8 completed, 4 not yet recruiting, 4 recruiting, 2 active not recruiting. 12 Not applicable, 3 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 5, Active not recruiting 2, Not yet recruiting 2, Recruiting 2, Enrolling by invitation 1 |
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
| Phase 1 | 2 | Completed 2 |
Follow Molar Incisor Hypomineralisation: new trials by email Literature Review of Molar Incisor Hypomineralisation trials Research Report on Molar Incisor Hypomineralisation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization pulpotomy for MIH affected immature PFMs, partial pulpotomy for MIH affected immature PFMs, pulpotomy for non-MIH affected immature PFMs - Molar Incisor Hypomineralisation, Irreversible Pulpitis | Not applicable | Active not recruiting | Alaa Khafagy | 132 | 2026-05-01 | 2026-10-01 |
| The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial Salvadora persica (miswak), Fluoridated Toothpaste - Molar Incisor Hypomineralisation | Not applicable | Not yet recruiting | King Abdulaziz University | 30 | 2026-01-29 | 2026-01-21 |
| Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH) Molar Incisor Hypomineralisation | Recruiting | University of Basel | 45 | 2026-01-09 | 2026-07-27 | |
| Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH) Molar Incisor Hypomineralisation, Enamel Breakdown | Recruiting | University of Basel | 45 | 2026-01-09 | 2026-07-27 | |
| Nanohydroxyapatite Versus Sodium Fluoride Varnish in Remineralizing MIH Anterior Teeth Nanohydroxyapatite Varnish Application, Sodium Fluoride Varnish Application - Fluoride Varnishes, Molar Incisor Hypomineralisation | Not applicable | Recruiting | Tanta University | 26 | 2026-01-03 | 2026-10-26 |
| Hydroxyapatite vs Fluoride Toothpaste for MIH Remineralization non fluoridated hydroxyapatite tooth paste (KAREX KINDER tooth paste), fluoridated toothpaste (Colgate Total PROTECTION ACTIVE) - Molar Incisor Hypomineralisation | Phase 2 | Not yet recruiting | Dubai Health | 160 | 2025-11-01 | 2025-09-16 |
| Etch-bleach-seal Technique in Managing Opacities Related MIH Using Icon® Sodium hypochlorite 5.25%, ICON resin infiltration Material group in vivo - Molar Incisor Hypomineralisation | Not applicable | Completed | Latakia University | 15 | 2025-08-25 | 2026-09-10 |
| Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth nano hydroxy apatite varnish, Potassium Nitrate Gel, Varnishes, Fluoride - Molar Incisor Hypomineralisation | Not applicable | Not yet recruiting | Cairo University | 48 | 2025-06-01 | 2025-04-24 |
| Effect of Resin Infiltration on Hypersensitivity and Satisfaction in Children With Enamel Defects Resin infiltration - Molar Incisor Hypomineralisation, Enamel Hypoplasia | Not applicable | Completed | Gizem Tıraşçı | 40 | 2025-03-14 | 2026-03-30 |
| Prevalence of Hypomineralized Second Primary Molars and Its Association with Molar-Incisor Hypomineralization. Molar Incisor Hypomineralisation, Molar Incisor Hypomineralization | Not yet recruiting | Cairo University | 825 | 2025-01-01 | 2024-12-16 | |
| Selective Versus Non-selective Caries Excavation in MIH Affected Teeth. Selective caries removal, Non-Selective caries removal - Molar Incisor Hypomineralisation, Dental Caries | Not applicable | Enrolling by invitation | King Abdullah University Hospital | 60 | 2024-09-01 | 2025-08-26 |
| Comparison of Two Minimally Invasive Approaches for Masking Molar-Incisor Hypomineralization Opacities Resin infiltration, Etch Bleach Seal Technique - Molar Incisor Hypomineralisation, Enamel Hypomineralization | Not applicable | Completed | Pamukkale University | 64 | 2024-05-06 | 2026-03-27 |
