10 completed, 2 active not recruiting. 10 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 9, Active not recruiting 1 |
| Phase 2 | 2 | Active not recruiting 1, Completed 1 |
Follow Marburg Virus Disease: new trials by email Literature Review of Marburg Virus Disease trials Research Report on Marburg Virus Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-MARV-GP Vaccine in Adults in Good General Health rVSV∆G-MARV-GP, Placebo - Marburg Virus Disease | Phase 1 | Active not recruiting | International AIDS Vaccine Initiative | 112 | 2026-03-27 | 2026-10-30 |
| A Trial to Evaluate Safety, Tolerability, and Immune Responses of an Investigational Monovalent Chimpanzee Adenoviral Vectored Marburg Virus Vaccine in Healthy Adults cAd3-Marburg Vaccine, Placebo - Marburg Virus Disease | Phase 2 | Active not recruiting | Albert B. Sabin Vaccine Institute | 200 | 2025-04-14 | 2026-09-10 |
| Study to Evaluate the Recombinant VSV (rVSV)-Marburg Virus Vaccine Candidate (PHV01) in Healthy Adult Subjects PHV01, Placebo - Marburg Virus Disease | Phase 1 | Completed | Public Health Vaccines LLC | 36 | 2024-02-05 | 2025-09-05 |
| Monovalent Chimpanzee Adenoviral-Vectored Marburg Virus Vaccine in Healthy Adults cAd3-Marburg vaccine, Placebo - Marburg Virus Disease | Phase 2 | Completed | Albert B. Sabin Vaccine Institute | 126 | 2023-10-19 | 2025-07-23 |
| Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults cAd3-Marburg, cAd3-EBO-S - Ebola Virus Disease, Marburg Virus Disease | Phase 1 | Completed | Albert B. Sabin Vaccine Institute | 32 | 2021-01-06 | 2022-08-03 |
| A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430 galidesivir, placebo - Marburg Virus Disease | Phase 1 | Completed | BioCryst Pharmaceuticals | 32 | 2018-12-10 | 2021-07-23 |
| cAd3-Marburg Vaccine in Healthy Adults cAd3-Marburg vaccine - Marburg Virus Disease | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 40 | 2018-10-09 | 2022-08-11 |
| A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Ad26 Zaire Ebola Vaccine, MVA Multi-Filo Ebola Vaccine - Ebola Disease, Marburg Disease | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 65 | 2017-03-24 | 2025-07-29 |
| A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers AVI-7288, Placebo - Marburg Hemorrhagic Fever | Phase 1 | Completed | Sarepta Therapeutics, Inc. | 40 | 2013-05-01 | 2014-05-07 |
| Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus AVI-6003, Placebo - Marburg Hemorrhagic Fever | Phase 1 | Completed | Sarepta Therapeutics, Inc. | 30 | 2011-05-01 | 2012-05-07 |
| Evaluating an Ebola and a Marburg Vaccine in Uganda Ebola vaccine, Marburg vaccine, Placebo injection - Ebola Virus Disease, Marburg Virus Disease | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 108 | 2010-02-01 | 2013-01-28 |
| Ebola and Marburg Virus Vaccines VRC-EBODNA023-00-VP, VRC-MARDNA025-00-VP - Ebola Vaccines, Marburg Virus Disease | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 20 | 2008-01-25 | 2017-07-02 |
Hemorrhagic Fever, Ebola (4) · Acquired Immunodeficiency Syndrome (1) · Acquired angioedema (1) · Angioedemas, Hereditary (1) · Communicable Diseases (1) · Creutzfeldt-Jakob Syndrome (1) · Disseminated Intravascular Coagulation (1) · Hemorrhagic Fevers, Viral (1) · Hepatitis B (1) · Hepatitis C (1)
Animal Diseases (12) · Filoviridae Infections (12) · Infections (12) · Monkey Diseases (12) · Mononegavirales Infections (12) · Primate Diseases (12) · RNA Virus Infections (12) · Virus Diseases (12) · Hemorrhagic Fevers, Viral (11) · Angioedema (1) · Blood Coagulation Disorders (1) · Blood-Borne Infections (1) · Brain Diseases (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1)
AVI-7288 (1) · Ebola Vaccines (1) · Saline Solution (1) · galidesivir (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · Albert B. Sabin Vaccine Institute (3) · Sarepta Therapeutics, Inc. (2) · BioCryst Pharmaceuticals (1) · International AIDS Vaccine Initiative (1) · Public Health Vaccines LLC (1)
United States (10) · Uganda (2) · Kenya (1)
Alison Heald, MD (1) · Apinya B Vutikullird, MD (1) · Daniel Dickerson, MD, PhD (1) · David Hoover, MD (1) · Hannah Kibuuka, MBChB, MMed, MPH (1) · Joan Fusco, PhD (1) · Melinda Hamer, M.D. (1) · Michael Stevenson, MD (1) · Mohamed Al-Ibrahim, MD (1) · Richard Kenney, MD (1) · Roxana Rustomjee, MBChB (1) · Tuan Le, MD (1)
PMID 1538192, PMID 15577929, PMID 16375711, PMID 25225676, PMID 25426834, PMID 25540891, PMID 26200980, PMID 35182042, PMID 36709074, PMID 39715748, PMID 8237108
272201300017C-18-0-1 (1)