16 completed, 1 recruiting, 1 unknown, 1 withdrawn. 15 Not applicable, 2 Phase 3, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Completed 13, Unknown 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Hydroxytyrosol on NLR, MLR, and SOD in Hypertensive Pregnant Women Placebo, Hydroxytyrosol - Hypertension in Pregnancy | Not applicable | Completed | Dr Cipto Mangunkusumo General Hospital | 42 | 2025-07-10 | 2026-01-02 |
| The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy Placebo, Hydroxytyrosol - Hypertension in Pregnancy | Not applicable | Completed | Dr Cipto Mangunkusumo General Hospital | 52 | 2025-06-11 | 2026-08-26 |
| Evaluation of the Functionality of an Extract Rich in Phytosterols and Phytostanols on Parameters Related to the Lipid Profile of Individuals With Hypercholesterolemia, Mainly in the Levels of Total Cholesterol, LDL Cholesterol and Oxidized LDL Plant based extract rich in phytosterols and phytostanols resveratrol and hydroxytyrosol., Placebo - Cholesterol Lowering, LDL Level | Not applicable | Completed | Centro de Edafología y Biología Aplicada del Segura | 45 | 2025-01-14 | 2025-05-01 |
| Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer Hydroxytyrosol - Advanced or Metastatic CRC | Phase 1 | Recruiting | The Methodist Hospital Research Institute | 33 | 2024-12-04 | 2026-10-07 |
| Bioavailability of Hydroxytyrosol in Humans Co-administered With EPA Hydroxytyrosol acetate (HT-Ac), Hydroxytyrosol eicosapentanoate (HT-EPA), Oleacore® - Healthy, Young | Not applicable | Completed | National Research Council, Spain | 12 | 2024-11-18 | 2025-04-11 |
| Dietary Supplement on the Intestinal Microbiota in Patients with Colon Cancer Experimental Treatment, DCOOP Product, Hydroxytyrosol extract, Experimental Treatment,Indukern product, Curcumin and selenium extract, Control Treatment - Colon Cancer | Not applicable | Completed | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 75 | 2022-11-16 | 2025-02-12 |
| Dietary Strategy to Tackle Sarcopenia in Early Elderly Subjects (FOOP-Sarc) Refined olive oil (38.6 mg hydroxytyrosol and tyrosol/kg oil), Virgin olive oil rich in phenolic compounds (156 mg hydroxytyrosol and tyrosol/kg oil), Maltodextrin - Sarcopenia | Not applicable | Completed | University Rovira i Virgili | 39 | 2022-09-01 | 2025-12-22 |
| Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases hydroxytyrosol (HT) intake, hydroxytyrosol (HT) intake and withdraw - Mitochondrial Diseases | Not applicable | Completed | Hong Kong Children's Hospital | 10 | 2022-07-05 | 2024-11-06 |
| Hydroxytyrosol Caramel Treatment on Cardiovascular Risk Patients HT treatment, Placebo treatment - Cardiovascular Pathology | Not applicable | Completed | Universidad Católica San Antonio de Murcia | 26 | 2022-04-15 | 2024-03-20 |
| Innovative Biotechnological Production of Antioxidant Products Hydroxytyrosol/Essential oils - Oxidative Stress, Inflammation | Not applicable | Completed | University of Ioannina | 12 | 2022-02-10 | 2023-01-10 |
| Positive Effects of Daily Consumption of Bread Enriched With Hydroxytyrosol on the Results of a 12-week Dietary Intervention on Subjects With Type 2 Diabetes Mellitus and Overweight/ Obesity Wheat bread enriched with hydroxytyrosol, Wheat bread - Type 2 Diabetes Mellitus, Obesity | Not applicable | Completed | Harokopio University | 60 | 2021-05-24 | 2022-03-02 |
