30 completed. 30 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 30 | Completed 30 |
| Phase 2 | 6 | Completed 6 |
Follow Acute Lymphoblastic Leukemia: new trials by email Literature Review of Acute Lymphoblastic Leukemia trials Research Report on Acute Lymphoblastic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) IM JZP-458, IV JZP-458 - Acute Lymphoblastic Leukemia, Lymphoblastic Leukemia | Phase 2 / Phase 3 | Completed | Jazz Pharmaceuticals | 229 | 2019-12-27 | 2023-11-18 |
| Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) Blinatumomab, Dexamthasone - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Amgen | 121 | 2017-10-18 | 2023-02-08 |
| Phase III B in Acute Lymphoblastic Leukemia CTL019 - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Novartis Pharmaceuticals | 69 | 2017-04-24 | 2021-07-21 |
| Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Rituximab, Nelarabine, PEG-Asparaginase - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 3 | Completed | Goethe University | 1023 | 2016-08-01 | 2025-12-16 |
| A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase Apixaban, No systemic anticoagulant prophylaxis - Lymphoma, Acute Lymphoblastic Leukemia | Phase 3 | Completed | Bristol-Myers Squibb | 512 | 2015-10-22 | 2022-03-08 |
| Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies Radiation, Cyclophosphamide, Donor Lymphocyte Infusion (DLI) - Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | Phase 3 | Completed | Northwell Health | 10 | 2014-12-01 | 2022-04-07 |
| Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention tacrolimus, methotrexate, Mycophenolate mofetil - Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia | Phase 3 | Completed | Case Comprehensive Cancer Center | 101 | 2014-07-07 | 2023-09-11 |
| Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients Haplo-identical HSCT, Chemotherapy - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Peking University | 131 | 2014-07-01 | 2019-05-29 |
| P3 Study of Umbilical Cord Blood Cells Expanded With MPCs for Transplantation in Patients With Hematologic Malignancies Infusion of one MPC expanded cord unit and one unexpanded cord unit, Infusion of two unexpanded cord blood units. - Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia | Phase 3 | Completed | Mesoblast, Ltd. | 49 | 2013-08-01 | 2020-06-26 |
| A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia inotuzumab ozogamicin, FLAG (fludarabine, cytarabine and G-CSF), HIDAC (high dose cytarabine) - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Pfizer | 326 | 2012-08-02 | 2019-01-09 |
| Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Behavioral Intervention, Compliance Monitoring, Laboratory Biomarker Analysis - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Children's Oncology Group | 570 | 2012-02-21 | 2026-07-31 |
| Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia TBI+CY+VP-16, FA+TBI+CY+VP-16 - Acute Lymphoblastic Leukemia, Stem Cell Transplantation, Hematopoietic | Phase 2 / Phase 3 | Completed | Nanfang Hospital, Southern Medical University | 200 | 2011-10-01 | 2017-10-12 |
| Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Fludarabine Phosphate - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 3 | Completed | Fred Hutchinson Cancer Center | 174 | 2010-11-01 | 2026-04-30 |
| Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignancies Methotrexate, Pentostatin - Acute Lymphoblastic Leukemia, Acute Myelocytic Leukemia | Phase 3 | Completed | St. Jude Children's Research Hospital | 6 | 2010-09-01 | 2013-03-21 |
| Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Acute Lymphoblastic Leukemia, Adult B Lymphoblastic Lymphoma | Phase 3 | Completed | Children's Oncology Group | 9350 | 2010-08-11 | 2026-05-28 |
| ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy 6MPindividualized, 6MPfixed - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Copenhagen University Hospital, Rigshospitalet | 775 | 2009-01-01 | 2017-04-21 |
| ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase PEG Asparaginase at six weeks interval, PEG Asparaginase at two weeks interval - Acute Lymphoblastic Leukemia | Phase 3 | Completed | Copenhagen University Hospital, Rigshospitalet | 650 | 2009-01-01 | 2017-04-21 |
| Allogenic Bone Marrow Transplantation (BMT) Compare With Cytoreduction and Chemotherapy in Acute Lymphoblastic Leukemia (ALL) Patients Bone Marrow Transplantation, Chemotherapy - Acute Lymphoblastic Leukemia | Phase 2 / Phase 3 | Completed | Tehran University of Medical Sciences | 30 | 2008-10-01 | 2010-11-22 |
| Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic Leukaemia asparaginase, recombinant asparaginase - Acute Lymphoblastic Leukemia | Phase 3 | Completed | medac GmbH | 199 | 2008-10-01 | 2013-02-27 |
| Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Calaspargase Pegol-mknl, Cyclophosphamide, Cytarabine - Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia | Phase 3 | Completed | Children's Oncology Group | 166 | 2008-07-21 | 2021-04-27 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (30) · Leukemia, Myeloid, Acute (7) · Hodgkin Disease (5) · Myelodysplastic Syndromes (5) · Leukemia (4) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (4) · Lymphoma, Non-Hodgkin (3) · Multiple Myeloma (3) · Burkitt Lymphoma (2) · Leukemia, Biphenotypic, Acute (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Lymphoma (2) · Myeloproliferative Disorders (2) · Neoplasm, Residual (2) · Recurrence (2)
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Methotrexate (14) · Mercaptopurine (12) · Cytarabine (11) · Dexamethasone (11) · Cyclophosphamide (10) · Vincristine (10) · pegaspargase (10) · Doxorubicin (7) · azathiopurine (7) · merphos (7) · Calcium Dobesilate (6) · Daunorubicin (6) · Leucovorin (6) · Prednisone (6) · auricularum (6)
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Anne L Angiolillo (2) · Kjeld Schmiegelow, M.D. (2) · Sima Jeha, MD (2) · Ardeshir Ghavamzadeh, MD (1) · Asha Pillai, MD (1) · Betty Hamilton, MD (1) · Brenda Sandmaier (1) · Donna Skerrett, MD, MS (1) · Elizabeth J. Shpall, MD (1) · Eric C Larsen (1) · Joanne M Hilden (1) · Joel A Brochstein, MD (1) · Kelly W Maloney (1) · Lewis Silverman, MD (1)
PMID 39121442, PMID 37890117, PMID 24970932, PMID 26590194, PMID 29284596, PMID 38446568, PMID 40315406, PMID 23358966, PMID 23678006, PMID 24428625, PMID 25087182, PMID 25418987, PMID 25749825, PMID 26124497, PMID 26265699, PMID 26735993, PMID 27292104, PMID 27451978, PMID 28258828, PMID 28660740, PMID 28687420, PMID 29020310, PMID 29330398, PMID 29381191, PMID 29518185, PMID 29727043, PMID 29812996, PMID 30626253, PMID 30709437, PMID 30920645, PMID 30978155, PMID 31188727, PMID 31248843, PMID 31612640, PMID 31655984, PMID 31790983, PMID 32414392, PMID 32414848, PMID 32499241, PMID 32769965, PMID 32852553, PMID 33231879, PMID 33242441, PMID 33411585, PMID 33496745, PMID 33602684, PMID 34170389, PMID 35422096, PMID 35622074, PMID 35643855
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