7 completed. 7 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
| Phase 2 | 2 | Completed 2 |
Follow Plasmodium Falciparum: new trials by email Literature Review of Plasmodium Falciparum trials Research Report on Plasmodium Falciparum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Protective Efficacy of Pb(PfCS@UIS4) Pb(PfCS@UIS4)-infected mosquitoes, Challenge infection P. falciparum - Malaria,Falciparum, Plasmodium Falciparum | Phase 1 / Phase 2 | Completed | Radboud University Medical Center | 24 | 2017-05-29 | 2022-03-04 |
| Safety and Immunogenicity of Direct Venous Inoculation of a Radiation-attenuated PfSPZ Vaccine in Equatoguinean Adults PfSPZ Vaccine, Normal Saline - Malaria, Plasmodium Falciparum | Phase 1 | Completed | Sanaria Inc. | 33 | 2015-03-01 | 2016-03-02 |
| A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5 ChAd63 RH5 low dose, ChAd63 RH5 full dose, MVA RH5 low dose - Malaria, Plasmodium Falciparum | Phase 1 | Completed | University of Oxford | 26 | 2014-08-01 | 2015-12-03 |
| Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis PfSPZ Challenge, Normal Saline (NS) - Malaria, Plasmodium Falciparum | Phase 1 | Completed | Sanaria Inc. | 30 | 2012-09-01 | 2017-05-15 |
| Clinical Trial of the PfSPZ Vaccine Plasmodium falciparum Sporozoite (strain NF-54; Anopheles stephensi mosquitoes) Vaccine, Live, Inactivated (gamma irradiation) - Plasmodium Falciparum | Phase 1 | Completed | Sanaria Inc. | 80 | 2009-04-01 | 2014-09-10 |
| NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1 NMRC-M3V-Ad-PfCA, NMRC-MV-Ad-PfC, NMRC-M3V-Ad-PfCA - Plasmodium Falciparum | Phase 1 / Phase 2 | Completed | U.S. Army Medical Research and Development Command | 59 | 2006-10-12 | 2021-05-21 |
| PpPfs25/ISA51 and ScPvs25/ISA51 Vaccines for Malaria PpPfs25/ISA51 & ScPvs25/ISA51 - Plasmodium Falciparum, Plasmodium Vivax Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2005-03-07 | 2017-07-02 |
Malaria, Falciparum (7) · Malaria (3) · Adenoviridae Infections (1) · Malaria, Vivax (1)
Infections (7) · Mosquito-Borne Diseases (7) · Parasitic Diseases (7) · Protozoan Infections (7) · Vector Borne Diseases (7) · Malaria (4) · DNA Virus Infections (1) · Virus Diseases (1)
Saline Solution (2) · Vaccines (1)
Sanaria Inc. (3) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Radboud University Medical Center (1) · U.S. Army Medical Research and Development Command (1) · University of Oxford (1)
United States (3) · Netherlands (2) · Equatorial Guinea (1) · United Kingdom (1)
Cindy Tamminga, MD, MPH (1) · Judith E Epstein, M.D. (1) · Robert Sauerwein, MD (1) · Robert Sauerwein, MD PhD (1) · Salim Abdulla, MD, PhD (1)
PMID 18612426, PMID 21903775, PMID 22003383, PMID 22003411, PMID 23899517, PMID 25211344, PMID 26292027, PMID 26292257, PMID 27695088, PMID 29141739, PMID 32434846