 | Active not recruiting | University of Wisconsin, Madison | 57 | 2021-12-16 | 2026-09-30 |
| SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients Trabectedin 1 MG [Yondelis], Irinotecan, tumor biopsy - Ewing Sarcoma | Phase 1 / Phase 2 | Completed | Sarcoma Alliance for Research through Collaboration | 37 | 2021-01-05 | 2025-12-17 |
| [18F]Fluciclovine and [18F]FLT PET/CT Assessment of Primary High-Grade Brain Tumors [18F]FLT, [18F]Fluciclovine - Brain Tumor | Phase 1 / Phase 2 | Terminated | University of Utah | 10 | 2018-09-24 | 2024-12-27 |
| 18F-FLT PET Imaging in Patients With Advanced Melanoma fludeoxyglucose F 18, Positron emission tomography-computed tomography, 18F-fluorothymidine - Melanoma | Phase 1 | Terminated | Washington University School of Medicine | 4 | 2016-10-10 | 2019-07-17 |
| [18F]FLT PET/CT in Rb+ Metastatic Breast Cancer [18F]FLT, PET/CT, ribociclib - Breast Neoplasm, Metastatic Breast Cancer | Phase 1 | Active not recruiting | University of Pennsylvania | 20 | 2015-11-01 | 2026-10-07 |
| VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Docetaxel in Treating Patients With Solid Tumors VEGFR/PDGFR dual kinase inhibitor X-82, docetaxel, fluorine F 18 fluorothymidine - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Wisconsin, Madison | 14 | 2014-09-01 | 2019-11-18 |
| Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma temozolomide, 3'-deoxy-3'-[18F]fluorothymidine, pharmacological study - Brain and Central Nervous System Tumors | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 28 | 2012-05-31 | 2019-05-22 |
| Phase I Study of IMRT and Molecular-Image Guided Adaptive Radiation Therapy for Advanced HNSCC intensity-modulated radiation therapy, cisplatin, image-guided adaptive radiation therapy - Salivary Gland Squamous Cell Carcinoma, Stage II Salivary Gland Cancer | Phase 1 | Terminated | Virginia Commonwealth University | 3 | 2011-07-01 | 2016-10-31 |
| Veliparib and Carboplatin in Treating Patients With HER2-Negative Metastatic Breast Cancer Biospecimen Collection, Carboplatin, Computed Tomography - Recurrent Breast Carcinoma, Stage IIIB Breast Cancer AJCC v7 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 44 | 2010-11-22 | 2026-05-22 |
| Multi-Tracer PET Assessment of Primary Brain Tumors [18F]fluoro-2-deoxy-D-glucose (FDG), 3'-deoxy-3'-[18F]fluorothymidine (FLT), [15O]-H2O - Brain Tumors, Cancer | Phase 1 | Completed | University of Utah | 11 | 2010-11-12 | 2022-04-27 |
| Sunitinib Malate and Bevacizumab in Treating Patients With Kidney Cancer or Advanced Solid Malignancies sunitinib malate, bevacizumab, pharmacological study - Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 6 | 2010-10-01 | 2014-04-02 |
| FLT-PET in Predicting Response to Chemotherapy in Patients With Advanced Malignancies Fluorothymidine F-18, Laboratory Biomarker Analysis, Positron Emission Tomography - Malignant Neoplasm | Phase 1 | Completed | M.D. Anderson Cancer Center | 10 | 2009-04-09 | 2023-06-26 |
| A Study to Demonstrate the Safety and Preliminary Efficacy of 18F-FLT in Patients With Solid Tumours or Lymphoma 18F-FLT - Brain Cancer, Cancer | Phase 1 / Phase 2 | Terminated | AHS Cancer Control Alberta | 94 | 2009-03-20 | 2019-08-22 |
| A Pilot Study of 18F-FLT in Pediatric Patients With Central Nervous System (CNS) Tumors 18F-FLT, PET Imaging - Tumors of the Central Nervous System | Phase 1 | Terminated | Dana-Farber Cancer Institute | 2 | 2008-03-01 | 2021-10-20 |
| Phase I, Open Label, Single Center Safety Study of [F-18]FLT F-18 FLT - Brain Cancer | Phase 1 | Completed | Siemens Molecular Imaging | 11 | 2007-11-01 | 2008-07-03 |
| Sunitinib Malate in Treating Patients With Unresectable or Metastatic Kidney Cancer or Other Advanced Solid Tumors Computed Tomography, Fluorothymidine F-18, Laboratory Biomarker Analysis - Adult Solid Neoplasm, Clear Cell Renal Cell Carcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 25 | 2007-05-22 | 2017-10-10 |
| Gold Sodium Thiomalate in Treating Patients With Advanced Non-Small Cell Lung Cancer gold sodium thiomalate, gene expression analysis, fluorine F 18 fluorothymidine - Lung Cancer | Phase 1 | Completed | Mayo Clinic | 17 | 2007-01-25 | 2018-10-09 |
| A Study of Changes in FDG- and FLT-PET Imaging in Patients With Non-Small Cell Lung Cancer Following Treatment With Erlotinib 2-deoxy-2-[18F]fluoro-D-glucose (FDG), 3'-deoxy-3'-[18F]fluorothymidine (FLT), erlotinib HCl - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | Genentech, Inc. | 88 | 2006-12-01 | 2017-03-31 |
| Alvocidib in Treating Patients With Metastatic or Unresectable Refractory Solid Tumors or Hematologic Malignancies alvocidib, pharmacological study, fludeoxyglucose F 18 - Hematopoietic/Lymphoid Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | National Cancer Institute (NCI) | 100 | 2003-08-01 | 2013-12-16 |
Brain Neoplasms (5) · Neoplasms (3) · Breast Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Central Nervous System Neoplasms (2) · Astrocytoma (1) · Disease (1) · Ependymoma (1) · Glioblastoma (1) · Glioma (1) · Hematologic Neoplasms (1) · Lung Neoplasms (1) · Lymphoma (1) · Melanoma (1)
National Cancer Institute (NCI) (4) · University of Utah (2) · University of Wisconsin, Madison (2) · AHS Cancer Control Alberta (1) · Dana-Farber Cancer Institute (1) · Genentech, Inc. (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Sarcoma Alliance for Research through Collaboration (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Siemens Molecular Imaging (1) · University of Pennsylvania (1) · Virginia Commonwealth University (1) · Washington University School of Medicine (1)
United States (17) · Canada (1)
Glenn Liu (2) · Bernard Fine, M.D. (1) · Charles M Intenzo, MD (1) · Daniel Kadrmas, PhD (1) · David Mankoff, MD, PhD (1) · Douglas McNeel, MD (1) · Geoffrey Shapiro (1) · Howard Colman, MD,PhD (1) · Jeffrey Yap, PhD (1) · John Glod, MD/PhD (1) · John M Hoffman, MD (1) · Julian Molina, MD, PhD (1) · Justine Bruce, MD (1) · Kai C Johnson (1) · Mark Kieran, MD (1)
PMID 28371832, PMID 28570723, PMID 41781018, PMID 41991689
P30CA014520 (2), U01CA062491 (2), P30CA016058 (1), P30CA016059 (1), P50CA269011 (1), U01CA062490 (1), U01CA070095 (1), U01CA076576 (1), U01CA236220 (1), UM1CA186712 (1)