| SleeperOne® 5 Intraosseous Anesthesia in MIH SleeperOne® 5 Computer-Controlled Intraosseous Anesthesia, Conventional Local Anesthesia - Molar Incisor Hypomineralisation | Not applicable | Completed | Ankara University | 35 | 2024-01-01 | 2026-08-06 |
| Intraosseous Anesthesia in MIH-Affected Teeth Intraosseous anesthesia., Local infiltration anesthesia - Molar Incisor Hypomineralisation | Not applicable | Active not recruiting | University of Zagreb | 50 | 2023-10-01 | 2026-03-09 |
| This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization. Immediate restoration (resin- based) after blot-drying silver fluoride application, Immediate restoration (GI- based) after blot-drying silver fluoride application, Immediate restoration (Resin based) after rinsing silver fluoride application - Molar Incisor Hypomineralisation, Children | Not applicable | Recruiting | Hacettepe University | 104 | 2023-07-31 | 2024-10-15 |
| Molar Incisor Hypomineralisation and Dental Anomalies This is a non intervention - observation only study - Molar Incisor Hypomineralisation | Completed | Sheffield Teaching Hospitals NHS Foundation Trust | 1279 | 2022-11-29 | 2024-08-21 | |
| Articaine 4% Versus Lidocaine 2% for Local Anesthesia of MIH-affected Maxillary Molars Lidocaine 2%, Articaine 4% - Molar Incisor Hypomineralisation | Phase 1 / Phase 2 | Completed | Latakia University | 26 | 2022-10-17 | 2023-05-03 |
| Local Anesthesia With Lidocaine or Articaine for Molars Affected by MIH Lidocaine 2%, Articaine 4% - Molar Incisor Hypomineralisation | Phase 1 / Phase 2 | Completed | Latakia University | 20 | 2022-01-22 | 2022-07-15 |
| Comparison of Intraosseous Anaesthesia Using a Computerized System (QuickSleeper) to Conventional Anesthesia intraosseous anaesthesia using a computerized system, conventional anasthesia - Deep Caries, Molar Incisor Hypomineralisation | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 158 | 2015-01-01 | 2017-02-23 |
Molar Hypomineralization (19) · Dental Caries (2) · Dental Enamel Hypomineralization (2) · Anodontia (1) · Dental Enamel Hypoplasia (1) · Hypersensitivity (1) · Tooth Abnormalities (1) · Tooth Discoloration (1)
Congenital Abnormalities (19) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (19) · Developmental Defects of Enamel (19) · Stomatognathic Diseases (19) · Stomatognathic System Abnormalities (19) · Tooth Diseases (19) · Tooth Abnormalities (18) · Dental Enamel Hypomineralization (17) · Tooth Demineralization (2) · Immune System Diseases (1)
Anesthesia, Local (1) · Fluorides, Topical (1) · Pulpotomy (1)
Latakia University (3) · Cairo University (2) · University of Basel (2) · Alaa Khafagy (1) · Ankara University (1) · Assistance Publique - Hôpitaux de Paris (1) · Dubai Health (1) · Gizem Tıraşçı (1) · Hacettepe University (1) · King Abdulaziz University (1) · King Abdullah University Hospital (1) · Pamukkale University (1) · Sheffield Teaching Hospitals NHS Foundation Trust (1) · Tanta University (1) · University of Zagreb (1)
Turkey (Türkiye) (4) · Syria (3) · Egypt (2) · Switzerland (2) · Croatia (1) · France (1) · Jordan (1) · United Kingdom (1)
Carlalberta Verna, Professor Dr.med.dent. (2) · Mai Haidar, Dr (2) · Nabih Raslan, Dr (2) · Arif Bolaca, Dr (1) · Eirini Stratigaki, Dr.med.dent (1) · Elif Ballikaya, DDS, PhD (1) · Helen Rodd, BDS PhD (1) · Zafer Cehreli, DDS, PhD (1)
PMID 26163031, PMID 30883951, PMID 37526883, PMID 38457899, PMID 40744295, PMID 41915094, PMID 42709399