5 completed, 2 recruiting, 1 not yet recruiting, 1 suspended. 9 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 5, Recruiting 2, Not yet recruiting 1, Suspended 1 |
| Phase 1 | 3 | Completed 1, Not yet recruiting 1, Suspended 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PfSPZ-LARC2 Vaccine in Women of Child-bearing Potential (WOCBP) in Mali PfSPZ-LARC2 Vaccine, Normal Saline - Malaria (Plasmodium Falciparum) | Phase 2 | Recruiting | Sanaria Inc. | 300 | 2026-07-20 | 2026-07-23 |
| Field Trial of PfSPZ-LARC2 Vaccine in Burkinabe Adults Genetically attenuated PfSPZ Vaccine, Normal Saline (0.9% Sodium Chloride) - Malaria (Plasmodium Falciparum) | Phase 2 | Recruiting | Sanaria Inc. | 180 | 2026-05-04 | 2026-06-01 |
| Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults Pyronaridine Tetraphosphate, Artesunate Drug Combination, PfSPZ Challenge (NF54), MVA ME-TRAP - Malaria | Phase 1 / Phase 2 | Not yet recruiting | University Hospital Tuebingen | 30 | 2025-06-01 | 2024-12-06 |
| Controlled Human Malaria Infection Transmission Model - Phase A PfSPZ Challenge, Sulfadoxine-Pyrimethamine, Piperaquine - Malaria,Falciparum | Phase 1 / Phase 2 | Suspended | University of Oxford | 44 | 2022-08-22 | 2024-05-23 |
| Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria PfSPZ Vaccine, PfSPZ Challenge under chloroquine (CQ) chemoprophylaxis, Normal Saline - Malaria | Phase 2 | Completed | Sanaria Inc. | 345 | 2022-05-07 | 2026-05-04 |
| PfSPZ Vaccine Trial in Malian Children Sanaria® PfSPZ Vaccine, Normal Saline - Malaria, Malaria,Falciparum | Phase 2 | Completed | Sanaria Inc. | 290 | 2022-04-01 | 2024-02-07 |
| Safety, Tolerability and Protective Efficacy of PfSPZ Vaccine in Gabonese Children PfSPZ Vaccine, Normal Saline - Malaria | Phase 2 | Completed | Sanaria Inc. | 200 | 2018-06-14 | 2021-10-07 |
| Safety, Tolerability and Efficacy of PfSPZ Vaccine in Healthy Children and Infants 5 Months - 9 Years Living in Kenya PfSPZ Vaccine, Normal Saline - Malaria | Phase 1 / Phase 2 | Completed | Sanaria Inc. | 337 | 2016-07-21 | 2019-04-19 |
| PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults PfSPZ Vaccine, CHMI (7G8), CHMI (NF135.C10) - Malaria | Phase 2 | Completed | Sanaria Inc. | 92 | 2016-01-01 | 2018-10-16 |
Malaria (8) · Malaria, Falciparum (8)
Saline Solution (6) · Sodium Chloride (2) · 1-acetyl-1,2,3,3a,8,8a-hexahydro-8a-hydroxy-5-methoxypyrrolo(2,3-b)indole (1) · Artemether, Lumefantrine Drug Combination (1) · Chemoprevention (1) · Primaquine (1) · fanasil, pyrimethamine drug combination (1) · piperaquine (1) · pyronaridine tetraphosphate, artesunate drug combination (1)
Kenya (2) · Mali (2) · Burkina Faso (1) · Gabon (1) · Indonesia (1) · United States (1)
Alassane Dicko, MD PhD (1) · Alexandra Singer, MD (1) · Erni J Nelwan, MD, Ph.D. (1) · Issaka Sagara, MD MSPH PhD (1) · Kevin Baird, Ph.D. (1) · Martina Oneko, MD (1) · Patrick Duffy, MD (1) · Selidji Agnandji, MD (1) · Sodiomon B Sirima, MD PhD (1)
PMID 31555824, PMID 32444192, PMID 32920641, PMID 34518679, PMID 40972633