8 completed, 1 withdrawn. 6 Phase 3, 5 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 6 |
| Phase 2 | 5 | Completed 5 |
| Not applicable | 2 | Completed 2 |
Follow Sleeping Sickness: new trials by email Literature Review of Sleeping Sickness trials Research Report on Sleeping Sickness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Screen and Treat Implementation for HAT Control Screen&treat - Sleeping Sickness, Trypanosomiasis, African | Withdrawn | Institute of Tropical Medicine, Belgium | 2024-01-01 | 2024-02-02 | ||
| Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients Acoziborole - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 35 | 2022-07-09 | 2026-04-06 |
| Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis Serological field test for HAT, malaria rapid test, Immunologic laboratory tests - Human African Trypanosomiasis, Sleeping Sickness | Not applicable | Completed | Institut de Recherche pour le Developpement | 1095 | 2022-06-20 | 2024-04-05 |
| Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects Acoziborole, Placebo - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 1208 | 2021-12-30 | 2025-03-20 |
| Fexinidazole in Human African Trypanosomiasis Due to T. b. Rhodesiense Fexinidazole - Trypanosomiasis, African, Sleeping Sickness | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 45 | 2019-09-29 | 2025-01-30 |
| Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring Rapid diagnostic test (RDT); Serological and molecular tests on DBS - Human African Trypanosomiasis, Sleeping Sickness | Not applicable | Completed | Institut de Recherche pour le Developpement | 13747 | 2019-09-01 | 2022-04-15 |
| Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage Fexinidazole - Trypanosomiasis, African, Sleeping Sickness | Phase 3 | Completed | Drugs for Neglected Diseases | 174 | 2016-11-10 | 2025-01-08 |
| Efficacy and Safety of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis Due to T.b. Gambiense Acoziborole - Trypanosomiasis, African, Gambiense Trypanosomiasis | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 208 | 2016-10-11 | 2025-09-17 |
| Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 Fexinidazole, Nifurtimox, Eflornithine - Human African Trypanosomiasis (HAT), Sleeping Sickness | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 394 | 2012-10-01 | 2018-02-20 |
Trypanosomiasis, African (9) · Infections (5) · Disease (2) · Trypanosomiasis (2) · Hypersensitivity (1) · Neglected Diseases (1)
Euglenozoa Infections (9) · Parasitic Diseases (9) · Protozoan Infections (9) · Vector Borne Diseases (9) · Trypanosomiasis (7) · Infections (4) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Disease Attributes (1) · Immune System Diseases (1)
fexinidazole (3) · Eflornithine (1) · Nifurtimox (1) · Rapid Diagnostic Tests (1) · SCYX 7158 (1)
Drugs for Neglected Diseases (6) · Institut de Recherche pour le Developpement (2) · Institute of Tropical Medicine, Belgium (1)
Democratic Republic of the Congo (6) · Guinea (5) · Côte d’Ivoire (2) · Burkina Faso (1) · Central African Republic (1) · Malawi (1) · Republic of the Congo (1) · Uganda (1)
Digas Ngolo Tete, MPH (1) · Enock Matovu, Prof (1) · Mamadou Camara, PhD (1) · Martial N'Djetchi Kassi (1) · Oumou Camara (1) · Raquel Inocencio da Luz, PhD (1) · Veerle Lejon, PhD, HDR (1) · Victor Kande Betu Kumeso, Dr (1) · Victor Kande Betu Kumeso, Dr. (1) · Victor Kande Betu Kumeso, MD (1)
PMID 29113731, PMID 36460027, PMID 38978124, PMID 40288399, PMID 40288400