2 active not recruiting, 2 terminated, 1 withdrawn. 5 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Active not recruiting 2, Terminated 2, Withdrawn 1 |
| Phase 2 | 5 | Active not recruiting 2, Terminated 2, Withdrawn 1 |
Follow Refractory T Acute Lymphoblastic Leukemia: new trials by email Literature Review of Refractory T Acute Lymphoblastic Leukemia trials Research Report on Refractory T Acute Lymphoblastic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to Treat Anti-CD123 ADC IMGN632, Bone Marrow Aspiration and Biopsy, Cytarabine - Recurrent Acute Myeloid Leukemia, Recurrent B Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Withdrawn | Children's Oncology Group | 2023-08-01 | 2023-09-01 | |
| Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Recurrent Adult Lymphoblastic Lymphoma, Recurrent B Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 4 | 2022-02-17 | 2025-08-11 |
| Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL) AKR1C3-activated Prodrug AST-3424, Biopsy Procedure, Biospecimen Collection - Recurrent T Acute Lymphoblastic Leukemia, Refractory T Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Active not recruiting | SWOG Cancer Research Network | 67 | 2021-02-08 | 2026-09-01 |
| Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia Cyclophosphamide, Cytarabine, Dexamethasone - Recurrent B Acute Lymphoblastic Leukemia, Recurrent T Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 53 | 2019-04-03 | 2026-05-13 |
| Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia Biospecimen Collection, Computed Tomography, Lumbar Puncture - Recurrent Adult Lymphoblastic Lymphoma, Recurrent B Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 40 | 2018-08-13 | 2026-10-06 |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (5) · Burkitt Lymphoma (4) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Leukemia, Biphenotypic, Acute (1) · Leukemia, Myeloid, Acute (1) · Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (1)
Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5) · Immune System Diseases (5) · Immunoproliferative Disorders (5) · Leukemia (5) · Leukemia, Lymphoid (5) · Lymphatic Diseases (5) · Lymphoproliferative Disorders (5) · Neoplasms (5) · Neoplasms by Histologic Type (5) · DNA Virus Infections (4) · Epstein-Barr Virus Infections (4) · Herpesviridae Infections (4) · Infections (4) · Lymphoma (4)
Cytarabine (3) · Methotrexate (3) · Vincristine (3) · merphos (3) · Biopsy (2) · CT-P10 (2) · Calcium Dobesilate (2) · Cyclophosphamide (2) · Dexamethasone (2) · Prednisone (2) · Rituximab (2) · Specimen Handling (2) · auricularum (2) · deltacortene (2) · dexamethasone 21-phosphate (2)
M.D. Anderson Cancer Center (2) · Children's Oncology Group (1) · ECOG-ACRIN Cancer Research Group (1) · SWOG Cancer Research Network (1)
United States (4) · Puerto Rico (1)
Anjali S Advani (1) · Elias Jabbour (1) · Matthew A Kutny (1) · Neil D Palmisiano (1) · Nicholas Short, MD (1)
U10CA180820 (1), U10CA180886 (1), U10CA180888 (1)