3 recruiting, 2 completed. 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 2 | Recruiting 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Single and Multiple Ascending Dose Study of EPX-100 in Healthy Adult Participants EPX-100, EPX-100-Matching Placebo, Moxifloxacin - Healthy Participants | Phase 1 | Recruiting | Epygenix | 88 | 2026-08-05 | 2026-10-16 |
| An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome Clemizole HCl, Placebo - Lennox Gastaut Syndrome | Phase 3 | Recruiting | Epygenix | 260 | 2025-04-09 | 2026-10-09 |
| Drug-drug Interaction Study of Clemizole (EPX-100) in Healthy Participants EPX-100, Itraconazole, Phenytoin - Drug Drug Interaction | Phase 1 | Completed | Epygenix | 54 | 2025-01-15 | 2026-09-17 |
| A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome Clemizole HCl, Placebo - Dravet Syndrome | Phase 3 | Recruiting | Epygenix | 150 | 2020-09-15 | 2026-10-29 |
| Study of Safety and Pharmacokinetics of Oral Doses of EPX-100 in Healthy Subjects. EPX-100 (Clemizole Hydrochloride), Placebos - Dravet Syndrome | Phase 1 | Completed | Epygenix | 24 | 2019-08-29 | 2024-09-19 |
Epilepsies, Myoclonic (2) · Seizures (2) · Lennox Gastaut Syndrome (1)
Bupropion (1) · Itraconazole (1) · Midazolam (1) · Moxifloxacin (1) · Omeprazole (1) · Phenytoin (1) · clemizole (1)
United States (5) · China (2) · Hungary (2) · India (2) · Poland (2) · Spain (2) · Argentina (1) · Brazil (1) · Canada (1) · Georgia (1) · Italy (1) · Romania (1) · Serbia (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Amit Ray, MD (2) · Amit Ray, MD, MBA, FAES, FAAN (1) · Hahn-Jun Lee, Ph.D. (1) · Robert Faulkner, PhD (1)