4 recruiting, 2 terminated, 1 completed, 1 unknown. 5 Phase 1, 5 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Recruiting 2, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 5 | Recruiting 3, Terminated 1, Unknown 1 |
| Not applicable | 1 | Completed 1 |
Follow AML, Childhood: new trials by email Literature Review of AML, Childhood trials Research Report on AML, Childhood
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML Rabbit Anti thymocyte globulin, Busulfan, Fludarabine - AML, Childhood, Aml | Phase 1 / Phase 2 | Recruiting | Washington University School of Medicine | 68 | 2024-11-15 | 2026-08-24 |
| CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies Fludarabine, Cyclophosphamide, CD70-CAR T cell infusion (Autologous) - Hematologic Malignancy, ALL, Childhood | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 18 | 2024-10-16 | 2026-01-23 |
| ELU001 in Pediatric Subjects Who Have Relapsed and/or Refractory CBFA2T3-GLIS2-positive AML ELU001 - Acute Myeloid Leukemia, AML, Childhood | Phase 1 | Withdrawn | Elucida Oncology | 2024-06-07 | 2024-08-07 | |
| Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation Avapritinib, Azacitidine Injection, Decitabine Injection - AML, Childhood, Relapse/Recurrence | Phase 2 | Recruiting | Children's Hospital of Soochow University | 50 | 2024-03-01 | 2024-08-22 |
| Clinical Study of Induction Therapy Options Based on Molecular Subtyping and MRD in Children and Adolescents With AML Homoharringtonine, Cytarabine, Etoposide - AML, Childhood, Acute Myeloid Leukemia | Phase 2 | Recruiting | Children's Hospital of Soochow University | 500 | 2024-01-01 | 2024-08-22 |
| Retun-to-school Adaptation Program for Children With Cancer training and counselling, Interview - Childhood Cancer, ALL, Childhood | Not applicable | Completed | Gazi University | 20 | 2023-05-30 | 2025-09-29 |
| A Phase 1 Trial of CD33xCD3 BsAb in Pediatric Patients With Relapsed or Refractory Acute Myeloid Leukemia CD33*CD3 BsAb - AML, Childhood | Phase 1 | Terminated | Y-mAbs Therapeutics | 3 | 2022-05-25 | 2023-05-30 |
| AflacLL1901 (CHOA-AML) Cytarabine, Daunorubicin, Erwinase - Acute Myeloid Leukemia, AML, Childhood | Phase 2 | Terminated | Emory University | 8 | 2020-01-24 | 2022-06-15 |
| Nivolumab in Combination With 5-azacytidine in Childhood Relapsed/Refractory AML Nivolumab, 5-azacytidine - AML, Childhood | Phase 1 / Phase 2 | Unknown | Therapeutic Advances in Childhood Leukemia Consortium | 13 | 2019-11-29 | 2022-10-12 |
Leukemia, Myeloid, Acute (9) · Recurrence (3) · Lymphoma (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Hematologic Neoplasms (1) · Leukemia (1) · Neoplasms (1)
Hematologic Diseases (9) · Hemic and Lymphatic Diseases (9) · Leukemia, Myeloid (9) · Neoplasms by Histologic Type (9) · Leukemia (8) · Neoplasms (8) · Disease Attributes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Immune System Diseases (2) · Immunoproliferative Disorders (2) · Leukemia, Lymphoid (2) · Lymphatic Diseases (2) · Lymphoproliferative Disorders (2) · Neoplasms by Site (1)
Cytarabine (3) · Azacitidine (2) · Etoposide (2) · Granulocyte Colony-Stimulating Factor (2) · Idarubicin (2) · Sorafenib (2) · avapritinib (2) · fludarabine (2) · Antilymphocyte Serum (1) · Asparaginase (1) · Bone Marrow Transplantation (1) · Busulfan (1) · Counseling (1) · Cyclophosphamide (1) · Daunorubicin (1)
Children's Hospital of Soochow University (2) · Elucida Oncology (1) · Emory University (1) · Gazi University (1) · St. Jude Children's Research Hospital (1) · Therapeutic Advances in Childhood Leukemia Consortium (1) · Washington University School of Medicine (1) · Y-mAbs Therapeutics (1)
United States (5) · China (2) · Turkey (Türkiye) (1)
Shaoyan Hu, MD, PhD (2) · Gizem Cakir, PhD (1) · Himalee Sabnis, MD (1) · Jessica Pollard, MD (1) · Swati Naik, MBBS (1) · Thomas M Pfeiffer, M.D. (1)