5 completed, 2 recruiting, 1 active not recruiting, 1 terminated. 5 Phase 2, 2 Not applicable, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 3 | 2 | Active not recruiting 1, Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Non-obstructive Hypertrophic Cardiomyopathy: new trials by email Literature Review of Non-obstructive Hypertrophic Cardiomyopathy trials Research Report on Non-obstructive Hypertrophic Cardiomyopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy Ninerafaxstat 200mg MR, Placebo - Non-obstructive Hypertrophic Cardiomyopathy | Phase 2 | Recruiting | Imbria Pharmaceuticals, Inc. | 165 | 2025-10-06 | 2026-10-26 |
| Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy myPACE+ algorithm - Non-obstructive Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy | Not applicable | Terminated | Montefiore Medical Center | 1 | 2025-10-02 | 2026-02-11 |
| A Phase II Clinical Study of HRS-1893 in Non-obstructive Hypertrophic Cardiomyopathy HRS-1893, HRS-1893 placebo - Non-obstructive Hypertrophic Cardiomyopathy | Phase 2 | Completed | Shandong Suncadia Medicine Co., Ltd. | 84 | 2025-02-25 | 2026-08-24 |
| A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy Sotagliflozin, Placebo - Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hypertrophic Cardiomyopathy | Phase 3 | Active not recruiting | Lexicon Pharmaceuticals | 500 | 2024-09-24 | 2026-08-26 |
| Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy Verapamil, Bisoprolol, Placebo - Non-obstructive Hypertrophic Cardiomyopathy | Phase 4 | Recruiting | Morten Steen Kvistholm Jensen | 100 | 2022-08-10 | 2025-03-20 |
| A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy Trial IMB-1018972, Placebo - Non-obstructive Hypertrophic Cardiomyopathy | Phase 2 | Completed | Imbria Pharmaceuticals, Inc. | 67 | 2021-06-14 | 2024-04-23 |
| A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM mavacamten - Hypertrophic Cardiomyopathy, Obstructive Hypertrophic Cardiomyopathy | Phase 2 / Phase 3 | Completed | Bristol-Myers Squibb | 314 | 2018-09-27 | 2026-02-20 |
| A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) mavacamten, Placebo - Non-obstructive Hypertrophic Cardiomyopathy | Phase 2 | Completed | MyoKardia, Inc. | 59 | 2018-03-30 | 2022-08-09 |
| Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy CPAP - Non-obstructive Hypertrophic Cardiomyopathy, Obstructive Hypertrophic Cardiomyopathy | Not applicable | Completed | University of Sao Paulo | 26 | 2012-01-01 | 2014-12-19 |
Cardiomyopathy, Hypertrophic (6) · Cardiomyopathies (1)
Aortic Stenosis, Subvalvular (6) · Aortic Valve Disease (6) · Aortic Valve Stenosis (6) · Cardiovascular Diseases (6) · Heart Diseases (6) · Heart Valve Diseases (6) · Cardiomyopathies (5)
MYK-461 (2) · (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol (1) · Bisoprolol (1) · Verapamil (1)
Imbria Pharmaceuticals, Inc. (2) · Bristol-Myers Squibb (1) · Lexicon Pharmaceuticals (1) · Montefiore Medical Center (1) · Morten Steen Kvistholm Jensen (1) · MyoKardia, Inc. (1) · Shandong Suncadia Medicine Co., Ltd. (1) · University of Sao Paulo (1)
United States (6) · United Kingdom (4) · Belgium (3) · France (3) · Germany (3) · Italy (3) · Poland (3) · Portugal (3) · Brazil (2) · Czechia (2) · Denmark (2) · Israel (2) · Netherlands (2) · Spain (2) · Argentina (1)
PMID 27167210, PMID 32466879, PMID 38176782, PMID 39217450, PMID 42636950