14 completed. 14 Phase 2, 5 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 14 |
| Phase 3 | 5 | Completed 5 |
| Phase 1 | 1 | Completed 1 |
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous Adipose-Derived Adult Stem Cell Implantation for Corneal Diseases (ADASCs-CT-CD) Implantation, Lipoaspiration - Ophthalmological Disorder, Corneal Dystrophy | Phase 2 | Completed | Vissum, Instituto Oftalmológico de Alicante | 15 | 2022-04-19 | 2023-05-06 |
| Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position PXL 330 Platinum device/Riboflavin - Keratoconus, Unstable, Ectasia Corneal | Phase 2 | Completed | Eye Specialists of Indiana | 12 | 2020-05-04 | 2024-08-29 |
| Comparison of Standard vs. Accelerated Corneal Crosslinking riboflavin 0.1%, Riboflavin 0.1% - Keratoconus, Ectasia Corneal | Phase 2 / Phase 3 | Completed | Price Vision Group | 508 | 2019-04-16 | 2026-09-17 |
| Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients IVMED-80, Placebo - Keratoconus, Corneal Ectasia | Phase 1 / Phase 2 | Completed | iVeena Delivery Systems, Inc. | 38 | 2019-02-08 | 2022-02-15 |
| Endothelial Cell Loss After Penetrating Keratoplasty PKP - Keratoconus | Phase 2 / Phase 3 | Completed | Alexandria University | 8 | 2018-07-01 | 2020-07-07 |
| Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Dexamethasone implant OZURDEX - Keratoconus, Fuchs' Endothelial Dystrophy | Phase 2 | Completed | Centre Hospitalier Universitaire de Saint Etienne | 14 | 2017-01-10 | 2019-08-16 |
| Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Optical Coherence Tomography - Corneal Neovascularisation, Keratoconus | Phase 2 | Completed | Medical University of Vienna | 13 | 2014-03-14 | 2021-09-08 |
| Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus collagen cross-linking procedure (total removal), collagen cross-linking procedure (partial removal) - Keratoconus | Phase 2 | Completed | Isfahan University of Medical Sciences | 22 | 2012-07-01 | 2013-03-13 |
| Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus CXL without epithelial removal, CXL with epithelial removal - Keratoconus | Phase 2 | Completed | University Hospital of North Norway | 20 | 2010-07-01 | 2014-12-12 |
| Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia Riboflavin, UVX light - Keratoconus, Post-Refractive Ectasia | Phase 2 | Completed | Price Vision Group | 510 | 2010-05-01 | 2018-06-06 |
| Corneal Sensitivity Cross-linking Keratoconus Cochet-Bonnet esthesiometer central corneal sensitivity - Keratoconus | Phase 2 / Phase 3 | Completed | Instituto de Olhos de Goiania | 19 | 2009-03-01 | 2012-12-06 |
| Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Corneal collagen, Sham comparator - Progressive Keratoconus, Corneal Ectasia | Phase 2 / Phase 3 | Completed | Emory University | 160 | 2007-12-01 | 2010-09-02 |
| Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus Riboflavin/UVA crosslinking, Sham treatment - Keratoconus | Phase 2 / Phase 3 | Completed | University Hospital Freiburg | 30 | 2007-08-01 | 2013-01-17 |
| Lamellar Transplant With Lyophilized Corneas Lamellar transplant with lyophilized corneas - Keratoconus | Phase 2 | Completed | Federal University of São Paulo | 20 | 2005-12-01 | 2006-12-12 |
Corneal Diseases (3) · Dilatation, Pathologic (2) · Corneal Dystrophies, Hereditary (1) · Corneal Dystrophy, Congenital Stromal (1) · Corneal Neovascularization (1) · Eye Diseases (1) · Fuchs' Endothelial Dystrophy (1)
Eye Diseases (13) · Corneal Diseases (11) · Pathological Conditions, Signs and Symptoms (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Eye Diseases, Hereditary (2) · Genetic Diseases, Inborn (2) · Pathological Conditions, Anatomical (2) · Corneal Dystrophies, Hereditary (1) · Metaplasia (1) · Neovascularization, Pathologic (1) · Pathologic Processes (1)
Riboflavin (2) · Corneal Cross-Linking (1) · Drug Implants (1) · Tomography, Optical Coherence (1)
Price Vision Group (2) · Alexandria University (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Emory University (1) · Eye Specialists of Indiana (1) · Federal University of São Paulo (1) · Instituto de Olhos de Goiania (1) · Isfahan University of Medical Sciences (1) · Medical University of Vienna (1) · University Hospital Freiburg (1) · University Hospital of North Norway (1) · Vissum, Instituto Oftalmológico de Alicante (1) · iVeena Delivery Systems, Inc. (1)
United States (4) · Brazil (2) · Austria (1) · Egypt (1) · France (1) · Germany (1) · Iran (1) · Mexico (1) · Norway (1) · Spain (1)
Aleksandar Stojanovic, MD (1) · Arturo Chayet, MD (1) · Balamurali K. Ambati, MD, PhD (1) · Behrooz Rahimi, MD (1) · Belquiz A Nassaralla, MD PhD (1) · Ehab Mossallam, PhD (1) · Francis W Price, Jr., MD (1) · Francis W Price, MD (1) · Jorge L Alio, MD, PhD (1) · Katarzyna Napora, MD, PhD (1) · Philip Maier, MD (1) · R. Doyle Stulting, MD, PhD (1) · Roberta JM Farias, MD (1)
PMID 25050368, PMID 25365551, PMID 25538907, PMID 26194634, PMID 28486314, PMID 29103962, PMID 29203068, PMID 30772348, PMID 32301973, PMID 33164825, PMID 33181549, PMID 33591032, PMID 33708786, PMID 34426402, PMID 41126474
2016 (1), 2018 (1)