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Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)

NCT03246269 — Completed, 334 participants, Andreas Monsch
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RegistryNCT03246269, acronym MoCA-Norm
StatusCompleted
Study typeObservational
Enrollment334 (Actual)
SponsorAndreas Monsch (Other)
ConditionsCognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom, Cognitive Change, Cognitive Deterioration, Cognitive Abnormality, Cognitive Impairment, Mild, Cognition Disorders in Old Age, Dementia, Dementia Alzheimers, Dementia, Alzheimer Type, Dementia, Mild, Dementia of Alzheimer Type
InterventionsMoCA (Diagnostic test)
Datesstart 2016-12-01, primary completion 2017-04-01, completion 2017-04-01, first posted 2017-08-11, last updated 2018-05-31

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-Summary

This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.

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+Detailed description

The Montreal Cognitive Assessment (MoCA) is a short tool to evaluate a multitude of cognitive domains (visuospatial / executive functioning, object naming, memory, attention, language, abstraction, orientation). The original English MoCA consistently showed very high sensitivity and specificity in distinguishing patients with mild cognitive impairment from healthy controls. Therefore it is an excellent tool for early recognition of cognitive disorders. Based on a Canadian sample, the MoCA proposes a cut-off-value of 26/30 points. However, there is increasing evidence of intercultural differences in terms of the best cut-off-score. In addition the original version only slightly corrects for possible influences of education - an adjustment for age- or gender-related effects is missing. Therefore, the aim of our study was to investigate the possible impacts of demographics on the MoCA total score and to provide normative values for a German-speaking population.

+Arms and interventions

ArmTypeInterventionsDescription
MoCA cohortDiagnostic Test: MoCAThe German MoCA is administered once to all study participants.
  • MoCA (Diagnostic test)

+Outcome measures

Primary outcomes

  • Montreal Cognitive Assessment (MoCA) - German version [Baseline]: Total score of the MoCA

Secondary outcomes

  • Mini-Mental State Examination (MMSE) [Baseline]: Total score of the MMSE
  • Geriatric Depression Scale (GDS) [Baseline]: Total score of the GDS
  • Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB) [Baseline]: Total score of the CERAD-NAB

+Eligibility

Sex: All, ages: 65 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Age ≥65 years
* Education ≥7 years
* Fluency in the German language
* Written informed consent

Exclusion Criteria:

* History of cognitive impairment
* Depression
* Severe sensory or motor impairment interfering with cognitive testing
* Serious somatic disease
* Disease or event affecting the central nervous system
* Cerebrovascular disease
* Regular medication with psychoactive drugs except for benzodiazepines
* Participation in a cognitive study within the last 3 months

+Investigators

My Notes