7 active not recruiting. 7 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Active not recruiting 7 |
| Phase 1 | 4 | Active not recruiting 4 |
Follow Unresectable Malignant Solid Neoplasm: new trials by email Literature Review of Unresectable Malignant Solid Neoplasm trials Research Report on Unresectable Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 33 | 2023-09-22 | 2026-08-24 |
| Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure, Biospecimen Collection - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 88 | 2022-11-14 | 2026-09-25 |
| Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 54 | 2020-07-17 | 2026-10-27 |
| Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies Avelumab, Biopsy Procedure, Biospecimen Collection - Locally Advanced Malignant Solid Neoplasm, Locally Advanced Unresectable Cholangiocarcinoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 103 | 2020-04-07 | 2026-10-02 |
| Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors Avelumab, Berzosertib - Metastatic Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 23 | 2020-03-17 | 2026-06-11 |
| Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 54 | 2019-12-14 | 2026-11-02 |
| Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 96 | 2014-03-26 | 2026-09-11 |
Neoplasm Metastasis (7) · Cholangiocarcinoma (1) · Gallbladder Neoplasms (1)
Neoplasms (7) · Neoplastic Processes (7) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Adenocarcinoma (1) · Biliary Tract Diseases (1) · Biliary Tract Neoplasms (1) · Carcinoma (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Gallbladder Diseases (1) · Neoplasms by Histologic Type (1) · Neoplasms by Site (1) · Neoplasms, Glandular and Epithelial (1)
Specimen Handling (6) · Biopsy (5) · Magnetic Resonance Spectroscopy (3) · X-Rays (2) · avelumab (2) · CTLA-4 Antigen (1) · Ipilimumab (1) · Nivolumab (1) · Paclitaxel (1) · Phantoms, Imaging (1) · Radiation (1) · Radiation Dose Hypofractionation (1) · Taxes (1) · berzosertib (1) · copanlisib (1)
National Cancer Institute (NCI) (6) · M.D. Anderson Cancer Center (1)
United States (7) · Canada (1) · Puerto Rico (1)
Timothy A Yap (3) · Funda Meric-Bernstam (1) · Kristen R Spencer (1) · Reva K Basho (1) · Ryan B Corcoran (1)
UM1CA186688 (3), P30CA006516 (1), P50CA127003 (1), U01CA062490 (1), U10CA180888 (1), UM1CA186644 (1), UM1CA186709 (1), UM1CA186716 (1)