54 completed, 8 terminated, 7 unknown, 4 recruiting. 33 Phase 2, 28 Not applicable, 14 Phase 3, 9 Phase 1, 7 Phase 4.
Follow Vitamin B12: new trials by email Literature Review of Vitamin B12 trials Research Report on Vitamin B12
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin B12 Absorption Study Ampli-B, Vitamin B12 - Healthy Volunteers | Phase 4 | Completed | RDC Clinical Pty Ltd | 12 | 2026-07-20 | 2026-09-09 |
| Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance Vitamin B 12, Natural orange extract, Vitamina B12 + natural orange extract - Vitamin b12, Supplementation During Endurance Performance | Not applicable | Enrolling by invitation | Francisco Javier MartÃnez Noguera | 20 | 2025-12-01 | 2026-01-14 |
| ICOPE INTENSE-K Pilot Study ICOPE intense intervention, Ketone Ester (KE) supplementation, Placebo - Ageing | Not applicable | Recruiting | University Hospital, Toulouse | 40 | 2025-07-09 | 2025-07-23 |
| Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA Vitamin B12 - Sickle Cells Patients | Recruiting | CHU de Reims | 29 | 2024-11-27 | 2025-12-10 | |
| THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMES Vitamin B12 - Premature Ejaculation | Completed | OZGUR EKICI | 54 | 2024-10-01 | 2025-06-25 | |
| Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease Folic Acid 1 MG, Vitamin B6 25 MG, Vitamin B12 - Parkinson&Amp;#39;s Disease | Not applicable | Recruiting | Oregon Health and Science University | 150 | 2024-03-05 | 2025-01-13 |
| Relationship Between Vitamins and Radiologic Stage in Knee Osteoarthritis Direct digital radiography, 25-OH Vitamin D, Vitamin B12 - Knee Osteoarthritis | Completed | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 104 | 2023-12-01 | 2024-02-20 | |
| Combination Therapy of Different Antidepressants With Dietary Supplements L-methylfolate, Vitamin B12, magnesium - Depression | Not applicable | Completed | Riphah International University | 88 | 2022-10-05 | 2023-09-11 |
| Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy Pregabalin 150mg gabapentin 400mg - Opioid Use | Phase 3 | Unknown | Research Institute of Ophthalmology, Egypt | 72 | 2022-09-15 | 2022-10-27 |
| Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) Cobalamin, Dexamethasone, Docetaxel - Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma | Phase 2 / Phase 3 | Active not recruiting | SWOG Cancer Research Network | 82 | 2022-03-15 | 2026-05-18 |
| Intrathecal Pemetrexed for Leptomeningeal Metastasis Pemetrexed (1), Pemetrexed (2), Folic Acid - Leptomeningeal Metastases | Phase 1 / Phase 2 | Completed | The First Hospital of Jilin University | 34 | 2022-02-21 | 2025-05-04 |
| Early Infant Micronutrition and Development Cyanocobalamin - Vitamin B 12 Deficiency | Phase 2 / Phase 3 | Recruiting | Sykehuset Innlandet HF | 600 | 2021-12-08 | 2023-04-18 |
| Vitamin B12 for Aromatase Inhibitors Associated Musculoskeletal Symptoms in Breast Cancer Vitamin B12, Blood collection, Brief Pain Inventory - Short Form survey - HR-positive Breast Cancer | Not applicable | Withdrawn | Case Comprehensive Cancer Center | 2021-08-12 | 2024-08-21 | |
| Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury Vitamin B3, Vitamin B12 - Traumatic Brain Injury | Phase 3 | Completed | KRL Hospital, Islamabad | 300 | 2021-06-01 | 2023-07-24 |
| International ALLIANCE Study of Therapies to Prevent Progression of COVID-19 Vitamin C, Hydroxychloroquine, Azithromycin - COVID19 | Phase 2 | Unknown | National Institute of Integrative Medicine, Australia | 200 | 2020-09-09 | 2020-09-11 |
| GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response Cyanocobalamin, Dulaglutide - Glucose Intolerance, Overweight and Obesity | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 23 | 2020-05-15 | 2024-12-05 |
| Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics Pyridoxine, Cobalamin, Placebo Oral Tablet - Schizophrenia, Drug Induced Movement Disorder, Unspecified | Phase 2 / Phase 3 | Unknown | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara | 45 | 2019-09-03 | 2019-12-18 |
| Vitamin B12 for Carpal Tunnel Syndrome Vitamin B12, Normal saline - Carpal Tunnel Syndrome | Not applicable | Withdrawn | Tri-Service General Hospital (TSGH) | 2019-04-20 | 2020-10-08 | |
| Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients methylcobalamin, Folic Acid, Placebo for methylcobalamin - Post Operative Cognitive Dysfunction | Not applicable | Terminated | Xijing Hospital | 40 | 2019-01-10 | 2021-08-04 |
| Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients Injection Mecobalamin, Tablet Pyridoxine hydrochlorid, Normal saline - Vincristine Induced Neurotoxicity, Acute Lymphoblastic Leukaemia | Phase 2 / Phase 3 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 40 | 2018-03-29 | 2020-07-08 |
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Vitamin B 12 Deficiency (10) · Carcinoma, Non-Small-Cell Lung (6) · Recurrence (6) · Lung Neoplasms (5) · Breast Neoplasms (3) · Lymphoma, T-Cell, Peripheral (3) · Neoplasm Metastasis (3) · Anemia (2) · Autistic Disorder (2) · Cardiovascular Diseases (2) · Diabetes Mellitus, Type 2 (2) · Hyperhomocysteinemia (2) · Lymphoma (2) · Lymphoma, B-Cell (2) · Lymphoma, T-Cell (2)
Acrotech Biopharma Inc. (6) · Eli Lilly and Company (3) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (2) · Centre For International Health (2) · Chinese University of Hong Kong (2) · Harvard School of Public Health (HSPH) (2) · Haukeland University Hospital (2) · National Institute on Aging (NIA) (2) · Spectrum Pharmaceuticals, Inc (2) · The First Hospital of Jilin University (2) · University of Aarhus (2) · Xijing Hospital (2) · AHS Cancer Control Alberta (1) · Aga Khan University (1) · Ali Altunkaya (1)
United States (28) · China (6) · France (6) · India (5) · Bangladesh (4) · Italy (4) · Norway (4) · Spain (4) · Australia (3) · Brazil (3) · Pakistan (3) · United Kingdom (3) · Argentina (2) · Belgium (2) · Canada (2)
Garry Weems, PharmD (2) · Michael Saunders, MD (2) · Per Magne Ueland, M.D., Ph.D. (2) · Tor A Strand, MD/PhD (2) · Zeina Nahleh, MD (2) · Absalon D Gutierrez, MD (1) · Afifa Siddique, MBBS (1) · Alexandros Kanellopoulos (1) · Amalia A Tsiami, PhD (1) · Amelie Lansiaux, MD, PhD (1) · Andrea Baccarelli, MD PHD MPH (1) · Anne-Mette Hvas, MD, PhD (1) · Anura Kurpad, MBBS, PhD (1)
PMID 24025626, PMID 29472265, PMID 1447744, PMID 15117425, PMID 16531614, PMID 17315026, PMID 18809959, PMID 18854539, PMID 19056591, PMID 19118243, PMID 19605506, PMID 19901100, PMID 21623649, PMID 22002941, PMID 22915298, PMID 23440491, PMID 23566267, PMID 23726971, PMID 23902779, PMID 24598885, PMID 24991768, PMID 25802345, PMID 26098427, PMID 26123683, PMID 26889605, PMID 27243238, PMID 27486122, PMID 27823800, PMID 28289216, PMID 28367952, PMID 28431557, PMID 28771889, PMID 28851784, PMID 28923060, PMID 29038891, PMID 30187524, PMID 30339737, PMID 30782904, PMID 31005968, PMID 31367538, PMID 31544065, PMID 31640736, PMID 32019814, PMID 32041632, PMID 32470975, PMID 33180098, PMID 33259482, PMID 34661903, PMID 34999324, PMID 35526057
2008 (1), M01RR000082 (1), P42ES010349 (1), R01AG017160 (1), R21AT002571 (1), R21CA107277 (1), R21DK122234 (1), U10CA180888 (1)