4 completed, 2 terminated. 6 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Terminated 2 |
| Phase 1 | 4 | Completed 2, Terminated 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability and Efficacy of Uproleselan (GMI-1271) in Patients With COVID-19 Pneumonia Uproleselan - COVID-19 Pneumonia | Phase 1 / Phase 2 | Terminated | Lena Napolitano, MD | 6 | 2021-11-12 | 2023-07-10 |
| Uproleselan (GMI-1271) for GI Toxicity Prophylaxis During Melphalan-Conditioned Autologous Hematopoietic Cell Transplantation (Auto-HCT) for Multiple Myeloma (MM) Uproleselan, Placebo, Melphalan - Multiple Myeloma | Phase 2 | Completed | Washington University School of Medicine | 51 | 2021-05-05 | 2023-12-15 |
| Study to Assess Safety, Tolerability, and Efficacy of GMI-1271 in Patients With Calf-level Deep Venous Thrombosis (DVT) GMI-1271, Enoxaparin Sodium (Lovenox®) - Deep Venous Thrombosis | Phase 1 / Phase 2 | Terminated | GlycoMimetics Incorporated | 2 | 2016-07-01 | 2019-06-14 |
| Study to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in AML GMI-1271, Mitoxantrone, Etoposide - Leukemia, Myeloid, Acute | Phase 1 / Phase 2 | Completed | GlycoMimetics Incorporated | 91 | 2015-03-01 | 2019-05-17 |
| Study of GMI-1070 for the Treatment of Sickle Cell Pain Crisis GMI-1070, Placebo - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 2 | Completed | GlycoMimetics Incorporated | 81 | 2010-05-01 | 2020-05-13 |
| Study of Intravenous GMI-1070 in Adults With Sickle Cell Disease GMI-1070 - Sickle Cell Disease | Phase 1 / Phase 2 | Completed | GlycoMimetics Incorporated | 15 | 2009-05-01 | 2020-05-11 |
Anemia, Sickle Cell (2) · Leukemia, Myeloid, Acute (1) · Multiple Myeloma (1) · Vaso-Occlusive Crises (1) · Venous Thrombosis (1)
uproleselan (4) · rivipansel (2) · Cytarabine (1) · Enoxaparin (1) · Etoposide (1) · Idarubicin (1) · Melphalan (1) · Mitoxantrone (1) · enoxaparin sodium (1)
United States (6) · Australia (1) · Canada (1) · Ireland (1)
Helen Thackray, MD (2) · Daniel DeAngelo, MD, PhD (1) · Keith Stockerl-Goldstein, M.D. (1) · Lena Napolitano, MD (1) · Marilyn J Telen, MD (1) · Suman Sood, MD (1)
PMID 22129980, PMID 24988449, PMID 25733584, PMID 34543383, PMID 35120836