6 active not recruiting, 3 recruiting, 2 completed, 2 withdrawn. 6 Phase 2, 4 Phase 1, 2 Phase 3, 1 Early Phase 1, 1 Not applicable.
Follow Locally Advanced Breast Carcinoma: new trials by email Literature Review of Locally Advanced Breast Carcinoma trials Research Report on Locally Advanced Breast Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer Biopsy Procedure, Biospecimen Collection, Echocardiography Test - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2026-10-06 | 2026-10-16 |
| An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial Diagnostic Mammography, Resection, Ultrasound Imaging - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 1 | Recruiting | Mayo Clinic | 20 | 2025-08-29 | 2026-09-23 |
| Safety, Ultrasound Conspicuity, and Migration of Twinkling Markers in Patients With Locally Advanced Breast Cancer Magnetic Resonance Imaging, Mammogram, Ultrasound - Anatomic Stage III Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma | Suspended | Mayo Clinic | 15 | 2023-03-21 | 2026-03-31 | |
| Pre-analytical Factors Affecting ctDNA Analysis in Early and Locally Advanced Breast Cancer Biospecimen Collection, Electronic Health Record Review - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Completed | Mayo Clinic | 114 | 2022-07-07 | 2025-09-09 | |
| Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations Biopsy Procedure, Biospecimen Collection, Computed Tomography - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 29 | 2021-04-26 | 2026-08-19 |
| SHAPE Neoadjuvant Chemotherapy Response Contrast-Enhanced Ultrasound, Perflutren Lipid Microspheres, Ultrasound - Anatomic Stage III Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma | Phase 2 / Phase 3 | Active not recruiting | Kibo Nam | 122 | 2021-04-19 | 2026-09-23 |
| Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer Abexinostat Tosylate, Fulvestrant, Palbociclib - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 | Withdrawn | Pamela Munster | 2021-03-31 | 2021-05-18 | |
| INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study Pelareorep, Quality-of-Life Assessment, Questionnaire Administration - Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma | Phase 2 | Active not recruiting | Mridula George, MD | 25 | 2020-07-13 | 2025-04-04 |
| Cryoablation, Atezolizumab/Nab-paclitaxel for Locally Advanced or Metastatic Triple Negative Breast Cancer Atezolizumab, Cryosurgery, Nab-paclitaxel - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Early Phase 1 | Withdrawn | Mayo Clinic | 2020-01-23 | 2023-01-06 | |
| Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma Indocyanine Green, Lymphangiography, Lymphovenous Bypass - Anatomic Stage III Breast Cancer AJCC v8, Breast Inflammatory Carcinoma | Not applicable | Recruiting | M.D. Anderson Cancer Center | 252 | 2018-08-14 | 2026-05-26 |
| Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer Cyclophosphamide, Doxorubicin, Laboratory Biomarker Analysis - Breast Inflammatory Carcinoma, Locally Advanced Breast Carcinoma | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 34 | 2018-02-19 | 2026-02-12 |
| Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy Biopsy, Biospecimen Collection, Laboratory Biomarker Analysis - Advanced Breast Carcinoma, Locally Advanced Breast Carcinoma | Active not recruiting | Mayo Clinic | 68 | 2017-11-13 | 2026-06-09 | |
| Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic Biospecimen Collection, Computed Tomography, Entinostat - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 608 | 2014-03-29 | 2026-10-01 |
| Nab-Paclitaxel in Treating Older Patients With Locally Advanced or Metastatic Breast Cancer Laboratory Biomarker Analysis, Nab-paclitaxel, Questionnaire Administration - Locally Advanced Breast Carcinoma, Metastatic Breast Carcinoma | Phase 2 | Active not recruiting | City of Hope Medical Center | 40 | 2012-06-19 | 2026-07-10 |
| Veliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer Biopsy, Biospecimen Collection, Carboplatin - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 2 | Completed | National Cancer Institute (NCI) | 77 | 2010-06-30 | 2025-08-15 |
Breast Neoplasms (8) · Neoplasm Metastasis (3) · Triple Negative Breast Neoplasms (3) · Inflammatory Breast Neoplasms (2) · Ovarian Neoplasms (2) · Carcinoma, Endometrioid (1) · Fallopian Tube Neoplasms (1) · Melanoma (1) · Pancreatic Neoplasms (1) · Prostatic Neoplasms (1) · Stomach Neoplasms (1)
Breast Diseases (11) · Neoplasms (11) · Neoplasms by Site (11) · Skin Diseases (11) · Skin and Connective Tissue Diseases (11) · Breast Neoplasms (3) · Neoplastic Processes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Adnexal Diseases (2) · Endocrine Gland Neoplasms (2) · Endocrine System Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Genital Diseases (2)
Specimen Handling (5) · Biopsy (4) · Magnetic Resonance Spectroscopy (4) · High-Energy Shock Waves (3) · Taxes (3) · 130-nm albumin-bound paclitaxel (2) · Albumin-Bound Paclitaxel (2) · 2C4 antibody (1) · CX 5461 (1) · Carboplatin (1) · Cryosurgery (1) · Cyclophosphamide (1) · Doxorubicin (1) · Fulvestrant (1) · Goserelin (1)
Mayo Clinic (5) · National Cancer Institute (NCI) (4) · M.D. Anderson Cancer Center (2) · City of Hope Medical Center (1) · Kibo Nam (1) · Mridula George, MD (1) · Pamela Munster (1)
United States (13) · Canada (1) · South Africa (1)
A P Chen (1) · Barbara A. Pockaj, MD (1) · Christine U Lee, M.D., Ph.D. (1) · Christine U. Lee, MD, PhD (1) · Ciara O'Sullivan, M.B., B.Ch. (1) · Emmanuel M Gabriel (1) · Filipa Lynce (1) · Joanne Mortimer (1) · Kibo Nam, MD (1) · Mark Schaverien (1) · Mina Sedrak (1) · Mridula A George (1) · Pamela N Munster, MD (1) · Rachel Layman, MD (1) · Roisin M Connolly (1)
PMID 33084020, PMID 34357781, PMID 41116969
P30CA033572 (2), N01CM00032 (1), N01CM00038 (1), N01CM00039 (1), N01CM00071 (1), N01CM00099 (1), N01CM62201 (1), N01CM62202 (1), N01CM62203 (1), N01CM62209 (1), P30CA016672 (1), P30CA072720 (1), P50CA168504 (1), R01EB033008 (1), R37CA234428 (1)