124 completed, 32 unknown, 9 terminated, 6 active not recruiting. 142 Not applicable, 2 Phase 2, 2 Phase 4, 1 Phase 3.
Follow Treatment Refusal: new trials by email Literature Review of Treatment Refusal trials Research Report on Treatment Refusal
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Development and Evaluation of a Digital Educational Intervention to Improve Vaccine Confidence and Communication Among Registered Nurses: Protocol for a Randomized Controlled Trial (VaxNurse-RCT). Digital educational intervention - Vaccine Hesitancy, Vaccine Acceptance | Not applicable | Not yet recruiting | Universite du Quebec en Outaouais | 100 | 2027-01-01 | 2026-10-06 |
| Addressing COVID-19 Vaccine Hesitancy With Muliti-Level Interventions in Appalachia Health Communication, Health Communication + Structural - COVID-19, Vaccine Hesitancy | Not applicable | Withdrawn | Marc Kiviniemi | 2027-01-01 | 2026-11-06 | |
| Conversational AI for Adult Flu Vaccination Decisions Flu vaccination guide, Accident safety guide - Influenza, Human, Vaccine Hesitancy | Not applicable | Active not recruiting | Calypta Systems, Inc. | 220 | 2026-10-21 | 2026-11-04 |
| Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP) Intrahospital seasonal influenza vaccination offer, Standardized active influenza vaccination counseling, Standard of care discharge recommendation for ambulatory vaccination - Acute Coronary Syndrome, Heart Failure | Not applicable | Recruiting | Stephan Baldus | 482 | 2026-09-30 | 2026-10-13 |
| Patients' Refusal to Participate in Surgical Research: Prevalence, Attributed Factors, and How to Overcome Questionnaire - Participation Rate, Patient, Clinical Trials | Recruiting | Mansoura University | 372 | 2026-09-09 | 2026-09-30 | |
| Parents' Knowledge and Attitudes Towards Vaccinating Their Children questionnaire application - Vaccine Hesitancy | Not applicable | Not yet recruiting | Iuliu Hatieganu University of Medicine and Pharmacy | 200 | 2026-07-01 | 2026-06-29 |
| A Bio-Psycho-Social Medical Model-Based Study on Adolescent Female HPV Vaccination Behavior and Comprehensive Intervention the BPS-based comprehensive intervention - HPV, Vaccination Hesitancy | Not applicable | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 300 | 2026-04-30 | 2026-05-01 |
| Media Orientation to Improve Childhood Vaccine Uptake and Address Parent and Caregivers Vaccine-related Anxiety: A Pilot Study ASSURed awareness campaign to encourage childhood vaccine uptakE (ASSURE) intervention, Intervention as usual - Anxiety, Vaccination Hesitancy | Not applicable | Not yet recruiting | Teesside University | 74 | 2026-04-20 | 2026-04-03 |
| Effect of Primary Care Education on Parents' Health-Related Perceptions and Attitudes Structured Education Program - Vaccine Hesitancy, Health Education | Not applicable | Completed | Yuzuncu Yil University | 173 | 2026-01-20 | 2026-04-29 |
| Effects of Italian Law 219/2017 in Pediatric Intensive Care Units Questionnaire administration - Refusal of Treatment | Not yet recruiting | University of Padova | 172 | 2025-11-25 | 2025-11-28 | |
| Effects of Individual and Group Education on Mothers' Attitudes and Decisions About Childhood Vaccination Vaccination attitude - Childhood Immunization | Not applicable | Active not recruiting | Istanbul University - Cerrahpasa | 75 | 2025-11-15 | 2026-01-07 |
| THE EFFECTS OF HPV VACCİNATİON AND MESSAGE FRAMİNG Gain-Framed HPV Vaccination Message, Loss-Framed HPV Vaccination Message - Human Papillomavirus Infection, HPV Vaccination | Not applicable | Completed | Ankara Medipol University | 177 | 2025-10-16 | 2026-11-04 |
| Effectiveness of SMS Nudging to Increase Coverage of Influenza Vaccination Among the Elderly Norwegian SMS, Polish/Ukrainian SMS - Influenza | Not applicable | Completed | Norwegian Institute of Public Health | 1000000 | 2025-10-14 | 2026-11-05 |
| Facilitators and Barriers to Eptinezumab Administration in Thailand Eptinezumab, Sham (No Treatment) - Migraine, Treatment | Completed | Chulalongkorn University | 30 | 2025-08-25 | 2026-04-08 | |
| Predicting Vaccine Hesitancy Using Machine Learning Vaccine Refusal, Vaccine Hesitancy | Completed | University of Yalova | 461 | 2025-07-02 | 2026-07-14 | |
| Community-Led COVID-19 Testing Intervention to Address Mistrust Community-led discussion - COVID-19, Trust | Not applicable | Completed | Old Dominion University | 49 | 2025-07-01 | 2026-09-11 |
