4 not yet recruiting, 1 completed. 4 Phase 2, 2 Phase 1, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Not yet recruiting 4 |
| Phase 1 | 2 | Not yet recruiting 2 |
| Early Phase 1 | 1 | Completed 1 |
Follow NF2: new trials by email Literature Review of NF2 trials Research Report on NF2
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Selumetinib for NF2-Related Schwannomatosis Selumetinib - Neurofibromatosis Type 2, NF2 | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 20 | 2026-12-01 | 2026-10-28 |
| Luvometinib in Combination With Serplulimab for NF2-Related Tumors Luvometinib, Serplulimab - NF2-related Schwannomatosis, NF2 | Phase 1 / Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 30 | 2026-07-31 | 2026-07-16 |
| Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2) Selumetinib 25mg/m2, Luvometinib, Serplulimab - Neurofibromatosis Type 2, Vestibular Schwannoma | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-07-18 | 2026-07-20 |
| Study to Determine Optimal Dose, Evaluate the Efficacy and Safety of PRG-N-01 in Patients With Neurofibromatosis Type II Trineumin - Neurofibromatosis Type II, NF2 | Phase 1 / Phase 2 | Not yet recruiting | PRG Science & Technology Co., Ltd. | 25 | 2026-07-01 | 2026-01-23 |
| Concentration and Activity of Lapatinib in Vestibular Schwannomas lapatinib - Vestibular Schwannoma, NF2 | Early Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 26 | 2009-06-01 | 2021-01-12 |
Neurofibromatosis 2 (5) · Neuroma, Acoustic (4) · Meningioma (3) · Ependymoma (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Cranial Nerve Diseases (5) · Cranial Nerve Neoplasms (5) · Ear Diseases (5) · Genetic Diseases, Inborn (5) · Heredodegenerative Disorders, Nervous System (5) · Neoplasms (5) · Neoplasms by Histologic Type (5) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Nerve Tissue (5) · Neoplastic Syndromes, Hereditary (5) · Nerve Sheath Neoplasms (5) · Nervous System Diseases (5) · Neurilemmoma (5) · Neurocutaneous Syndromes (5)
Beijing Tiantan Hospital (3) · PRG Science & Technology Co., Ltd. (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1)
China (3) · United States (1)