6 completed. 2 Early Phase 1, 2 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 2 | Completed 2 |
| Not applicable | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Effects of Ultra-processed Versus Unprocessed Foods on Glucocorticoid Secretion in Healthy Individuals Ultra-processed breakfast, Low-processed breakfast - Glucocorticoids, Obesity and Overweight | Not applicable | Completed | Eleonora Seelig | 20 | 2024-10-30 | 2026-03-03 |
| Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake Metyrapone And Hydrocortisone, Placebo - Glucocorticoids, Overweight and Obesity | Not applicable | Completed | Eleonora Seelig | 23 | 2024-09-01 | 2026-05-22 |
| The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve) Metyrapone 250 mg Oral Tablets, Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s, Placebo 250 mg Tablets - Glucocorticoid Effect | Early Phase 1 | Completed | Eleonora Seelig | 24 | 2023-05-15 | 2024-08-14 |
| Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals Metyrapone 250 mg Oral Tablets, Placebo 250 mg Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s - Glucocorticoid Effect | Early Phase 1 | Completed | Eleonora Seelig | 20 | 2022-02-08 | 2023-08-23 |
| Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin Metformin 500 mg Oral Tablets + Prednisone 20mg Tablets, Placebo 500 mg Tablets + Prednisone 20mg Tablets - Glucocorticoid Effect | Phase 4 | Completed | Eleonora Seelig | 19 | 2021-02-25 | 2021-09-23 |
| Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects High-calorie meal - Overweight and Obesity | Completed | Eleonora Seelig | 36 | 2020-05-14 | 2022-03-23 |
Obesity (3) · Overweight (3) · Fasting (1) · Hyperphagia (1) · Insulin Resistance (1) · Starvation (1)
Metyrapone (3) · Hydrocortisone (2) · Metformin (1) · Prednisone (1)
Switzerland (6)
PMID 18253159, PMID 18349741, PMID 19299006, PMID 25390020, PMID 25815990, PMID 28554927, PMID 28604169