| Improving Vaccine Acceptance Through EHR Integrated Patient- and Provider-Facing Decision Support LetsTalkShots (patient-facing CDS), LetsTalkShots (provider-facing CDS), Appointment Reminder Message - Vaccine Hesitancy, Vaccine Refusal | Not applicable | Completed | Johns Hopkins Bloomberg School of Public Health | 3600 | 2025-06-11 | 2026-09-04 |
| PREVENT Pilot HPV - Related Cancers Trial PREVENT - HPV Vaccination, Uptake Vaccination | Not applicable | Completed | University of Utah | 335 | 2025-05-17 | 2026-06-05 |
| Thimble Mindfulness App and Recovery Patch Descriptions Thimble Application - Needle Fear, Vaccine Hesitancy | Not applicable | Withdrawn | Bianca Edison | 2025-04-01 | 2025-04-30 | |
| Active Health Education to Increase HPV Vaccine Coverage in Youth: A Stepped-wedge, Cluster, and Randomized Trial Active Students Education plus Teacher Training, Active Students Education, Basic Health Unit Active Orientation - Vaccine Refusal, Vaccine Hesitancy | Not applicable | Recruiting | Hospital Israelita Albert Einstein | 5000 | 2025-03-24 | 2025-11-18 |
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Vaccination Hesitancy (120) · Vaccination Refusal (64) · COVID-19 (60) · Communication (14) · Influenza, Human (12) · Patient Compliance (9) · Behavior (7) · Health Education (7) · Health Behavior (5) · Papillomavirus Infections (5) · Patient Acceptance of Health Care (5) · Bipolar Disorder (4) · Pneumonia (4) · Vaccine-Preventable Diseases (4)
Treatment Adherence and Compliance (186) · Health Behavior (183) · Behavior (181) · Vaccination Refusal (96) · Infections (77) · Virus Diseases (76) · RNA Virus Infections (71) · Respiratory Tract Diseases (67) · Respiratory Tract Infections (65) · Coronaviridae Infections (61) · Nidovirales Infections (61) · Lung Diseases (60) · Pneumonia, Viral (59) · Coronavirus Infections (58)
Surveys and Questionnaires (9) · Methods (6) · Motivational Interviewing (5) · Educational Status (2) · pegaspargase (2) · COVID-19 Vaccines (1) · Censuses (1) · Cognitive Restructuring (1) · Communication Devices for People with Disabilities (1) · Community Health Workers (1) · Confidence Intervals (1) · Dexmedetomidine (1) · Early Intervention, Educational (1) · Ecological Momentary Assessment (1) · Economics, Behavioral (1)
Duke University (5) · Charles Drew University of Medicine and Science (4) · Johns Hopkins Bloomberg School of Public Health (4) · Assistance Publique - Hôpitaux de Paris (3) · Chinese University of Hong Kong (3) · Sun Yat-sen University (3) · University of Massachusetts, Worcester (3) · University of Pennsylvania (3) · Yuzuncu Yil University (3) · Case Western Reserve University (2) · Florida State University (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Geisinger Clinic (2) · Meharry Medical College (2) · Old Dominion University (2)
United States (87) · Turkey (Türkiye) (15) · France (11) · Canada (10) · China (7) · Hong Kong (6) · Italy (4) · United Kingdom (4) · Brazil (3) · Egypt (3) · Pakistan (3) · Thailand (3) · Germany (2) · Guatemala (2) · India (2)
Martha Sajatovic, MD (3) · Deanna Kepka, PhD, MPH (2) · Delesha M Carpenter, PhD (2) · Geoffrey Curran, PhD (2) · Joseph T Wu, PhD (2) · Kelli J England, PhD (2) · Yoann Athiel, MD (2) · Zeev Rosberger, PhD (2) · Aaron Scherer, PhD (1) · Abdullah Mbawah, Dr (1) · Abhijit Banerjee, PhD (1) · Abram L Wagner, PhD, MPH (1) · Akarin Hiransuthikul, MD, MSc (1) · Alex Fiks, MD MSCE (1)
PMID 32919524, PMID 10474547, PMID 11132515, PMID 12096176, PMID 16631354, PMID 16696824, PMID 17107245, PMID 17323327, PMID 17412850, PMID 17535948, PMID 18613959, PMID 19933540, PMID 20122743, PMID 22365840, PMID 22385676, PMID 22520532, PMID 23597377, PMID 23676442, PMID 25789200, PMID 27257809, PMID 27658738, PMID 30295176, PMID 31237839, PMID 31300334, PMID 31983293, PMID 32287039, PMID 32578755, PMID 33308277, PMID 33372943, PMID 33388335, PMID 33926540, PMID 34118498, PMID 34171345, PMID 34319359, PMID 34726454, PMID 34996644, PMID 35099523, PMID 35153096, PMID 35178652, PMID 35212640, PMID 35365344, PMID 35418436, PMID 35449064, PMID 35544437, PMID 35906015, PMID 36002223, PMID 36210252, PMID 36238712, PMID 36273221, PMID 36307830
R01CA279973 (2), R01MD018085 (2), R34MH078967 (2), 1KL2TR002554 (1), K01AG065440 (1), K01AI137123 (1), OT2HL158287 (1), P30AG024968 (1), P30AG064199 (1), R01AI166967 (1), R01AI182165 (1), R01LM012309 (1), R01MD016834 (1), R01MD016864 (1), R01MD016872 (1)