| Bioavailability of Hydroxytyrosol From Olive Watery Extract Supplements Oliphenolia® bitter, Oliphenolia®, La Vialla Extra Virgin Olive Oil containing 5 mg hydroxytyrosol - Biological Availability | Not applicable | Completed | Daacro | 13 | 2021-05-10 | 2021-07-14 |
| Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function Olivomed (capsules containing hydroxytyrosol), OlivomedSmart - Capsules containing - combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal (OC) - (OL:HT:OC 2:1:3), (5 mg HT bid). - Coronary Artery Disease | Not applicable | Unknown | University of Athens | 30 | 2020-12-01 | 2024-05-29 |
| Effects of Hydroxytyrosol Administration in Anthropometric Parameters in Overweight and Obese Women Hydroxytyrosol, Diet - Body Weight, Visceral Obesity | Not applicable | Completed | National and Kapodistrian University of Athens | 37 | 2017-10-30 | 2020-03-20 |
| Hydroxytyrosol and Vitamin E in Pediatric NASH Hydroxytyrosol plus Vitamin E, Placebo - NAFLD | Phase 3 | Completed | Bambino Gesù Hospital and Research Institute | 80 | 2017-04-01 | 2018-07-17 |
| Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects hydroxytyrosol, placebo - Healthy | Not applicable | Completed | IMDEA Food | 20 | 2014-10-01 | 2015-03-24 |
| Olive Oil for High Risk Breast Cancer Prevention in Women Hydroxytyrosol - Breast Cancer | Phase 2 / Phase 3 | Completed | The Methodist Hospital Research Institute | 51 | 2013-12-01 | 2023-10-10 |
| Olive Oil and Cardiovascular Health Hydroxytyrosol, the active ingredient in olive oil., Placebo, Nutrition counseling - Cardiovascular Disease, Endothelial Function | Not applicable | Withdrawn | Mayo Clinic | 2013-08-01 | 2015-06-03 | |
| Punicalagin and Hydroxytyrosol Mixture on Different Inflammatory Markers punicalagin and hydroxytyrosol mixture, Control supplement (maltodextrin) - Healthy | Phase 4 | Completed | Instituto de Investigación Hospital Universitario La Paz | 76 | 2013-04-01 | 2014-01-23 |
Body Weight (2) · Hypertension, Pregnancy-Induced (2) · Breast Neoplasms (1) · Cardiovascular Diseases (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 2 (1) · Inflammation (1) · Metabolic Diseases (1) · Mitochondrial Diseases (1) · Non-alcoholic Fatty Liver Disease (1) · Obesity (1) · Obesity, Abdominal (1) · Sarcopenia (1)
Dr Cipto Mangunkusumo General Hospital (2) · The Methodist Hospital Research Institute (2) · Bambino Gesù Hospital and Research Institute (1) · Centro de Edafología y Biología Aplicada del Segura (1) · Daacro (1) · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (1) · Harokopio University (1) · Hong Kong Children's Hospital (1) · IMDEA Food (1) · Instituto de Investigación Hospital Universitario La Paz (1) · Mayo Clinic (1) · National Research Council, Spain (1) · National and Kapodistrian University of Athens (1) · Universidad Católica San Antonio de Murcia (1) · University Rovira i Virgili (1)
Spain (7) · Greece (4) · United States (3) · Indonesia (2) · Germany (1) · Hong Kong (1) · Italy (1)
Abdullah Esmail, MD (1) · Amir Lerman, MD (1) · Cheuk Wing Fung (1) · Francesco Visioli, Prof (1) · Gabriel Olveira Fuster, MD, PhD. (1) · Ignatios Ikonomidis (1) · Jenny Chang, MD (1) · Juliane Hellhammer, PhD (1) · Nikolaos Tentolouris, MD,PhD (1) · Patra Vezyraki, PhD (1) · Rosa Maria Valls, Dr (1)
PMID 25836918, PMID 33060043, PMID 37017765, PMID 38794734, PMID 39882028, PMID 40184328, PMID 40619979, PMID 41787835