1 completed, 1 recruiting, 1 terminated. 3 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 1, Recruiting 1, Terminated 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Kasabach-Merritt Syndrome: new trials by email Literature Review of Kasabach-Merritt Syndrome trials Research Report on Kasabach-Merritt Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low- vs High-Dose Sirolimus With Prednisolone for KHE and KMP Sirolimus (RAPAMUNE) - Kaposiform Hemangioendothelioma (KHE), Kasabach Merritt Phenomenon | Phase 2 / Phase 3 | Recruiting | Yi Ji | 76 | 2026-06-16 | 2026-06-18 |
| A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Vincristine, Sirolimus - Kaposiform Hemangioendothelioma (KHE), Kasabach-Merritt Syndrome | Phase 2 | Terminated | Boston Children's Hospital | 4 | 2017-06-14 | 2023-09-21 |
| Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma Sirolimus, Prednisolone - Kaposiform Hemangioendothelioma, Kasabach Merritt Phenomenon | Phase 2 | Completed | West China Hospital | 30 | 2017-06-01 | 2022-04-21 |
Kaposiform Hemangioendothelioma (3) · Hemangioendothelioma (1) · Tufted angioma (1) · Vascular Malformations (1)
Blood Platelet Disorders (3) · Cytopenia (3) · Hemangioma (3) · Hematologic Diseases (3) · Hemic and Lymphatic Diseases (3) · Neoplasms (3) · Neoplasms by Histologic Type (3) · Neoplasms, Vascular Tissue (3) · Thrombocytopenia (3) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Sirolimus (3) · Prednisolone (1) · Vincristine (1)
Boston Children's Hospital (1) · West China Hospital (1) · Yi Ji (1)
China (2) · United States (1)
Denise Adams, MD (1) · Jiangyuan Zhou, MD (1) · Yi Ji (1) · Yi Ji, MD, PhD (1)
PMID 35030255, PMID 22871490, PMID 28486787, PMID 31489702, PMID 32014025, PMID 33580918, PMID 34082006, PMID 34273457, PMID 3691614, PMID 3936944, PMID 39831682, PMID 40107509, PMID 41831614