18 completed, 5 active not recruiting, 4 unknown, 3 recruiting. 17 Phase 2, 9 Phase 1, 8 Phase 3, 1 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AMT-151 in Patients With Selected Advanced Solid Tumours AMT-151 - Advanced Solid Tumor, Advanced Cancer | Phase 1 | Unknown | Multitude Therapeutics Inc. | 30 | 2023-01-25 | 2023-10-19 |
| Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma Biospecimen Collection, Carboplatin, Computed Tomography - Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 360 | 2022-11-16 | 2026-10-02 |
| Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma Biospecimen Collection, Computed Tomography, Ipilimumab - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 81 | 2022-06-02 | 2026-10-28 |
| A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα) ELU001 - Ovarian Cancer, Ovarian Neoplasms | Phase 1 / Phase 2 | Terminated | Elucida Oncology | 79 | 2021-09-13 | 2024-08-07 |
| Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer Carboplatin, Computed Tomography, Paclitaxel - Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 813 | 2019-08-22 | 2026-10-21 |
| Determine the Utility of Liquid Biopsies and Tumor Molecular Profiling in Predicting Recurrence in Endometrial Cancers Biospecimen Collection, Liquid Biopsy, Pap Smear - Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma | Recruiting | M.D. Anderson Cancer Center | 1000 | 2019-06-18 | 2026-10-07 | |
| Mirvetuximab Soravtansine (IMGN853) and Bevacizumab in Patients With Endometrial Cancer Mirvetuximab Soravtansine, Bevacizumab - Endometrial Cancer, Endometrial Adenocarcinoma | Phase 2 | Withdrawn | University of Oklahoma | 2019-05-31 | 2019-06-27 | |
| Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer Vaginal Cuff Brachytherapy, Short course vaginal cuff brachytherapy - Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma | Phase 3 | Recruiting | University of Utah | 188 | 2018-02-02 | 2025-12-12 |
| Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer Metformin Hydrochloride, Doxycycline - Breast Carcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 29 | 2016-06-08 | 2026-04-22 |
| Trial of Cisplatin Plus Radiation Followed by Carbo and Taxol Vs. Sandwich Therapy of Carbo and Taxol Followed Radiation Then Further Carbo and Taxol Cisplatin, Carboplatin, Paclitaxel - Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma | Phase 3 | Completed | Women's Cancer Care Associates, LLC | 48 | 2015-03-01 | 2024-07-23 |
| TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors Bevacizumab, Laboratory Biomarker Analysis, Pharmacological Study - Adult Glioblastoma, Endometrial Clear Cell Adenocarcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 50 | 2014-05-20 | 2026-08-28 |
| Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer Carboplatin, Laboratory Biomarker Analysis, Metformin Hydrochloride - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 / Phase 3 | Unknown | Gynecologic Oncology Group | 469 | 2014-03-17 | 2021-09-30 |
| Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancers Bevacizumab, Laboratory Biomarker Analysis, Nab-paclitaxel - Cervical Adenocarcinoma, Cervical Adenosarcoma | Phase 1 | Completed | Mayo Clinic | 43 | 2014-02-24 | 2024-07-26 |
| Dasatinib in Treating Patients With Recurrent or Persistent Ovarian, Fallopian Tube, Endometrial or Peritoneal Cancer Dasatinib, Laboratory Biomarker Analysis - Endometrial Clear Cell Adenocarcinoma, Ovarian Clear Cell Cystadenocarcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 35 | 2014-02-14 | 2023-08-01 |
| Trametinib With or Without GSK2141795 in Treating Patients With Recurrent or Persistent Endometrial Cancer Laboratory Biomarker Analysis, Trametinib, Uprosertib - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 26 | 2013-09-30 | 2020-10-14 |
| Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer Cabozantinib S-malate, Laboratory Biomarker Analysis, Pharmacological Study - Endometrial Adenosquamous Carcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 102 | 2013-05-08 | 2025-10-01 |
| PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients With High-Risk Endometrial Cancer Computed Tomography, Indocyanine Green Solution, Laboratory Biomarker Analysis - Endometrial Clear Cell Adenocarcinoma, Endometrial Mixed Adenocarcinoma | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 101 | 2013-04-03 | 2026-10-08 |
| Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer Dalantercept, Laboratory Biomarker Analysis - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 | Completed | Gynecologic Oncology Group | 28 | 2012-09-01 | 2018-03-13 |
| Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Nintedanib - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 | Completed | Gynecologic Oncology Group | 37 | 2011-10-01 | 2017-10-09 |
| Dasatinib, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer Carboplatin, Dasatinib, Laboratory Biomarker Analysis - Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 18 | 2011-09-20 | 2018-04-05 |
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Endometrial Neoplasms (6) · Carcinoma, Endometrioid (4) · Ovarian Neoplasms (4) · Fallopian Tube Neoplasms (3) · Carcinoma (2) · Carcinoma, Ovarian Epithelial (2) · Neoplasms (2) · Adenocarcinoma of Lung (1) · Breast Neoplasms (1) · Carcinosarcoma (1) · Fatigue (1) · Glioblastoma (1) · Krukenberg Tumor (1) · Mesothelioma, Malignant (1) · Mixed Tumor, Mesodermal (1)
Female Urogenital Diseases (12) · Female Urogenital Diseases and Pregnancy Complications (12) · Genital Diseases (12) · Genital Diseases, Female (12) · Genital Neoplasms, Female (12) · Neoplasms (12) · Neoplasms by Site (12) · Urogenital Diseases (12) · Urogenital Neoplasms (12) · Neoplasms by Histologic Type (9) · Uterine Neoplasms (9) · Adnexal Diseases (7) · Endocrine System Diseases (7) · Gonadal Disorders (7) · Uterine Diseases (7)
Paclitaxel (12) · Taxes (11) · Carboplatin (9) · Cisplatin (7) · Bevacizumab (5) · Disulfides (4) · Immunoglobulin G (4) · Radiation (4) · Radiotherapy (4) · Brachytherapy (3) · Doxorubicin (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Dasatinib (2) · Filgrastim (2) · Magnetic Resonance Spectroscopy (2)
National Cancer Institute (NCI) (13) · Gynecologic Oncology Group (12) · M.D. Anderson Cancer Center (2) · Elucida Oncology (1) · Mayo Clinic (1) · Multitude Therapeutics Inc. (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Oklahoma (1) · University of Utah (1) · Women's Cancer Care Associates, LLC (1)
United States (33) · Canada (5) · South Korea (4) · Puerto Rico (2) · Australia (1) · China (1) · Hong Kong (1) · Japan (1)
D. McMeekin (2) · Robert Coleman (2) · Akila Viswanathan (1) · Britt K Erickson (1) · Carol Aghajanian (1) · Catherine Shannon (1) · Cristina DeCesaris, MD (1) · Daniela E Matei (1) · David Bender (1) · David M Hyman (1) · David Tait (1) · Don Dizon (1) · Haider S Mahdi (1) · Howard Homesley (1) · Jeffrey Fowler (1)
PMID 25312396, PMID 25847373, PMID 25887099, PMID 30995174, PMID 31189035, PMID 31714586, PMID 31992589, PMID 33541735, PMID 34903380, PMID 35658479, PMID 36972022, PMID 37411031, PMID 38431043, PMID 39700442, PMID 40044930, PMID 40966692
U10CA027469 (17), U10CA180868 (16), P50CA098258 (3), P30CA006516 (2), U01CA062490 (2), UM1CA186709 (2), N01CM00032 (1), N01CM00038 (1), N01CM00071 (1), P30CA016672 (1), U01CA076576 (1), U10CA021661 (1), U10CA180830 (1), UM1CA186644 (1), UM1CA186712 (1)