17 completed. 17 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 17 |
| Phase 2 | 3 | Completed 3 |
Follow Prolymphocytic Leukemia: new trials by email Literature Review of Prolymphocytic Leukemia trials Research Report on Prolymphocytic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 anti-CD19/20-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Chinese PLA General Hospital | 100 | 2017-04-01 | 2020-09-02 |
| Selinexor and Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Aggressive Non-Hodgkin Lymphoma Selinexor, Ibrutinib, Pharmacological Study - Prolymphocytic Leukemia, Recurrent Adult Diffuse Large Cell Lymphoma | Phase 1 | Completed | Jennifer Woyach | 34 | 2015-06-09 | 2025-06-10 |
| Acalabrutinib in Combination With Anti-CD20 and Venetoclax in Relapsed/Refractory or Untreated CLL/SLL/PLL acalabrutinib, Obinutuzumab, Venetoclax - Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | Phase 1 | Completed | Acerta Pharma BV | 69 | 2014-12-22 | 2025-12-19 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Ofatumumab and Dinaciclib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia Dinaciclib, Laboratory Biomarker Analysis, Ofatumumab - Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2012-01-01 | 2018-03-15 |
| Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia cefepime hydrochloride - Adult Acute Lymphoblastic Leukemia, Adult Acute Myeloid Leukemia | Phase 1 | Completed | Wake Forest University Health Sciences | 70 | 2011-02-01 | 2018-07-18 |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Lenalidomide After Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancers Laboratory Biomarker Analysis, Lenalidomide, Pharmacological Study - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 | Phase 1 | Completed | National Cancer Institute (NCI) | 17 | 2010-11-24 | 2017-09-25 |
| Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL) carfilzomib, Cytokine Assessment, Pharmacodynamic Studies - B-cell Chronic Lymphocytic Leukemia, Hematopoietic/Lymphoid Cancer | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 21 | 2010-10-01 | 2016-05-09 |
| AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma Pharmacodynamic Studies, Fatigue Inventory, Pharmacogenomic studies - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Amir Mortazavi | 44 | 2010-05-04 | 2018-06-04 |
| Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma azacitidine, bortezomib, Correlative studies - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Pierluigi Porcu | 8 | 2010-05-01 | 2013-12-03 |
| CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy CART-19 - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | University of Pennsylvania | 26 | 2010-03-17 | 2023-06-22 |
| Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy sunitinib malate, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2009-08-01 | 2014-03-17 |
| Lenalidomide and Alvocidib in Treating Patients With Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Alvocidib Hydrochloride, Lenalidomide, Pharmacological Study - Anemia, Chronic Lymphocytic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 39 | 2008-08-01 | 2015-04-02 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction imatinib mesylate, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 60 | 2001-08-01 | 2013-02-07 |
| Autologous Stem Cell Transplant Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoma Autologous Hematopoietic Stem Cell Transplantation, Autologous-Allogeneic Tandem Hematopoietic Stem Cell Transplantation, Carmustine - Prolymphocytic Leukemia, Recurrent Adult Hodgkin Lymphoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 76 | 1999-09-01 | 2020-01-29 |
Leukemia, Prolymphocytic (17) · Leukemia, Lymphocytic, Chronic, B-Cell (16) · Lymphoma, Mantle-Cell (11) · Lymphoma, Follicular (10) · Lymphoma, Large B-Cell, Diffuse (10) · Burkitt Lymphoma (8) · Lymphoma, B-Cell, Marginal Zone (8) · Lymphoma, Large-Cell, Anaplastic (8) · Mycosis Fungoides (8) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (8) · Sezary Syndrome (8) · Lymphoma, Extranodal NK-T-Cell (7) · Lymphoma, Non-Hodgkin (7) · Lymphoma, T-Cell, Cutaneous (7) · Hodgkin Disease (6)
Hematologic Diseases (17) · Hemic and Lymphatic Diseases (17) · Immune System Diseases (17) · Immunoproliferative Disorders (17) · Leukemia (17) · Leukemia, Lymphoid (17) · Lymphatic Diseases (17) · Lymphoproliferative Disorders (17) · Neoplasms (17) · Neoplasms by Histologic Type (17) · Chronic Disease (16) · Disease Attributes (16) · Leukemia, B-Cell (16) · Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16)
Cyclophosphamide (2) · Cyclosporine (2) · Lenalidomide (2) · Mycophenolic Acid (2) · Pharmacogenomic Testing (2) · fludarabine phosphate (2) · Azacitidine (1) · Biopsy (1) · Bortezomib (1) · CTL019 chimeric antigen receptor (1) · Carmustine (1) · Cefepime (1) · Cyclosporins (1) · Cytarabine (1) · Etoposide (1)
National Cancer Institute (NCI) (6) · Fred Hutchinson Cancer Center (2) · Acerta Pharma BV (1) · Amir Mortazavi (1) · Chinese PLA General Hospital (1) · City of Hope Medical Center (1) · Jennifer Woyach (1) · Ohio State University Comprehensive Cancer Center (1) · Pierluigi Porcu (1) · University of Pennsylvania (1) · Wake Forest University Health Sciences (1)
United States (16) · Canada (1) · China (1) · Germany (1)
Jennifer Woyach, MD (2) · Amir Mortazavi, MD (1) · Colleen Delaney (1) · David Maloney (1) · John Deeken (1) · John Williamson (1) · Kerry Rogers, MD (1) · Kristie Blum (1) · Leslie Andritsos (1) · Maryam Fouladi (1) · Noelle Frey, MD (1) · Pierluigi Porcu (1) · Ramesh Ramanathan (1) · Ryotaro Nakamura (1)
PMID 22259028, PMID 24474568, PMID 25317870, PMID 26853648, PMID 26943915, PMID 28270022, PMID 30562587, PMID 31076448, PMID 31815579, PMID 31915195, PMID 32499241, PMID 33492438, PMID 34515338, PMID 34608724, PMID 41804087
P30CA016058 (4), U01CA076576 (3), N01CM00070 (1), N01CM62207 (1), P30CA015704 (1), P50CA140158 (1), R24HL074445 (1), R43HL106868 (1), RC2HL101844 (1), U01CA062487 (1), U01CA062491 (1), U01CA062502 (1), U01CA062505 (1), U01CA097452 (1), U01CA099168 (1)