9 completed. 5 Phase 3, 2 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 5 |
| Phase 2 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
Follow Edema, Cardiac: new trials by email Literature Review of Edema, Cardiac trials Research Report on Edema, Cardiac
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose-finding Study of JMKX003142 in Treatment of Cardiac Edema JMKX003142 Injection, JMKX003142 placebo - Cardiac Edema | Phase 2 | Completed | Jemincare | 160 | 2025-07-09 | 2026-08-06 |
| Lymphatic System Stimulation in Heart Failure The Optimal Lymph FLow (TOLF), Daily Monitoring - Heart Failure | Not applicable | Completed | Rutgers, The State University of New Jersey | 80 | 2023-08-15 | 2026-04-16 |
| A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF]) OPC 131461 10mg group, OPC 131461 5mg group, OPC 131461 2mg group - Cardiac Edema (CHF) | Phase 2 | Completed | Otsuka Pharmaceutical Co., Ltd. | 157 | 2023-01-10 | 2025-10-20 |
| Efficacy and Safety Study of Tolvaptan to Treat Patients With Cardiac Edema Tolvaptan, Placebo - Cardiac Edema | Phase 3 | Completed | Otsuka Beijing Research Institute | 244 | 2012-07-01 | 2013-12-30 |
| Efficacy and Safety of Tolvaptan in the Treatment of Cardiac-Induced Edema in Patients With Heart Failure Tolvaptan, Placebo - Cardiac-induced Edema | Phase 3 | Completed | Taiwan Otsuka Pharm. Co., Ltd | 85 | 2012-07-01 | 2015-06-02 |
| A Study of OPC-41061 in Subjects With Cardiac-induced Edema (Congestive Heart Failure) OPC-41061 （Tolvaptan) - Cardiac Edema | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 52 | 2007-10-01 | 2014-01-30 |
| A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure) OPC-41061(Tolvaptan), Placebo - Cardiac Edema | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 20 | 2007-09-01 | 2013-12-25 |
| A Double-blind, Placebo-controlled Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure) OPC-41061(Tolvaptan) - Edema, Cardiac | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 110 | 2007-04-01 | 2014-02-04 |
| Heart Failure and a Preserved Ejection Fraction O2 consumption max bike test - Heart Failure | Completed | Mayo Clinic | 51 | 2007-04-01 | 2010-10-14 |
Heart Failure (4) · Dyspnea, Paroxysmal (1) · Heart Failure, Diastolic (1)
Cardiovascular Diseases (9) · Edema (9) · Heart Diseases (9) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Heart Failure (5) · Dyspnea (1) · Respiration Disorders (1) · Respiratory Tract Diseases (1) · Signs and Symptoms, Respiratory (1)
Tolvaptan (5) · Population Groups (1)
Otsuka Pharmaceutical Co., Ltd. (4) · Jemincare (1) · Mayo Clinic (1) · Otsuka Beijing Research Institute (1) · Rutgers, The State University of New Jersey (1) · Taiwan Otsuka Pharm. Co., Ltd (1)
Japan (4) · China (2) · United States (2) · Taiwan (1)
Katsuhisa Saito (3) · Barry A. Borlaug, MD (1) · Chuen-Den Tseng (1) · Rida Gharzeddine, PhD (1) · Takeshi Tsunoda (1) · Zhang Jian (1)